Objective: Cardiovascular disease have a large disease burden in developing countries. Percutaneous coronary intervention (PCI) is one of the modalities used to restore the blood flow in atherosclerotic coronary vessels. The aim of this randomized controlled trial was to evaluate the safety of same-day discharge compared to overnight hospital stay after low-risk elective PCI in a tertiary care hospital in Pakistan.Results: From September 2014 to September 2015, a total of 210 patients who underwent low-risk PCI were randomized to overnight stay or same-day discharge. Primary endpoint of the study was a major adverse event, a composite of death, myocardial infarction, repeat revascularization, rehospitalization, and any access site complications (major bleeding or hematoma) after the procedure. No major adverse events were noted within 24 hours in either group. The only reported adverse event was myocardial infarction secondary to stent thrombosis on the third day after PCI in the same-day discharge group. No mortality or access site complications occurred in either group. In our cohort, same-day discharge after low-risk PCI was safe and should be considered for certain patients to eliminate the cost of an overnight hospital stay.clinical trial registry number: NCT02214082. Registered on 11th August 2014