Long-Term Outcomes after Repeat Doses of Antenatal Corticosteroids

Abstract

Children who had been exposed to repeat as compared with single courses of antenatal corticosteroids did not differ significantly in physical or neurocognitive measures. Although the difference was not statistically significant, the higher rate of cerebral palsy among children who had been exposed to repeat doses of corticosteroids is of concern and warrants further study. (ClinicalTrials.gov number, NCT00015002 [ClinicalTrials.gov].).

Caveolin-1 Regulates Genomic Action of the Glucocorticoid Receptor in Neural Stem Cells

“…Although the use of synthetic prenatal GCs to promote lung maturation in preterm infants is undisputed, clinical and preclinical studies have revealed the potential for prolonged or delayed side effects linked to antenatal or neonatal GC usage (5)(6)(7). In several species, including humans, these studies indicate that exogenous treatment with GCs during fetal or neonatal development or fetal exposure to high levels of endogenous GCs produced as a result of maternal stress can be associated with neurological, cognitive, and affective disorders that emerge later in childhood (7,8).…”

Premature Birth and Disease Programming. Contribution of Neonatal Intensive Care

“…С одной стороны, их применение в раннем неонатальном периоде уменьшает длительность искусственной вентиляции [51], с другой -сопряжено с увеличением концентрации глюкозы в кро-ви, замедлением набора веса и увеличением частоты таких клинических осложнений, как некротизирующий энтероколит [52]. Введение дексаметазона новорожден-ным крысам приводило к гипоплазии легких и легочной гипертензии [52].…”

Múltiples cursos de corticoides antenatales para el parto prematuro (MACS): un estudio randomizado controlado

“…Por este motivo se sugirió como una buena práctica clínica, la repetición semanal de cursos de corticoides a las mujeres que luego de un primer curso de corticoides, permanecen en riesgo de parto prematuro. Las investigaciones de diseño retrospectivo pusieron en duda la seguridad y eficacia de esta práctica (4,5), y los estudios prospectivos randomizados hasta ahora publicados no permiten una conclusión definitiva (6). Es indispensable contar con estudios de diseño prospectivo que permitan responder si el uso de dosis repetidas de corticoides en mujeres en riesgo de parto prematuro, resultan en más beneficio que daño, o viceversa.…”