Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy—The Austrian experience

Abstract

Despite the retrospective nature of the study and the inhomogeneous patient sample, we found good long-term effects of the KD on seizure frequency, EEG and neurological development.

Efficacy and tolerability of the ketogenic diet in Dravet syndrome – Comparison with various standard antiepileptic drug regimen

“…These results are similar to those reported from other centers and similar to our experiences with the KD in other epilepsy syndromes (Dressler et al, 2010;Kossoff et al, 2010;Maydell et al, 2001;Nabbout et al, 2010).…”

Can we predict efficacy of the ketogenic diet in children with refractory epilepsy?

“…This is 33% of all children with success on the diet after 1 year. These results are in line with previous studies [8,15,16]…”

“…West syndrome and in 50% of patients with Lennox-Gastaut-syndrome. [15] In our study at Sophia Children's Hospital these results are respectively 46% and 50%. No significant differences were found between the electroclinical syndromes with respect to efficacy, however numbers are very small.…”

“…This finding is in line with results of Dressler et al who found a succesful response after one year on KD in 62.5% of patients with Dravet syndrome. [15] M A N U S C R I P T…”

SCN2A mutation in a Chinese boy with infantile spasm - response to Modified Atkins Diet

“…The ketogenic diet was showed to improve the seizure thresholds in mice with SCN1A mutation which is the major cause of Dravet syndrome [14]. Previous studies demonstrated a significant reduction of seizure frequency in patients with Dravet syndrome who were maintained on this diet [15,16]. Recent evidence showed that the ketones produced after MAD could reduce synaptic transmission and neuron excitability by inhibiting glutamate transport and activation of ATP-sensitive potassium channels [17].…”