Long-term outcome of children with oesophageal atresia type III

Abstract

The high frequency of late sequelae in EA type III justifies regular and multidisciplinary follow-up through to adulthood.

Postoperative Complications and Functional Outcome after Esophageal Atresia Repair: Results from Longitudinal Single-Center Follow-Up

“…8 Because of its rarity and complex nature, EA/TEF represents one of the major therapeutic challenges not only in modern pediatric surgery but also for other specialties involved due to serious short-and long-term morbidities. [13][14][15][16][17][18] Our results were consistent with previous studies indicating that despite precise esophageal reconstruction and excellent postoperative care, early and late complications frequently occur and must be dealt with. [19][20][21][22] The definition of possible complications is however lacking standardization, which makes an exact comparison with the literature difficult and thus results in highly variable incidence rates.…”

“…9,10 Today, improved survival of newborns with EA/TEF is likely related to multiple factors including advances in neonatal intensive care and anesthesia, refined surgical techniques, parenteral nutrition, and antibiotics. 11,12 However, early [13][14][15] and late [16][17][18] postoperative morbidities frequently occur after initial repair of EA/TEF despite excellent surgical and neonatal management, and can be associated with impaired outcomes. Early recognition and treatment of potential complications is therefore essential in order to prevent poor long-term results.…”

Growth and development after oesophageal atresia surgery: Need for long-term multidisciplinary follow-up

“…Long-term growth data Growth has mainly been described in cross-sectional studies (6)(7)(8)(9)(10)(11) and retrospective evaluations of medical charts(12-14). Gischler and co-workers evaluated longitudinal growth up till five years in a prospectively followed cohort of 23 OA-patients born from 1999 onwards; all but one patient had a type C-OA (15).…”

Lung maturity in esophageal atresia: Experimental and clinical study

“…Although the respiratory symptoms suffered by children born with EA-TEF may be explained by GER, tracheomalacia and surgical complications, or even by intrauterine growth retardation or prematurity, several long term studies on respiratory function in children, adolescents or adults with the malformation did not find a clear correlation between the abovementioned conditions and some of the respiratory symptoms [5,14]. We postulate the hypothesis that these might have a fetal origin since disturbed regulation during critical periods of early life may lead to developmental adaptations potentially responsible for permanent structural, physiological and epigenetic changes with lifetime consequences [15].…”