Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy: a retrospective, multi-centre, International Extranodal Lymphoma Study Group study

Wirth, Andrew; Gospodarowicz, Mary K.; Aleman, Berthe M.P.; Bressel, Mathias; Ng, Andrea K.; Chao, Michael; Hoppe, Richard T.; Thiéblemont, Catherine; Tsang, Richard W.; Moser, Lutz; Specht, Lena; Szpytma, Teresa; Lennard, Anne; Seymour, John F.; Zucca, Emanuele

doi:10.1093/annonc/mds623

Cited by 77 publications

(67 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The existing literature has drawn different conclusions about the optimal treatment regimen for this disease. In addition, there is no consensus on the prognostic value of disease site, stage, risk groups, and other patient characteristics at diagnosis (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Radiation therapy as single-modality treatment is highly effective for local control and organ preservation of early-stage extranodal MZL.…”

Section: Resultsmentioning

confidence: 99%

Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

Teckie

Lovie

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

Teckie

Lovie

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

“…52, [115][116][117] Literature reports a high rate of local control also in nongastric localizations, in which this therapeutic modality has been recommended by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. 118 Modern radiotherapy techniques, such as 3-dimensional conformal radiotherapy and intensity-modulated radiotherapy, allow an accurate determination of the clinical target volume, thus reducing toxicity to surrounding organs.…”

Section: Treatment Of Malt Lymphoma Patients With Advanced-stage Disementioning

confidence: 99%

The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance

Zucca

Bertoni

2016

Blood

234

205

View full text Add to dashboard Cite

Extranodal marginal zone (MZ) B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT) arise from lymphoid populations that are induced by chronic inflammation in extranodal sites. The best evidence of an etiopathogenetic link is provided by the association between Helicobacter pylori–positive gastritis and gastric MALT lymphoma. Indeed, successful eradication of this microorganism with antibiotics can be followed by gastric MALT lymphoma regression in most cases. Other microbial agents have been implicated in the pathogenesis of MZ lymphoma arising at different sites. Apart from gastric MALT lymphoma, antibiotic therapies have been adequately tested only in ocular adnexal MALT lymphomas where upfront doxycycline may be a reasonable and effective initial treatment of patients with Chlamydophila psittaci–positive lymphoma before considering more aggressive strategies. In all other instances, antibiotic treatment of nongastric lymphomas remains investigational. Indeed, there is no clear consensus for the treatment of patients with gastric MALT lymphoma requiring further treatment beyond H pylori eradication or with extensive disease. Both radiotherapy and systemic treatments with chemotherapy and anti-CD20 antibodies are efficacious and thus the experience of individual centers and each patient’s preferences in terms of adverse effects are important parameters in the decision process.

show abstract

“…Several retrospective studies have reported that radiotherapy has excellent clinical outcomes and minimal toxicities in patients with gastric MALT lymphoma [4–6]. …”

Section: Introductionmentioning

confidence: 99%

Radiotherapy for localized gastric mucosa–associated lymphoid tissue lymphoma: long-term outcomes over 10 years

Ohkubo

Saito

Ushijima

et al. 2017

Journal of Radiation Research

View full text Add to dashboard Cite

This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa–associated lymphoid tissue (MALT) lymphoma. Twenty-seven patients with Stage I gastric MALT lymphoma were treated with radiotherapy from 1999 to 2010. The median age was 65 years (range: 31–84). Fifteen patients were Helicobacter pylori–negative. Thirteen patients were treated with definitive radiotherapy alone. The other 14 patients who had refractory or residual disease following a prior treatment received salvage radiotherapy. The median dose of the radiotherapy was 30 Gy in 20 fractions (range: 30–39.5 Gy). The median follow-up period was 121 months (range: 8–176 months). The 5- and 10-year overall survival rates for all patients were 92% and 87%, respectively. No patients died from MALT lymphoma. Three patients died of other diseases at 8, 33 and 74 months after radiotherapy (myocardial infarction, pneumonia and hepatocellular carcinoma, respectively). No cases of local recurrence were observed during the follow-up period. There were no serious late gastric, liver or kidney complications during a median follow-up period of over 10 years. Two patients remain alive with distant metastases: a lung metastasis and an abdominal lymph node metastasis at 104 months and 21 months after radiotherapy, respectively. Excellent long-term local control was observed in patients with localized gastric MALT lymphoma after radiotherapy. However, lifelong follow-up should be conducted to detect cases of late recurrence, especially distant metastases.

show abstract

Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy: a retrospective, multi-centre, International Extranodal Lymphoma Study Group study

Cited by 77 publications

References 46 publications

Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance

Radiotherapy for localized gastric mucosa–associated lymphoid tissue lymphoma: long-term outcomes over 10 years

Contact Info

Product

Resources

About