Long-Term Outcome of Pediatric Obsessive-Compulsive Disorder: A Meta-Analysis

Liu, Jingran; Cui, Yonghua; Yu, Liping; Wen, Fang; Wang, Fang; Yan, Junjuan; Yan, Cao; Li, Ying

doi:10.1089/cap.2020.0051

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…ODD irritability dimension is most often comorbid with anxiety (Martín et al, 2014) and depressive disorders (Burke & Loeber, 2010), and the defiant dimension with attention-deficit/hyperactivity disorder (ADHD) (Harvey et al, 2016) and conduct disorder (Nock et al, 2006). In the case of OCD, in about half of cases the disorder starts in childhood, with prevalence until adolescence ranging from 0.1 to 4% (Heyman et al, 2001), and persistence rates of 40% (Liu et al, 2021). About 80% of children with OCD meet diagnostic criteria for other psychological disorders (Langley et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Irritability, Defiant and Obsessive-Compulsive Problems Development from Childhood to Adolescence

Ezpeleta

Penelo

Navarro

et al. 2021

J Youth Adolescence

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Little is known about the coexistence of oppositionality and obsessive-compulsive problems (OCP) in community children and how it affects their development until adolescence to prevent possible dysfunctions. The co-development of oppositional defiant dimensions and OCP is studied in 563 children (49.7% female) from ages 6 to 13 years, assessed yearly with measures answered by parents and teachers. A 4-class model based on Latent Class Growth Analysis for three parallel processes (irritability, defiant, and OCP) was selected, which showed adequate fitting indexes. Class 1 (n = 349, 62.0%) children scored low on all the measures. Class 2 (n = 53, 9.4%) contained children with high OCP and low irritability and defiant. Class 3 (n = 108, 19.2%) clustered children with high irritability and defiant and low OCP. Class 4 (n = 53, 9.4%) clustered comorbid irritability, defiant, and OCP characteristics. The classes showed different clinical characteristics through development. The developmental co-occurrence of irritability and defiant plus obsessive-compulsive behaviors is frequent and adds severity through development regarding comorbidity, peer problems, executive functioning difficulties, and daily functioning. The identification of different classes when combining oppositional problems and OCP may be informative to prevent developmental dysfunctions and to promote good adjustment through development.

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Section: Introductionmentioning

confidence: 99%

Irritability, Defiant and Obsessive-Compulsive Problems Development from Childhood to Adolescence

Ezpeleta

Penelo

Navarro

et al. 2021

J Youth Adolescence

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“…To date, the duration of illness before treatment was the only stable predictor of long-term course in pediatric OCD [ 3 , 121 ]. Evidence from multiple studies suggests that longer untreated illness duration is associated with many unwanted outcomes, including higher rates of comorbidity and disability, greater family accommodation [ 122 , 123 ], poorer treatment response [ 124 , 125 , 126 ] and more delayed [ 127 ] and less frequent remissions [ 128 ].…”

Section: Primary Secondary and Tertiary Prevention Of Pediatric Ocdmentioning

confidence: 99%

“…Therefore, clinicians should provide patients with treatment as early as possible after symptoms have reached the severity of a clinical diagnosis of OCD. According to existing studies, it is not confirmed whether factors such as the severity of symptoms, family accommodation, family history of OCD and comorbidities are associated with a long-term course [ 3 , 121 ], but they are usually related to treatment response and symptom/diagnostic remission [ 129 , 130 , 131 ]. Improving existing evidence-based treatment protocols to enable patients to receive adequate, specific treatment early is essential to enhance tertiary prevention.…”

Section: Primary Secondary and Tertiary Prevention Of Pediatric Ocdmentioning

confidence: 99%

Early Identification and Intervention in Pediatric Obsessive-Compulsive Disorder

Liu

Fan

2023

Brain Sciences

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Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by persistent thoughts with subsequent repetitive behaviors. Interventions that are effective for adult OCD cannot simply be generalized to pediatric OCD, since OCD in children and adolescents usually has a different clinical presentation, etiology and course from adult OCD. Delayed and inadequate treatment is associated with a worse prognosis, making the need for early identification and intervention in pediatric OCD very urgent. In this paper, we reflected on the current constraints that make early interventions for pediatric OCD unpromoted and reviewed the approaches with potential application for early identification and early intervention in pediatric OCD, categorized by three-level prevention stages corresponding to a clinical staging model. Since the etiology of pediatric OCD is still unclear, primary prevention is most lacking, and early interventions for pediatric OCD are currently focused on the secondary prevention stage, which aims to prevent the conversion of obsessive-compulsive symptoms into full-blown OCD; tertiary prevention mostly focuses on the alleviation of mild to moderate OCD, while interventions for co-morbidities are still in their infancy. We closed by considering the important research questions on this topic.

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“…However, with the availability and accessibility of effective interventions, there has been a significant improvement in clinical outcomes. Recent meta-analyses of studies reporting on long-term course and outcome have shown that approximately half achieve clinical remission (Sharma et al 2014;Liu et al 2021). There is also evidence to suggest that rates of recurrence after achieving full remission in OCD could be relatively low, with 75% maintaining improvement at 5 years (Marcks et al 2011).…”

mentioning

confidence: 99%