Long-term outcome of single pediatric donor kidney transplants between African-American and non-African-American adults

Paramesh, Anil; Zhang, R; Cl, Yau; Balamuthusamy, Saravanan; Shenava, Rajesh; Killackey, Mary; Alper, Brent; Simon, Eric E.; Slakey, Douglas P.; Florman, Sandy

doi:10.5414/cnp72055

Cited by 3 publications

(4 citation statements)

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“…Despite a higher incidence of proteinuria in the pediatric-graft recipients, the 1-year survival was similar in the two groups and serum creatinine levels were not different at 1 and 3 years. Paramesh et al [13] found similar outcomes in African American and non-African American adult recipients of single PDK kidneys. Balamuthusamy et al [12] described that obesity was not a negative prognostic factor.…”

Section: Discussionmentioning

confidence: 60%

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Glomerulopathy in Adult Recipients of Pediatric Kidneys

Choung

Meleg-Smith

2014

Ultrastructural Pathology

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To compare "for cause" renal biopsies (bx) from adult recipients of pediatric-donor kidneys (PDK) versus adult-donor kidneys (ADKs), we reviewed 103 graft bx from 50 PDK recipients and 85 bx from 49 ADK recipients. PDK bx displayed more frequent glomerular pathology with immune complex-mediated glomerulonephritis present in 11/103 PDK versus 1/85 ADK (p < 0.05). In 15/103 PDK bx and 1/85 ADK (p = 0.001), the association of glomerular sclerosis, expanded mesangium, and halo of prominent podocytes by light microscopy, and ultrastructural glomerular basement membrane lamellation, configured a characteristic glomerulopathy.

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Section: Discussionmentioning

confidence: 60%

“…Clinical findings and outcome of these 99 patients have been described in detail in several publications [11][12][13][14]. Conversely, the present study is a thorough review of the renal biopsies, to investigate findings in adult recipients of PDK grafts, and compare the pathology with bx of ADK grafts.…”

Section: Patient Datamentioning

confidence: 95%

Glomerulopathy in Adult Recipients of Pediatric Kidneys

Choung

Meleg-Smith

2014

Ultrastructural Pathology

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“…A recent analysis based on United States Renal Data System from 2000 to 2005 indicated that both patient and graft survival were similar in AA and Caucasian patients using either thymoglobulin or IL‐2 receptor antibody induction [24]. As reported previously, our center’s experience suggested that T‐cell depleting antibody induction might no longer be necessary in the era of potent maintenance of tacrolimus, mycophenolate acid and steroids [25,26]. Non‐T‐cell depleting antibody basiliximab induction was used for our high‐risk patients, including in this study.…”

Section: Discussionmentioning

confidence: 63%

Long-term outcome of highly sensitized African American patients transplanted with deceased donor kidneys

Ren¹,

Paramesh²,

Yau³

et al. 2010

Transplant International

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Summary Undertaking transplantation in highly sensitized African American (AA) patients as transplant recipients represents a unique challenge. We retrospectively compared the outcomes of AA with non‐African American (NAA) patients who had panel reactive antibody >80% and received deceased donor (DD) kidneys by virtual crossmatch. Immunosuppressive regimen included basiliximab induction and tacrolimus, mycophenolate acid and steroids maintenance. Among 835 consecutive transplants from 1998 to 2007, 142 (17%) were sensitized patients including 89 (16.6%) AA and 53 (17.7%) NAA patients. The AA group had similar 5‐year incidence of acute rejection as NAA group (21.4% vs. 26.4%, P = 0.25). Kaplan–Meier estimated graft survival at 1, 3 and 5 years were 91%, 85% and 82% in AA group, and 94%, 79% and 71% in NAA group (P = 0.08). The death‐censored graft survival at 1, 3, and 5 years were 93%, 86% and 84% in AA group, and 96%, 83% and 78% in NAA group (P = 0.11). The 1, 3, and 5 years patient survivals were 93%, 88% and 85% in AA group, and 96%, 96% and 94% in NAA group (P = 0.17). Highly sensitized AA patients could be transplanted with DD kidneys at a similar rate as NAA patients, and they may not have a higher incidence of rejection or an inferior graft survival than NAA patients.

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“…The estimated graft survival has slowly improved over time and the most recent data, from the 1998–1999 cohort, is estimated at 11.6 years, according to national statistics. Grafts from living donors have a higher estimated life, at 15 years 27,33…”

Section: Solid Organ Transplantationmentioning

confidence: 99%