Long‐term outcome in adolescent‐onset generalized genetic epilepsies

Abstract

Long-term outcome was shown to be highly similar across all subsyndromes of adolescent-onset GGE. Even in a selection of difficult-to-treat epilepsy patients still attending an adult epilepsy clinic, most become seizure-free. To confirm these findings, prospective studies are needed.

Pharmacological outcomes in teenagers with newly diagnosed epilepsy: A 30‐year cohort study

“…5 This study aimed to evaluate longterm outcomes in teenagers with different epilepsies. 5 This study aimed to evaluate longterm outcomes in teenagers with different epilepsies.…”

“…Few observational studies have evaluated pharmacological outcomes in teenagers with different epilepsies; some studies have included teenagers with adults 4 or focused on particular epilepsy types. 5 This study aimed to evaluate longterm outcomes in teenagers with different epilepsies. Where possible, treatment outcomes in this population were compared to previously published outcomes in adults.…”

Use of brivaracetam in genetic generalized epilepsies and for acute, intravenous treatment of absence status epilepticus

“…However, AEDs play a central and crucial role in the treatment of these patients, as (1) a substantial number of GGE patients require anticonvulsant treatment for an extended period of time and (2) there is no surgical treatment option for these patients. Furthermore, in contrast to the perceived excellent prognosis, up to 20% of GGE patients remain refractory to AEDs . Overall, patients with drug‐refractory epilepsies are affected by increased morbidity and mortality, social stigma, reduced employment opportunities, and impaired quality of life for both themselves and their caregivers .…”

“…Furthermore, in contrast to the perceived excellent prognosis, up to 20% of GGE patients remain refractory to AEDs. 6,7 Overall, patients with drug-refractory epilepsies are affected by increased morbidity and mortality, social stigma, reduced employment opportunities, and impaired quality of life for both themselves and their caregivers. [8][9][10][11][12] Introduction of a new AED provides an opportunity to achieve better seizure control for some patients.…”

Absence epilepsy beyond adolescence: an outcome analysis after 45 years of follow-up

“…Comparing subjects with childhood versus juvenile onset and pyknoleptic versus non-pyknoleptic course of absence epilepsy, there were no relevant differences in terms of marital status, parenthood, employment status, psychiatric comorbidity, alcohol and tobacco use. University entrance qualification was achieved by 38% of patients with absence epilepsy, whereas patients with generalised tonic–clonic seizures alone or juvenile myoclonic epilepsy from the same study cohort had higher rates (61% and 65%, respectively) 28. Among patients with absence epilepsy, those with pyknoleptic absence seizures were less likely to achieve university entrance qualification than those with non-pyknoleptic absence seizures, although statistically not significant.…”