Long-term outcome of radical cystectomy in ESDR patients with bladder urothelial carcinoma

Abstract

Dialysis patients in a stable chronic dialysis condition with recurrent or invasive bladder urothelial carcinoma could have survival benefits in receiving concurrent nephroureterectomy.

Shorter hemodialysis duration is a risk factor for the recurrence of urothelial carcinoma of the bladder in patients on maintenance hemodialysis

“…In Asia, UC of the bladder (UCB) is the major cancer affecting MHD patients [8,16]. In the present study, for the first time, we showed that shorter HDD is an independent risk factor for the occurrence and recurrence of UCB, although the SIR of bladder cancer in maintenance hemodialysis patients has been reported to be higher than that of their healthy counterparts [7].…”

“…ESRD has been reported to be associated with an increased incidence of malignancy, particularly urological cancer [2,9,10,[14][15][16]. In Asia, UC of the bladder (UCB) is the major cancer affecting MHD patients [8,16].…”

“…In particular, Chen et al reported a high frequency of UC in uremic patients [17]. Several hypotheses are proposed to explain this finding, including impaired DNA repair ability, immune defects, nutritional deficiencies, and chronic urinary tract infection [2,8,16]. Wu et al evaluated 73 patients with upper urinary tract urothelial carcinoma (UUT-UC) on dialysis therapy and identified a high recurrence rate in these patients [12].…”

“…Patients with UC on hemodialysis had a higher recurrence rate in the urinary tract than patients not on hemodialysis. Wu et al reported that the final bilateral nephroureterectomy rate was 56.7 % and one-step bilateral nephroureterectomy and radical cystectomy are a recommended treatment for patients with UC on hemodialysis [3,16]. However, a recent study showed no statistical difference for overall survival between one-step and two-step bilateral nephroureterectomy.…”

Metachronous urothelial carcinoma of whole urinary tract in a dialysis-dependent patient: A case report

“…A recent study of dialysis patients with UC reported that the 5-year survival rate of patients undergoing radical cystectomy with concurrent nephroureterectomy was better compared with that of patients who did not undergo concurrent nephroureterectomy. The authors suggest aggressive treatment in patients in a chronic stable condition to improve survival rate ( 9 ). However, a high mortality rate was noted in patients undergoing cystectomy with concurrent nephroureterectomy due to various complications ( 9 , 10 ).…”