Long-term outcome of image-guided percutaneous radiofrequency ablation of lung metastases: an open-labeled prospective trial of 148 patients

Chua, Terence C.; Sarkar, Amitava; Saxena, Akshat; Glenn, Derek; Zhao, Jinbo; Morris, David L.

doi:10.1093/annonc/mdq098

Cited by 80 publications

(53 citation statements)

References 24 publications

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“…Lencioni et al (16) reported that overall survival rate was 92% at one year and 64% at two years for a group of 20 patients with noncolorectal pulmonary metastases. In another study that demonstrated long-term outcome of RF ablation of lung metastases, three-and five-year overall survival rates were 60% and 45%, respectively (17). Similarly, our overall survival rates for the subgroup of colorectal lung metastases of 16 patients were parallel to those of many other reports in the literature.…”

Section: Discussionsupporting

confidence: 86%

Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors

Akhan¹,

Güler²,

Akıncı³

et al. 2015

Diagn Interv Radiol

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P rimary lung cancer is the leading cause of cancer-related death worldwide (1). Treatment of primary lung cancers includes surgical resection, radiation therapy, chemotherapy, and thermal ablation. Surgical resection remains the treatment of choice for patients with early stage non-small cell lung cancer (NSCLC) (2). However, primary lung cancers are generally diagnosed in advanced stages. Moreover, due to the high incidence of associated comorbidities and limited pulmonary reserve, most patients are considered ineligible for surgery (3,4).In addition to primary cancers, lungs are the second most frequent site of metastatic disease. In selected patients with metastatic lung cancer, surgical resection is the preferred treatment. However, even patients who have undergone a complete resection have a high incidence of recurrence and may require multiple surgeries (5). Repeat thoracotomy leads to further removal of functional pulmonary tissue. Surgical resection might not be possible in patients with certain comorbidities and limited pulmonary reserve.Patients with pulmonary colorectal metastases constitute a significant portion of metastatic lung tumor group. Approximately 10% of patients with colorectal cancer develop pulmonary metastases during the course of disease (6). It has been reported that in patients with limited colorectal pulmonary metastases and no extrapulmonary disease, five-year survival following surgical resection is approximately 35%-45% (7). However, many patients are not suitable candidates for surgery. PURPOSEWe aimed to evaluate the survival benefit achieved with radiofrequency (RF) ablation of primary and metastatic lung tumors and determine significant prognostic factors for recurrence-free survival. METHODSForty-nine patients with lung cancer (10 primary and 39 metastatic) underwent computed tomography-guided percutaneous RF ablation between June 2005 and October 2013. A total of 112 tumors (101 metastatic and 11 primary non-small cell lung cancer) were treated with RF ablation. Tumor diameter ranged from 0.6 to 4 cm (median 1.5 cm). Effectiveness of treatment, complications, and survival were analyzed. RESULTSPrimary success rate was 79.5% and local tumor progression occurred in 23 tumors. Among tumors showing progression, 10 were re-treated with RF ablation and secondary success rate was 87.5%. One-, two-, and three-year overall survival rates of 10 patients with primary lung cancer were 100%, 86%, and 43%, respectively. One-, two-, three-, four-, and five-year overall survival rates for 39 patients with metastatic lung tumors were 90%, 73%, 59%, 55%, and 38%, respectively. One-, two-, three-, and four-year overall survival rates for 16 patients with colorectal pulmonary metastases were 94%, 80%, 68%, and 23%, respectively. Complications occurred in 30 sessions (24.6%). Pneumothorax occurred in 19 sessions with seven requiring image-guided percutaneous chest tube drainage. Tumor status (solitary or multiple) and presence of extrapulmonary metastasis at initial RF ablation were significa...

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Section: Discussionsupporting

confidence: 86%

Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors

Akhan¹,

Güler²,

Akıncı³

et al. 2015

Diagn Interv Radiol

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show abstract

“…These are intricate, highly efficient endogenous pathways in cardiac and smooth muscle cells, renal tubular, mesenchymal, as well as inflammatory cells infiltrating various tissues. Contribution of alternative pathways involving chymases, tonins, neutral endopeptidases, and aminopeptidases can significantly vary relative to classic RAS in a pathologic setting (Carey and Siragy, 2003;Chua et al, 2010;Wasse et al, 2012;Naffah-Mazzacoratti et al, 2014;Su, 2014).…”

Section: Intracellular Renin-angiotensin System and Alternative Pamentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli

et al. 2015

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“…The major complication was pneumothorax requiring chest tube placement, which occurred in (11.9%). Minor complications (19.4%), including self-limited minor pneumothorax, slight cough, a low-grade fever, and local pain at the puncture site, were well tolerated, Chua et al, [24] who reported that there was no treatment-related mortality. Sixty-six patients (45%) had a pneumothorax, 16 patients (11%) had a pleural effusion, 10 patients (7%) had consolidation, 1 patient (1%) developed bleeding and 12 patients (8%) had pleuritic chest pain, Lee et al, [19] who reported pneumothorax 7%, acute respiratory distress syndrome 3%, small pneumothorax 23%, subcutaneous emphysema 10%, obstructive pneumonia 7%, fever 7%, pleural effusion 7% and hemoptysis 3%.…”

Section: Discussionmentioning

confidence: 93%

“…In a study done by Li et al, [23] 31 patients (63.3%) had a complete response, 12 patients (24.5%) had a partial response, six patients (12.2%) had stable disease, and no patients had progressive disease. In a study done by Chua et al, [24] of 148 patients treated, 66 patients (46%) had a complete response, 38 patients (26%) had a partial response, 57 patients (39%) had stable disease and 23 patients (16%) had progressive disease. Sun et al, [25] who used microwave ablation in 29 cases of peripheral lung cancer, complete response in 27%, partial response in 48%, stable in 13% and progression in 10% after microwave ablation.…”

Section: Discussionmentioning

confidence: 96%

Hot Saline Thermoablation of Peripheral Non Small Cell Lung Cancer safety and Efficacy: a Pilot Study

MK¹,

Hewidy²

2017

IJRDM

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Long-term outcome of image-guided percutaneous radiofrequency ablation of lung metastases: an open-labeled prospective trial of 148 patients

Cited by 80 publications

References 24 publications

Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors

Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli

Hot Saline Thermoablation of Peripheral Non Small Cell Lung Cancer safety and Efficacy: a Pilot Study

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