Long-term outcome of patients with chronic pancreatitis treated with micronutrient antioxidant therapy

Rupasinghe, Sukitha Namal; Siriwardena, Ajith K.

doi:10.1016/s1499-3872(16)60128-5

Cited by 5 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rupasinghe and Siriwardena 39 reported the effect of long-term of antioxidant therapy in CP (median, 3.5 years, up to 10 years). In their cohort of 30, with CP predominantly related to alcohol, no difference in opiate use at last recorded visit was noted compared with baseline.…”

Section: Resultsmentioning

confidence: 99%

“…Many nonanalgesic medications have been evaluated to reduce pain in CP. We found 4 studies of pancreatic enzymes (PEs) to treat pain in CP, [31][32][33][34] 9 studies of antioxidants, 26,[35][36][37][38][39][40][41][42] and 3 studies of other medications. [43][44][45] One study retrospectively reviewed outcomes of several different medications prescribed by treating physicians.…”

Section: Nonanalgesic Medicationsmentioning

confidence: 99%

See 1 more Smart Citation

Outpatient Pain Management in Children With Chronic Pancreatitis

et al. 2022

View full text Add to dashboard Cite

ObjectivesAlthough pain management is central to pediatric chronic pancreatitis (CP) care, no evidence-based guidelines exist. In this scoping systematic review, we sought promising strategies for CP pain treatment in children.MethodsWe systematically reviewed literature on pain management in children and adults with CP, and 2 conditions with similar pain courses: juvenile idiopathic arthritis and sickle cell disease.ResultsOf 8997 studies identified, 287 met inclusion criteria. There are no published studies of analgesic medications, antioxidants, dietary modification, integrative medicine, or regional nerve blocks in children with CP. In adults with CP, studies of nonopioid analgesics, pancreatic enzymes, and dietary interventions have mixed results. Retrospective studies suggest that endoscopic retrograde cholangiopancreatography and surgical procedures, most durably total pancreatectomy with islet autotransplant, improve pain for children with CP. Follow-up was short relative to a child's life. Large studies in adults also suggest benefit from endoscopic therapy and surgery, but lack conclusive evidence about optimal procedure or timing. Studies on other painful pediatric chronic illnesses revealed little generalizable to children with CP.ConclusionsNo therapy had sufficient high-quality studies to warrant untempered, evidence-based support for use in children with CP. Multicenter studies are needed to identify pain management “best practices.”

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Nonanalgesic Medicationsmentioning

confidence: 99%

Outpatient Pain Management in Children With Chronic Pancreatitis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Antioxidants are commonly used in the clinical treatment of CP and are expected to alleviate persistent abdominal pain caused by inflammation and other pathological reactions ( 99 ). However, recent studies have shown that antioxidant treatment cannot reduce pain in patients with CP ( 100 ), nor can it improve the quality of life of patients in other respects ( 101 ). Whether the use of antioxidants can change the inflammatory state of CP or delay the pathological process remains controversial.…”

Section: Research Progress Of Anti-inflammatory and Anti-fibrotic The...mentioning

confidence: 99%

The research progress of anti-inflammatory and anti-fibrosis treatment of chronic pancreatitis

Liu

Mao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Chronic pancreatitis (CP) is a chronic progressive inflammatory disease of the pancreas, caused by multiple factors and accompanied by irreversible impairment of pancreatic internal and external secretory functions. Pathologically, atrophy of the pancreatic acini, tissue fibrosis or calcification, focal edema, inflammation, and necrosis are observed. Clinical manifestations include recurrent or persistent abdominal pain, diarrhea, emaciation, and diabetes. In addition, CP is prone to develop into pancreatic cancer(PC) due to persistent inflammation and fibrosis. The disease course is prolonged and the clinical prognosis is poor. Currently, clinical treatment of CP is still based on symptomatic treatment and there is a lack of effective etiological treatment. Encouragingly, experiments have shown that a variety of active substances have great potential in the etiological treatment of chronic pancreatitis. In this paper, we will review the pathogenesis of CP, as well as the research progress on anti-inflammatory and anti-fibrotic therapies, which will provide new ideas for the development of subsequent clinical studies and formulation of effective treatment programs, and help prevent CP from developing into pancreatic cancer and reduce the prevalence of PC as much as possible.

show abstract

Medical Management of Pain in Chronic Pancreatitis

Singh

Drewes

2017

Dig Dis Sci

View full text Add to dashboard Cite

The medical management of pain in chronic pancreatitis continues to pose significant challenges for clinicians caring for these patients. There are increasing data, suggesting that pain in chronic pancreatitis is largely due to peripheral and central sensitization that evolves, over time, as a result of nociceptive afferent associated with chronic inflammation and fibrosis of the pancreas. In many instances, patients rapidly progress to requiring opioid analgesics for the adequate treatment of pain despite the unequivocal risks associated with the long-term use of these drugs. Centrally acting drugs, such as gabapentinoids, appear to be effective means of treating pain due to their inhibition of neurotransmitters involved in central sensitization, but side effects limit their use. The present review explores the evidence for various non-pharmacologic and pharmacologic treatments for pain in chronic pancreatitis.

show abstract

Long-term outcome of patients with chronic pancreatitis treated with micronutrient antioxidant therapy

Cited by 5 publications

References 18 publications

Outpatient Pain Management in Children With Chronic Pancreatitis

Outpatient Pain Management in Children With Chronic Pancreatitis

The research progress of anti-inflammatory and anti-fibrosis treatment of chronic pancreatitis

Medical Management of Pain in Chronic Pancreatitis

Contact Info

Product

Resources

About