Long-term outcome in neuroZika

Lannuzel, Annie; Fergé, Jean-Louis; Lobjois, Quentin; Signaté, Aïssatou; Rozé, B.; Tressières, Benoît; Madec, Yoann; Poullain, Pascale; Herrmann, Cécile; Najioullah, Fatiha; McGovern, Eavan; Savidan, Anne-Charlotte; Valentino, Ruddy; Breurec, Sébastien; Césaire, Raymond; Hirsch, Étienne C.; Lledo, Pierre−Marie; Thiéry, Guillaume; Cabie, André; Lazarini, Françoise; Roze, Emmanuel

doi:10.1212/wnl.0000000000007536

Cited by 30 publications

(10 citation statements)

References 46 publications

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“…Clinical evidences have shown that ZIKV may result in encephalitis and other myelitis, attesting our results (Muñoz et al, 2016;Da Silva et al, 2017;Pereira et al, 2017;Tolosa et al, 2017;Capasso et al, 2019). As previously observed by Lannuzel et al (2019), long-term sequelae were frequenting in children and adult patients from ZIKV-outbreak in Guadeloupe and Martinique islands. They identified not only Guillain-Barré syndrome (GBS), but other disorders involving both, central and peripheral nervous system, as encephalitis or encephalomyelitis, in addition to nerve palsies.…”

Section: Molecular Markers Of Potential Clinical Outcomessupporting

confidence: 91%

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

et al. 2022

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Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment.

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Section: Molecular Markers Of Potential Clinical Outcomessupporting

confidence: 91%

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

et al. 2022

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“…However, the disease has been linked to several neurologic manifestations in children and adults such as Guillain-Barré syndrome and peripheral nerve involvement, and ophthalmic complications such as retinal and optic nerve abnormalities. Vertical transmission has been associated with spontaneous abortion and stillbirth, and also with congenital malformations in newborns including but not limited to microcephaly [5,15,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Congenital Zika syndrome: A systematic review

et al. 2020

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Background The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. Methods and findings A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. Conclusions Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols.

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“…Although experimental models and human studies have shown that ZIKV has an exquisite affinity for human neural progenitor cells that might explain pre-natal neural damage (8), the mechanisms that induce neuronal damage and explains other neurological manifestations in adults are not clearly understood. Further, severe manifestations in adults and infants have received considerable attention given its conspicuousness and ramifications but it is reasonable to hypothesize that ZIKV infection may cause subclinical or mild disease, which might include neurocognitive impairment during acute infection or over the long term (9)(10)(11). In this study, we aimed to explore whether ZIKV infection may cause subclinical or mild neurocognitive alterations, estimate its frequency and duration, and to compare it to other acute illnesses in a cohort of people with suspected Zika infection in Mexico.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Impact of Zika and Dengue Virus Infection, and Other Acute Illnesses of Unidentified Origin on Cognitive Functions in a Prospective Cohort in Chiapas Mexico

et al. 2021

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Zika has been associated with a variety of severe neurologic manifestations including meningitis and encephalitis. We hypothesized that it may also cause mild to subclinical neurocognitive alterations during acute infection or over the long term. In this observational cohort study, we explored whether Zika cause subclinical or mild neurocognitive alterations, estimate its frequency and duration, and compare it to other acute illnesses in a cohort of people with suspected Zika infection, in the region of Tapachula in Chiapas, Mexico during 2016–2018. We enrolled patients who were at least 12 years old with suspected Zika virus infection and followed them up for 6 months. During each visit participants underwent a complete clinical exam, including a screening test for neurocognitive dysfunction (Montreal Cognitive Assessment score). We enrolled 406 patients [37 with Zika, 73 with dengue and 296 with other acute illnesses of unidentified origin (AIUO)]. We observed a mild and transient impact over cognitive functions in patients with Zika, dengue and with other AIUO. The probability of having an abnormal MoCA score (<26 points) was significantly higher in patients with Zika and AIUO than in those with dengue. Patients with Zika and AIUO had lower memory scores than patients with dengue (Zika vs. Dengue: −0.378, 95% CI−0.678 to −0.078; p = 0.014: Zika vs. AIUO 0.264, 95% CI 0.059, 0.469; p = 0.012). The low memory performance in patients with Zika and AIUO accounts for most of the differences in the overall MoCA score when compared with patients with dengue. Our results show a decrease in cognitive function during acute illness and provides no evidence to support the hypothesis that Zika might cause neurocognitive alterations longer than the period of acute infection or different to other infectious diseases. While effects on memory or perhaps other cognitive functions over the long term are possible, larger studies using more refined tools for neurocognitive functioning assessment are needed to identify these.Trial Registration: NCT02831699.

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Long-term outcome in neuroZika

Cited by 30 publications

References 46 publications

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

Congenital Zika syndrome: A systematic review

Comparison of the Impact of Zika and Dengue Virus Infection, and Other Acute Illnesses of Unidentified Origin on Cognitive Functions in a Prospective Cohort in Chiapas Mexico

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