Long-Term Outcome and Prognosis Factors of Isolated Aortitis

Ferfar, Yasmina; Morinet, Sarah; Espitia, O.; Agard, C.; Vautier, Mathieu; Comarmond, C.; Desbois, Anne Claire; Domont, Fanny; Fouret, Pierre; Redheuil, Alban; Cluzel, Philippe; Chiche, Laurent; Koskas, Fabien; Resche‐Rigon, Matthieu; Cacoub, P.; Biard, Lucie; Saadoun, David

doi:10.1161/circulationaha.120.045957

Cited by 20 publications

(3 citation statements)

References 5 publications

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“…Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has a role in diagnosing aortitis, showing an increase in FGD uptake by inflammatory cells in the aorta [ 152 , 153 , 154 ]. Ferfar et al [ 155 ] followed up 353 patients with aortitis for 52 months and found that AADs occurred in 5%, 2%, and 10% of patients with GCA, TAK, and CIA, respectively. These data indicate that patients with aortitis are at risk for future aortic complications, particularly in those with CIA.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Thoracic Aortic Dissection

Zhou

Cecchi

Prakash

et al. 2022

Genes

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Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic dissection (AAD). These Stanford type A AADs, in which the tear occurs above the sinotubular junction, leading to the formation of a false lumen in the aortic wall that may extend to the arch and thoracoabdominal aorta. Type B AADs originate in the descending thoracic aorta just distal to the left subclavian artery. Genetic variants and various environmental conditions that disrupt the aortic wall integrity have been identified that increase the risk for thoracic aortic aneurysms and dissections (TAD). In this review, we discuss the predominant TAD-associated risk factors, focusing primarily on the non-genetic factors, and discuss the underlying mechanisms leading to TAD.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Thoracic Aortic Dissection

Zhou

Cecchi

Prakash

et al. 2022

Genes

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“…Although still debatable, systemic glucocorticoids are the mainstay therapy for patients with isolated aortitis, particularly to prevent the occurrence of aortic aneurysms and dissections in the future [93,[95][96][97][98]. Other immunosuppressants, such as methotrexate, azathioprine, cyclophosphamide, and tocilizumab, have also been successfully applied [93].…”

Section: Isolated Aortitismentioning

confidence: 99%

Localized Forms of Vasculitis

et al. 2021

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Purpose of Review To provide an updated review on epidemiology, clinical manifestations, diagnostic assessment, treatment, and prognosis of localized vasculitis, following the 2012 Revised International Chapel Hill Consensus Conference Nomenclature on single-organ vasculitis. Recent Findings Localized, single-organ vasculitides encompass a group of rare conditions in which there is no evidence of concomitant systemic vasculitis. Most data on this topic derives from case reports and small case series. Although some aspects of these diseases, such as clinical manifestations and histologic findings, have already been extensively investigated, there is still a lack of robust data concerning the pathogenesis, epidemiology, and treatment. Summary Localized vasculitides may have a wide range of clinical features depending on the organ affected. The inflammatory process may have a multifocal/diffuse or unifocal distribution. Diagnosis is usually based on histopathology findings and exclusion of systemic vasculitis, which may frequently pose a challenge. Further research on treatment is warranted. Keywords Single-organ vasculitis . Cutaneous leukocytoclastic angiitis . Cutaneous arteritis . Isolated aortitis This article is part of the Topical Collection on Vasculitis

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“…Rarely, aortitis may be a complication of rheumatic diseases such as ankylosing spondylitis or relapsing polychondritis (2). Aortitis is associated with significant morbidity and potential mortality related to aneurysmal dilatation, aortic dissection, or rupture (3)(4)(5)(6). Histological evidence of aortitis, considered to be the gold standard diagnostic method, is only available after aneurysm surgery.…”

Section: Introductionmentioning

confidence: 99%

Relationship between histopathological features of non-infectious aortitis and the results of pre-operative 18F-FDG-PET/CT: a retrospective study of 16 patients

Parreau

Espitia

Bold

et al. 2022

Clinical and Experimental Rheumatology

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ObjectiveTo describe the characteristics of 18 F-fluorodeoxyglucose positron-emission tomography/computed-tomography ( 18 FDG-PET/CT) findings before surgery in patients with active, histologically confirmed aortitis, and to correlate the degree of arterial wall inflammation with PETVAS score. MethodsThis was a multiple-centre retrospective study including cases with histologically proven active, non-infectious aortitis who had a 18 FDG-PET/CT performed within one year before surgery for aneurysm repair. PETVAS score was determined by radiologists blinded to the pathology findings. Cardiovascular pathologists reviewed aortic tissue samples and graded the degree of inflammation in the vessel wall. ResultsSixteen patients were included (8 giant cell arteritis, 4 clinically isolated aortitis, 2 Takayasu's arteritis, 1 relapsing polychondritis, and 1 rheumatoid arthritis). In 5/16 (31%) patients, 18 FDG-PET/CT did not detect the presence of aortic inflammation; two of whom were being treated with glucocorticoids at the time of procedure. Ascending thoracic and abdominal aorta had the highest FDG uptake among the affected territories. Patients without active aortitis on 18 FDG-PET/ CT were significantly older (p=0.027), had a lower PETVAS score (p=0.007), and had a lower degree of adventitial inflammation (p=0.035). In contrast, there was no difference between 18 FDG-PET/CT active and inactive aortitis patients as regards the timing between PET/CT and surgery, serum CRP level (during 18 FDG-PET/CT) and, FDG uptake per study site. ConclusionIn histologically proved aortitis, 18 FDG-PET/CT before surgery did not detect vascular inflammation in 31% patients, and PETVAS score correlated with the degree of adventitial histopathologic inflammation.

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Long-Term Outcome and Prognosis Factors of Isolated Aortitis

Cited by 20 publications

References 5 publications

Risk Factors for Thoracic Aortic Dissection

Risk Factors for Thoracic Aortic Dissection

Localized Forms of Vasculitis

Relationship between histopathological features of non-infectious aortitis and the results of pre-operative 18F-FDG-PET/CT: a retrospective study of 16 patients

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