Long-Term Outcome of Mustard/Senning Correction for Transposition of the Great Arteries in Sweden and Denmark

Vejlstrup, Niels; Sørensen, Kasper; Mattsson, Eva; Thilén, Ulf; Kvidal, Per-David; Johansson, Bengt; Iversen, Kasper; Søndergaard, Lars; Dellborg, Mikael; Eriksson, Peter

doi:10.1161/circulationaha.114.010770

Cited by 121 publications

(69 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Atrial switch surgery became the procedure of choice for D‐TGA until the 1980s, when it was progressively replaced by the arterial switch operation. Over 60% of patients with D‐TGA and Senning or Mustard baffles remain alive after 30 years of follow‐up, with most now in their third to fifth decades of life. Complications encountered in adult life are well characterized and include sinus node dysfunction, atrial arrhythmias, sudden death, systemic right ventricular dysfunction, tricuspid regurgitation, subvalvular pulmonary stenosis, and baffle obstructions and leaks …”

Section: Introductionmentioning

confidence: 99%

Late Onset Postcapillary Pulmonary Hypertension in Patients With Transposition of the Great Arteries and Mustard or Senning Baffles

Chaix

Dore

Mercier

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundThere is a paucity of data regarding late‐onset pulmonary hypertension (PH) in patients with transposition of the great arteries and atrial switch surgery.Methods and ResultsA retrospective cohort study was conducted on 140 adults with transposition of the great arteries and atrial switch surgery, age 37.3±7.8, 37.1% female, in order to assess the prevalence and characteristics of late‐onset PH and explore associated factors. Patients were followed for a median of 32.3 years after atrial switch surgery and 10.0 years after their first referral visit. PH was detected in 18 of 33 (54.5%) patients who had invasive hemodynamic studies. Average age at diagnosis of PH was 33.9±8.1 years. PH was postcapillary in all, with a mean pulmonary artery pressure of 36±12 mm Hg and mean pulmonary capillary wedge pressure of 28±8 mm Hg. PH was diagnosed in 13 of 17 (76.5%) patients who had cardiac catheterization for heart failure or decreased exercise tolerance. In multivariable analyses, systemic hypertension (odds ratio 9.4, 95% confidence interval 2.2‐39.4, P=0.002) and heart failure or New York Heart Association class III or IV symptoms (odds ratio 49.8, 95% confidence interval 8.6‐289.0, P<0.001) were independently associated with PH. Patients with PH were more likely to develop cardiovascular comorbidities including atrial (P=0.001) and ventricular (P=0.008) arrhythmias, require hospitalizations for heart failure (P<0.001), and undergo tricuspid valve surgery (P<0.001). Mortality was significantly higher in patients with PH (hazard ratio 9.4, 95% confidence interval 2.1‐43.0], P<0.001).ConclusionsLate‐onset postcapillary PH is highly prevalent in adults with transposition of the great arteries and atrial switch surgery and is associated with an adverse prognosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Late Onset Postcapillary Pulmonary Hypertension in Patients With Transposition of the Great Arteries and Mustard or Senning Baffles

Chaix

Dore

Mercier

et al. 2017

JAHA

View full text Add to dashboard Cite

show abstract

“…Patients with a systemic right ventricle due to transposition of the great arteries (TGA) or congenitally corrected transposition of the great arteries (ccTGA) carry a life-long risk of systemic right ventricular dysfunction (Graham et al, 2000; Vejlstrup et al, 2015) and heart failure. The development of systemic ventricular dysfunction is reflected in the growing number of case series describing the outcome of VAD support for these patients (Joyce et al, 2010; Peng et al, 2014; Maly et al, 2015).…”

Section: Congenital Heart Disease In the Two Ventricle Circulationmentioning

confidence: 99%

The Total Artificial Heart in End-Stage Congenital Heart Disease

Villa

Morales

2017

Front. Physiol.

