Long‐term outcome of an intra‐articular allograft technique for treatment of spontaneous cranial cruciate ligament rupture in the dog

Biskup, Jeffery J.; Balogh, Daniel G.; Scott, Ruth; Conzemius, Michael G.

doi:10.1111/vsu.12653

Cited by 11 publications

(19 citation statements)

References 54 publications

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“…All DDFT allografts were obtained from a commercial source (Veterinary Transplant Services, Kent, Washington) with standard operating procedures regarding collection, processing, and storage of grafts as previously described . Whole DDFT tendons were decellularized by using a protocol based on a published method …”

Section: Methodsmentioning

confidence: 99%

“…The dog was prepared with a standard hanging limb technique. The surgical procedure was completed through a medial arthrotomy including pretensioning of the grafts to 40 N, as previously reported . Meniscal tears, when present, were treated with a partial meniscectomy of the injured portion.…”

Section: Methodsmentioning

confidence: 99%

“…The tibia was drilled from the insertion of the CCL at an angle of 55° to the long axis of the tibia in the frontal plane, exiting the medial tibial cortex. The DDFT was secured in the femoral tunnel by looping it over a cross pin (3‐mm TransFix Implant; Arthrex Vet Systems, Naples, Florida), as previously described . As the graft exited the tibial tunnel, the stifle was placed in a neutral position (~135°), tension was applied to the graft by hand, and the stifle was secured to the medial tibial cortex by using a single screw and spiked washer (4.5‐mm Bi‐Cortical Post and spiked washer; Arthrex Vet Systems).…”

Section: Methodsmentioning

confidence: 99%

“…In veterinary medicine, intra‐articular repairs were historically more commonly performed and preferred in large breeds dogs with acute CCL injuries but have fallen out of favor because of inferior clinical outcomes . Recently, intra‐articular repairs have been re‐explored as a possible solution to achieving stabilization of the stifle after CCL injury because more recently described grafts and fixation methods may be stronger …”

Section: Introductionmentioning

confidence: 99%

“…The repairs immediately eliminated cranial drawer, but in vivo placement had an unacceptably high complication rate. Use of a deep digital flexor tendon (DDFT) allograft provided promising results in an initial pilot study of 10 dogs . In this study, DDFT allografts were secured in bone tunnels at the footprints of the CCL with a cross pin, interference screw, and spiked washer.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term arthroscopic assessment of intra‐articular allografts for treatment of spontaneous cranial cruciate ligament rupture in the dog

Biskup

Conzemius

2020

Veterinary Surgery

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Objective: To assess the 12-month survival of intra-articular, decellularized allografts for the treatment of cranial cruciate ligament disease (CCLD) in dogs. Study design: Prospective case series.Animals: Twenty client-owned dogs with spontaneous CCL rupture. Methods: Affected stifles were treated solely by implantation of an intra-articular, decellularized, deep digital flexor tendon allograft. Functional outcome was evaluated at baseline and at 6 and 12 months after surgery with the Liverpool Osteoarthritis for Dogs questionnaire and force platform gait analysis. At 12 months after surgery, dogs underwent arthroscopy to visually assess the allografts.Results: Scores on owner questionnaires (improved 62.5%; P = .005) and ground reaction forces (improved 34.4%; P = .017) were improved in all dogs 12 months after surgery. Dogs with an intact graft (IG) were more likely to have a successful outcome compared with dogs with a torn graft (P = .011).According to arthroscopy, 45% of grafts seemed to survive at 12 months after surgery. Conclusion: About half of intra-articular allografts survived 12 months after implantation in CCL-deficient stifles. Dogs with IG had successful outcomes at 12 months after surgery according to assessment by force platform gait analysis. Clinical significance: These results preclude immediate clinical application but provide evidence to justify further investigation of intra-articular grafts as a repair option for CLLD.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long‐term arthroscopic assessment of intra‐articular allografts for treatment of spontaneous cranial cruciate ligament rupture in the dog

Biskup

Conzemius

2020

Veterinary Surgery

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Complications Associated with Intraarticular Repair Techniques

Biskup¹,

Conzemius²

2021

Complications in Canine Cranial Cruciate Ligament Surgery

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Functional Anatomy of the Craniomedial and Caudolateral Bundles of the Cranial Cruciate Ligament in Beagle Dogs

Tanegashima

Edamura

Akita

et al. 2019

Vet Comp Orthop Traumatol

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Objective The aim of this study was to investigate detailed functional anatomy of the craniomedial bundle (CrMB) and caudolateral bundle (CdLB) of cranial cruciate ligament (CrCL) for application of intra-articular anatomical reconstruction in dogs. Materials and Methods Twelve stifle joint of 12 Beagle cadavers were used. Anatomical characteristics of femoral attachment regions of the CrCL were determined. Then, the location and area of the footprints of the CrMB and CdLB were objectively measured. Each bundle was equally divided into four fibre bundles, and changes in the fibre arrangement were recorded during stifle range of motion. Additionally, the tension of each fibre bundle at various stifle joint angles was objectively measured. Results The attachment region of the CrCL clearly differed from that reported in humans. The centre of the CdLB attachment site was located craniodistal to that of the CrMB on the femur and slightly caudal to that of the CrMB on the tibia. The area of the CrMB on the femoral and tibial attachment sites was larger than that of the CdLB. During stifle range of motion, each divided fibre bundle in the CrMB and CdLB was twisted intricately. The tension of the CrMB was higher than that of CdLB. The central part of the CrMB was always tense during stifle range of motion. Clinical Significance These results may contribute to the application of anatomical reconstruction surgery for CrCL deficient stifle in dogs.

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Long‐term outcome of an intra‐articular allograft technique for treatment of spontaneous cranial cruciate ligament rupture in the dog

Abstract: Intra-articular repair using a decellularized allograft can provide functional clinical outcomes in dogs with CCL disease. A better understanding of long-term engraftment after this procedure is needed.

Cited by 11 publications

References 54 publications

Long‐term arthroscopic assessment of intra‐articular allografts for treatment of spontaneous cranial cruciate ligament rupture in the dog

Long‐term arthroscopic assessment of intra‐articular allografts for treatment of spontaneous cranial cruciate ligament rupture in the dog

Complications Associated with Intraarticular Repair Techniques

Functional Anatomy of the Craniomedial and Caudolateral Bundles of the Cranial Cruciate Ligament in Beagle Dogs

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