Long-term outcome of smear-positive tuberculosis patients after initiation and completion of treatment: A ten-year retrospective cohort study

Dangisso, Mesay Hailu; Woldesemayat, Endrias Markos; Datiko, Daniel Gemechu; Lindtjørn, Bernt

doi:10.1371/journal.pone.0193396

Cited by 14 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dangisso et al revealed that people over the age of 34 were twice as likely to die from TB. [28] These results are similar to those of our study, in which the median age was 34 years. This may be due to the increase of comorbidities with age as it was reported in that Ethiopian study.…”

Section: Discussionsupporting

confidence: 91%

Incidence and predictors of death among adult patients treated for tuberculosis in two regions of Cameroon: 2010 to 2015

Balkissou

Pefura-Yone

Poka³

et al. 2022

JPATS

View full text Add to dashboard Cite

Objectives: Mortality during tuberculosis (TB) remains high in Africa. The purpose of our study was to determine the incidence and predictors of death during TB treatment in Cameroon. Materials and Methods: Data of subjects aged ≥15 years were retrospectively extracted from registers in all TB diagnostic and treatment centers in the Western and Northern regions of Cameroon from 2010 to 2015. Cox regression models were used to determine predictors of death during TB treatment. Results: Of the 19,681 patients included, 12,541 (63.7%) were male and their median age (25th-75th percentile) was 34 (26–45) years. The cumulative incidence (95% confidence interval [CI]) of death during TB treatment was 8.0% (7.5–8.5%). The predictors (hazard ratios [95% CI]) of death were: Age >34 years (1.479 [1.295–1.688], P < 0.001), female sex (1.471 [1.286–1.683], P < 0.001), extra-pulmonary TB (1.723 [1.466–2.026], P < 0.001), human immunodeficiency virus infection (3.739 [3.269–4.276], P < 001]), TB treatment in the Western region (2.241 [1.815–2.768], P < 0.001), treatment before 2012 (1.215 [1.073–1.376], P = 0.002)and low body weight (1st quartile and 2nd quartile) (2.568 [2.133–3.092], [P < 0.001]) and (1.569 [1.298–1.896], P < 0.001) respectively. Conclusion: The incidence of death during TB was relatively high in the Western and Northern regions of Cameroon. Recognition of these persons at greatest risk may improve care and reduce death durinng TB treatment.

show abstract

Section: Discussionsupporting

confidence: 91%

Incidence and predictors of death among adult patients treated for tuberculosis in two regions of Cameroon: 2010 to 2015

Balkissou

Pefura-Yone

Poka³

et al. 2022

JPATS

View full text Add to dashboard Cite

show abstract

“…In this setting, presumptive TB cases were continuously identified and screened through a house-to-house visit for two years prior to the survey by innovative community based approach by TB REACH project [ 19 ]. The low prevalence reported from this district could be a proxy to declining in prevalence or lower TB incidence due to the intervention and long term implementation of DOTS [ 19 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Sub-national prevalence survey of tuberculosis in rural communities of Ethiopia

et al. 2019

View full text Add to dashboard Cite

BackgroundTuberculosis is a major public health problem with varying prevalence in different settings. National prevalence surveys provide evidence for planning and decision making. However, they lack the capacity to estimate subnational magnitude that affected the capacity to make selected intervention based on the prevalence. Ethiopia is among high TB burden countries with estimated prevalence of 108 per 100,000 population varying by regions. We aimed to study sub national prevalence of smear-positive TB in rural communities of southern Ethiopia.MethodsThis cross-sectional study, enrolled community members aged over 14 years who had cough of at least two weeks duration. Two sputum samples were collected and examined by using smear microscopy.Results38,304 eligible people were enumerated (10,779 from Hadiya, 10,059 from Gurage and 17,466 from Sidama) and indentified 960 presumptive cases. 16, 14 and 14 smear-positive pulmonary TB cases were identified respectively. The point prevalence of smear-positive TB were 148 per 100,000 population (95% CI: 91–241) in Hadiya, 139 per 100,000 population (95% CI: 83–234) in Gurage and 80/100,000 population (95%CI: 48–135) in Sidama zone. Gurage zone had the highest prevalent to notified cases of seven to one.ConclusionsThe prevalence of smear positive TB varies by districts and is high in rural southern Ethiopia compared to the estimated national prevalence. More TB patients remain missed and unreached, impacting negatively on health outcomes. TB case finding approaches should be revisited and innovative approaches and tools to identify missing people with TB should be scaled up.

show abstract

“…In a ten-year retrospective cohort study, consisting of 2730 smear-positive TB cases, 458 (16%) eligible TB cases were missed from a survey due to migration to other areas. 27 Some of these cases might have migrated to low TB incidence areas or to receiving countries which may have their TB epidemiology affected. Various studies reported that people with history of TB treatment may have recurrent TB.…”

Section: Migration and Tbmentioning

confidence: 99%

“…Various studies reported that people with history of TB treatment may have recurrent TB. 27 , 28 Generally, the incidence of TB is low in high-income countries, however, it is high among specific groups of people such as migrant populations. Migrants in low TB incidence countries may come from high TB burden areas, where they have contracted mycobacterium tuberculosis infections.…”

Section: Migration and Tbmentioning

confidence: 99%

Tuberculosis in Migrants is Among the Challenges of Tuberculosis Control in High-Income Countries

Woldesemayat¹

2021

RMHP

Self Cite

View full text Add to dashboard Cite

The incidence of tuberculosis (TB) is high among migrants in high-income countries. The migration process could contribute to the high incidence of TB among them. Achieving TB elimination from these settings will be difficult unless countries address the burden of TB among migrants. The aim of this review was to describe the challenges of international migration on TB control in high-income, low TB incidence countries. Among migrants, there is a high prevalence of risk factors for TB, such as exposure to TB, HIV, malnutrition, substance use, delayed diagnosis, low education, poor health-seeking, the culture, stigma and marginalization. Discriminatory policies of TB care and social barriers such as language, cultural issues and unfriendly health services may also contribute to the high prevalence of TB among them. TB control among migrants in these settings is important as migrants are vulnerable to TB infection and disease, and implementing TB care among them is difficult; it is important to reduce the TB burden in migrants and the community at large and the high risk of multidrug-resistant TB (MDR-TB). TB elimination from high-income countries requires acquiring data and analyzing it to measure the burden, having migrant-sensitive health systems, having policy and legal frameworks and multicountry partnerships and conducting research.

show abstract

Long-term outcome of smear-positive tuberculosis patients after initiation and completion of treatment: A ten-year retrospective cohort study

Cited by 14 publications

References 25 publications

Incidence and predictors of death among adult patients treated for tuberculosis in two regions of Cameroon: 2010 to 2015

Incidence and predictors of death among adult patients treated for tuberculosis in two regions of Cameroon: 2010 to 2015

Sub-national prevalence survey of tuberculosis in rural communities of Ethiopia

Tuberculosis in Migrants is Among the Challenges of Tuberculosis Control in High-Income Countries

Contact Info

Product

Resources

About