View full text Add to dashboard Cite

The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (CHD), despite the fact that the number of patients with end stage CHD has grown due to improvements in surgical and medical care. VAD use has been limited in patients with CHD and end stage heart failure due to anatomic (systemic right ventricle, single ventricle, surgically altered anatomy, valve dysfunction, etc.) and physiologic constraints (diastolic dysfunction). The total artificial heart (TAH), which has right and left sided pumps that can be arranged in a variety of orientations, can accommodate the anatomic variation present in CHD patients. This review provides an overview of the potential use of the TAH in patients with CHD.

show abstract

“…Egy másik dán-svéd közös tanulmányban a két műtéti technika hosszú távú utánkövetését vizsgálták [20]. Azt találták, hogy a hosszú távú túlélés nagyobb összefüggést mutat a JK-és a tricuspidalisbillentyű-funkcióval, mint a műtét típusával és annak időpontjával.…”

Section: Megbeszélésunclassified

A teljes nagyér-transzpozíción átesett betegek Senning- és Mustard-féle műtéti megoldásának hosszú távú utánkövetése. Eredmények a CSONGRAD Regiszterből

et al. 2016

View full text Add to dashboard Cite

Bevezetés: A teljes nagyér-transzpozíció az egyik leggyakoribb, cyanosissal járó veleszületett szívfejlődési rendellenesség. Célkitűzés: A szerzők célja a teljes nagyér-transzpozíció miatt Senning-és Mustard-féle műtéten átesett betegeik hosszú távú túlélésének, funkcionális stádiumának, aritmológiai kontrolljának és életminőségének elemzése és össze-hasonlítása volt. Módszer: A vizsgálatban 85, teljes nagyér-transzpozíció miatt operált beteg vett részt, közülük 37 esetben Senning-műtét, míg 48 esetben Mustard-műtét történt. Valamennyi esetben utánkövetéses vizsgálatot vé-geztek. Eredmények: A több évtizedes utánkövetés sikeraránya 74%-nak bizonyult. A 31 utánkövetett Senning-műtött közül 12-en hunytak el a követés során (39%), míg a 32 Mustard-műtött közül 16-an haláloztak el (50%) (p = 0,45). Nem volt különbség a szívelégtelenség és az aritmiák jellemzői között sem a két betegcsoportban. Az életminőséget és a funkcionális kapacitást jellemző paraméterek kedvezőbbnek bizonyultak a Senning-műtött betegekben. Követ-keztetések: A Mustard-és Senning-műtött TGA-betegek mortalitásában és morbiditásában szignifikáns különbség nem volt igazolható. A Senning-műtött betegek életminősége és funkcionális kapacitása a hosszú távú követés eredményei alapján kedvezőbb. Orv. Hetil., 2016, 157(3), 104-110. Kulcsszavak: teljes nagyér-transzpozíció, utánkövetés Long-term follow-up of patients with transposition of the great arteries following Senning and Mustard operations -Results from the CSONGRAD RegistryIntroduction: Transposition of the great arteries is one of the most common cyanotic congenital heart diseases. Aim: The present study aimed to examine and compare long-term survival, functional grading, arrhytmologic and quality of life control in patients with transposition of the great arteries following Senning-and Mustard-operations. Methods: The present study comprised 85 patients with transposition of the great arteries, of whom Senning-operation was performed in 37 cases and Mustard-operation in 48 subjects. Follow-up study was performed in all cases. Results: The success rate of long-term follow-up proved to be 74%. Twelve out of the 31 Senning-operated and 16 out of 32 Mustard-operated patients died during the follow-up (39% vs. 50%, p = 0.45). Neither features of heart failure, nor those of arrhythmias showed differences between the groups, but parameters of quality of life and functional capacity proved to be favourable in Senning-operated patients. Conclusions: There is no significant difference in mortality and morbidity of patients with transposition of the great arteries following Mustard-and Senning-operations. Regarding to long-term follow-up quality of life and functional capacity of Senning-operated patients were more favourable.

show abstract

Long-Term Outcome of Mustard/Senning Correction for Transposition of the Great Arteries in Sweden and Denmark

Abstract: Background-The atrial switch operation, the Mustard or Senning operation, for the transposition of the great arteries (TGA) was introduced in the late 1950s and was the preferred surgery for TGA until the early 1990s.

Cited by 121 publications

References 21 publications

Late Onset Postcapillary Pulmonary Hypertension in Patients With Transposition of the Great Arteries and Mustard or Senning Baffles

Late Onset Postcapillary Pulmonary Hypertension in Patients With Transposition of the Great Arteries and Mustard or Senning Baffles

The Total Artificial Heart in End-Stage Congenital Heart Disease

A teljes nagyér-transzpozíción átesett betegek Senning- és Mustard-féle műtéti megoldásának hosszú távú utánkövetése. Eredmények a CSONGRAD Regiszterből

Contact Info

Product

Resources

About