Long‐Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors

Haugvik, Sven-Petter; Marangos, Irina Pavlik; Røsok, Bård I.; Pomianowska, Ewa; Gladhaug, Ivar P.; Mathisen, Øystein; Edwin, Bjørn

doi:10.1007/s00268-012-1893-5

Cited by 56 publications

(63 citation statements)

References 197 publications

(302 reference statements)

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“…A laparoscopic approach can be used in localized imaged RF p-NETs [1;171–173]. In patients with MEN1 with NF-p-NETs ≤2 cm or with on imaging studies, routine surgical exploration continues not to be generally recommended.…”

Section: Surgery For F-p-nets and Nf-p-nets (See Algorithm)mentioning

confidence: 99%

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

et al. 2016

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Section: Surgery For F-p-nets and Nf-p-nets (See Algorithm)mentioning

confidence: 99%

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

et al. 2016

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“…In order to allow for subdivision of the tumor samples analyzed, the following tumor characteristics were registered: degree of cell proliferation as indicated by the value of Ki-67 (< or ≥5%), the presence/absence of synchronous distant metastases, and the size of the primary tumor (< or ≥3.5 cm). We used a Ki-67 cut-off value of 5% as this is a known prognostic predictor (17,18). The cut-off value of the size of the primary tumor was chosen in such a way that an equal amount of analyzed samples were below and above this value.…”

Section: Methodsmentioning

confidence: 99%

Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms

et al. 2014

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The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly understood. To gain insight into the genetic mechanisms underlying this tumor entity, we performed genome-wide screening of 16 surgical specimens from 15 patients with sporadic PNEN, combining G-band karyotyping and high resolution comparative genomic hybridization (HR-CGH). G-banding revealed abnormal karyotypes in 2 of 10 tumor samples analyzed. DNA copy number changes were detected in 13 samples, whereas three tumors showed a balanced genome. Gains were more frequent than losses in the nonfunctioning tumors (n=13). Common gains were scored at 5p12–13, 4q13–24, 5p15, 5q11–31, and 9q21–22. Common losses were scored at 11p11, 11p14–15, 11q23, 11p12–13, and 11q22. The average number of copy aberrations (ANCA index) was 12 for 13 nonfunctioning primary tumors, 4.8 for the nonfunctioning tumors with low Ki-67 (≥5%), 21.2 for the tumors with high Ki-67 (<5%), 2.5 for small tumors (<3.5 cm), and 17.8 for large tumors (≥3.5 cm). There was a statistically significant difference in the ANCA index between the groups defined by Ki-67 and tumor size. Nonfunctioning tumors with low Ki-67, no distant metastasis and small size had few aberrations detected by HR-CGH, but frequent loss of material from chromosomal band 11p11. The present study indicates the existence of distinct cytogenetic patterns in sporadic nonfunctioning PNEN. Loss of chromosomal band 11p11 might indicate a primary pathogenetic event in these tumors.

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“…Tumors in the head of the pancreas can be enucleated safely, whereas laparoscopic resection of PNET in the pancreatic body and/or tail may be favored over enucleation [99][100][101].…”

Section: Surgical Therapymentioning

confidence: 99%

Pancreatic neuroendocrine tumors

Karakaxas¹,

Gazouli²,

Liakakos³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

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Pancreatic neuroendocrine tumors (PNETs) share a unique genetic identity, functional behavior, and clinical course. Compared with tumors of the exocrine pancreas, they are rare and show a different biologic behavior and prognosis. On the basis of data from recent studies, all PNETs, outside of small insulinomas, should be considered potentially malignant and treated accordingly. Untreated tumors have a high possibility to grow locally into adjacent structures or spread to distant organs. Although surgical excision irrespective of tumor functioning or nonfunctioning state remains the cornerstone of therapy, providing the best disease-free and survival rates to date, the understanding of the genetic nature of the disease yields new 'targets' to consider in drug development. The aim of this review is to summarize all recent advances of genetic research and new drug development in terms of PNETs, especially their genetic identity and subsequent alterations leading to the development of near or total malignant activity, and the new medical treatment strategies of this potentially curable disease on the basis of therapeutical agents acting, where possible, at the genetic level.

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Long‐Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors

Abstract: LS of PNET is feasible with acceptable morbidity and a good overall disease-specific long-term prognosis.

Cited by 56 publications

References 197 publications

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms

Pancreatic neuroendocrine tumors

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