Long‐Term Outcome of Patients With Idiopathic Ventricular Fibrillation: A Meta‐Analysis

Özaydın, Mehmet; Moazzami, Mitra; Kalantarian, M.P.H. Shadi; Lee, Hang; Mansour, Moussa; Ruskin, Jeremy N.

doi:10.1111/jce.12737

Cited by 27 publications

(24 citation statements)

References 51 publications

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“…The available data on appropriate ICD therapy in IVF patients show a high recurrence rate of ventricular arrhythmias, with appropriate ICD therapy in 11% to 45% in a mean follow-up of 3.2 to 5.3 years. 2,3,8,30,31 These results are comparable to our study and justify ICD implantation. In patients who experienced appropriate ICD therapy, a higher appropriate shock frequency was demonstrated in males, younger patients at the time of the index event, and patients who experienced symptoms before the index event.…”

Section: Icd Therapysupporting

confidence: 81%

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Visser

Heijden

Smagt

et al. 2016

Circ: Arrhythmia and Electrophysiology

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Background— Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest. Limited data are available on the long-term outcome of IVF patients. Methods and Results— In this retrospective cohort study, 107 consecutive patients with an initial diagnosis of IVF were analyzed (age at index event 40.4 years, 60% male). Missing diagnostic data were acquired during follow-up, including genetic testing, to exclude underlying disease. A specific diagnosis was revealed in 22 of 107 patients (21%) during a median follow-up of 10.2 years. Mortality rate was 9% in IVF patients (8/85). Appropriate implantable cardioverter–defibrillator therapy was delivered in 23 patients (29%) of 78 IVF patients with an implantable cardioverter–defibrillator, with a median of 3 appropriate shocks per patient. Conclusions— One fifth of the patients initially diagnosed with IVF reveal a specific diagnosis during long-term follow-up. Additional diagnostic testing, including genetic testing, contributes to the detection of specific diseases. The recurrence rate of ventricular arrhythmias in IVF patients is high. Our data show the importance of thorough follow-up and reassessment of diagnosis in IVF patients.

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Section: Icd Therapysupporting

confidence: 81%

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Visser

Heijden

Smagt

et al. 2016

Circ: Arrhythmia and Electrophysiology

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“…An implantable cardioverter defibrillator (ICD) is usually recommended for primary and secondary prevention of SCD in this population ( 3 , 4 ). However, around one third of patients with IVF, experience VF recurrence in the 5 years following diagnosis ( 5 ). VF ablation is recommended to prevent VF recurrence and reduce the number of ICD shocks ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Mapping and Ablation of Idiopathic Ventricular Fibrillation

Cheniti

Vlachos

Meo

et al. 2018

Front. Cardiovasc. Med.

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Idiopathic ventricular fibrillation (IVF) is the main cause of unexplained sudden cardiac death, particularly in young patients under the age of 35. IVF is a diagnosis of exclusion in patients who have survived a VF episode without any identifiable structural or metabolic causes despite extensive diagnostic testing. Genetic testing allows identification of a likely causative mutation in up to 27% of unexplained sudden deaths in children and young adults. In the majority of cases, VF is triggered by PVCs that originate from the Purkinje network. Ablation of VF triggers in this setting is associated with high rates of acute success and long-term freedom from VF recurrence. Recent studies demonstrate that a significant subset of IVF defined by negative comprehensive investigations, demonstrate in fact subclinical structural alterations. These localized myocardial alterations are identified by high density electrogram mapping, are of small size and are mainly located in the epicardium. As reentrant VF drivers are often colocated with regions of abnormal electrograms, this localized substrate can be shown to be mechanistically linked with VF. Such areas may represent an important target for ablation.

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“…ICD implantation in patients with IVF is justified by the high recurrence rate of ventricular arrhythmias, varying from 11% to 45%. 34,39,40 A meta-analysis showed recurrences of arrhythmias in 31% of the patients with IVF during a mean follow-up of 5.3 years. 40 Another study showed appropriate ICD therapy in 43% in a median follow-up of 8.8 years, but also included patients with ERS.…”

Section: Icd Therapy In Patients With Ivfmentioning

confidence: 99%

“…34,39,40 A meta-analysis showed recurrences of arrhythmias in 31% of the patients with IVF during a mean follow-up of 5.3 years. 40 Another study showed appropriate ICD therapy in 43% in a median follow-up of 8.8 years, but also included patients with ERS. 39 A recent study showed a lower rate of appropriate ICD therapy: 11% of patients with IVF received one or multiple appropriate shocks in a mean followup of 3.2 years, with a median time to first shock of 2.6 years.…”

Section: Icd Therapy In Patients With Ivfmentioning

confidence: 99%

Idiopathic Ventricular Fibrillation

Visser

Heijden

Doevendans

et al. 2016

Circ: Arrhythmia and Electrophysiology

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Long‐Term Outcome of Patients With Idiopathic Ventricular Fibrillation: A Meta‐Analysis

Abstract: In patients with IVF, this meta-analysis revealed an estimated recurrent event rate of 31% and a pooled mortality rate of 3.1% during an average of 5 years follow-up. The results of baseline electrophysiological studies are not predictive of future ventricular arrhythmias.

Cited by 27 publications

References 51 publications

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Mapping and Ablation of Idiopathic Ventricular Fibrillation

Idiopathic Ventricular Fibrillation

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