Long-term outcome after surgical resection for cholangiocarcinoma and prognostic index value

Wang, Yue; Duan, Bo-Shi; Yan, Long; Shen, Chunjian; Luo, Ji; Shen, Feng; Zhao, Guohua

doi:10.1016/j.surge.2014.05.003

Cited by 4 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For cholangiocarcinoma, there are a few publications citing margin status as a prognostic factor on multivariate analysis . A systematic review of ICC did not include margin status among significant prognostic factors .…”

Section: Resultsmentioning

confidence: 99%

Data set for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2018

View full text Add to dashboard Cite

Optimal patient management benefits from comprehensive and accurate pathology reports that contribute to cancer staging and prognostication. Proforma reports are used in many countries, but these vary in their structure and implementation. The International Collaboration on Cancer Reporting (ICCR) is an alliance formed by the Royal College of Pathologists of Australasia, the Royal College of Pathologists of the United Kingdom, the College of American Pathologists, the Canadian Partnership Against Cancer the European Society of Pathology and the American Society of Clinical Pathology (ASCP), with the aim of developing an evidence-based reporting data set for each cancer site. It is argued that this should reduce the global burden of cancer data set development and reduplication of effort by different international institutions that commission, publish and maintain standardised cancer reporting data sets. The resultant standardisation of cancer reporting will benefit not only those countries directly involved in the collaboration but also others not in a position to develop their own data sets. We describe the development of a cancer data set by the ICCR expert panel for the reporting of the main malignant liver tumours: intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma and present the 'required' and 'recommended' elements to be included in the report with an explanatory commentary. This data set incorporates definitions and classifications in the most recent World Health Organisation (WHO) publication on hepatic malignancies (4th edition) and the recently published tumour-node-metastasis (TNM)8 staging system. Widespread adoption and implementation of this data set will enable consistent and accurate data collection, comparison of epidemiological and pathological parameters between different populations, facilitate research and ultimately result in better patient outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Data set for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In order to offer a better chance to receive a tailored treatment after resection and to improve the long term outcomes of these patients, the Chinese authors created a formula in which they introduced the number of lymph node metastases, the serum levels of CEA and the surgical margins, these three parameters being the most significant ones in multivariate analysis for survival (15). These parameters were quoted with 1 point if the resection margin was positive, if the lymph nodes presented metastases and if the serum level of CEA was higher than 15 ng/ml, and 2 points if the resection margin was negative, if the lymph nodes did not present metastatic disease and if the serum levels were lower than 15 ng/ml.…”

Section: The Impact Of Lymph Node Metastases After Resection With Curmentioning

confidence: 99%

“…These parameters were quoted with 1 point if the resection margin was positive, if the lymph nodes presented metastases and if the serum level of CEA was higher than 15 ng/ml, and 2 points if the resection margin was negative, if the lymph nodes did not present metastatic disease and if the serum levels were lower than 15 ng/ml. According to the value of this score, the 169 cases introduced in this study were classified in three categories -high risk, middle risk and low risk, the three categories reporting a significant difference in terms of survival (15).…”

Section: The Impact Of Lymph Node Metastases After Resection With Curmentioning

confidence: 99%

The influence of lymph node status on the overall survival in surgically treated hilar cholangiocarcinoma

Bacalbaşa¹,

Bălescu²,

Vîlcu³

et al. 2019

Ro J Med Pract.

View full text Add to dashboard Cite

Cholangiocarcinoma represents an extremely aggressive digestive malignancy associated with very poor survival rates in the absence of a treatment with curative intent. Moreover, an important per cent of patients are diagnosed in advanced stages of the disease, when resection with curative intent is no longer feasible. When it comes to cases which can be submitted to surgery, radical resection, including lymph node dissection, seems to be one of the most important therapeutic strategies in order to improve survival. This is a literature review of the most relevant studies which were focused on analyzing the impact of lymph node status on the overall survival of surgically treated hilar cholangiocarcinomas.

show abstract

“… 10 – 16 Margin status significantly affected survival, where a positive margin (R1 resection) remained a negative prognostic factor for ICC patients. 17 , 18 Moreover, several studies suggested a survival advantage for negative margins of 1.0 cm or more (wide margin) compared to negative margins of <1.0 cm (narrow margin). 19 – 21 …”

Section: Introductionmentioning

confidence: 99%

Benefit of adjuvant radiotherapy following narrow-margin hepatectomy in patients with intrahepatic cholangiocarcinoma that adhere to major vessels

Zheng¹,

Chen²,

Wu³

et al. 2018

CMAR

View full text Add to dashboard Cite

PurposeTo evaluate the role of adjuvant radiotherapy after narrow-margin (<1.0 cm) resection in patients with intrahepatic cholangiocarcinoma (ICC) adherent to major vessels.Patients and methodsThis retrospective study included 70 ICC patients. Forty-nine patients received narrow-margin (<1.0 cm) hepatectomy and 21 patients underwent wide-margin (≥1.0 cm) hepatectomy (Group C). Twenty-six of 49 were treated with postoperative radiotherapy (Group A), while the remaining 23 did not receive radiotherapy (Group B). Clinical outcomes were compared in the 3 groups. Toxicities of radiotherapy were evaluated.ResultsWith a median follow-up time of 42 months, the 3-year overall survival (OS) and disease-free survival rates were 55% and 44% for Group A, 20% and 10% for Group B, and 65% and 33% for Group C, respectively. The OS and disease-free survival in Groups A and C were comparable and improved compared to Group B (Group A vs B, P=0.011 and P=0.031; and Group C vs B, P=0.031 and P=0.105). Multivariate analysis showed that receiving narrow-margin resection only (adjusted hazard ratio: 3.73; 95% CI: 1.36–10.25; P=0.001) was a significant poor prognostic risk factor of OS. Group B experienced more intrahepatic recurrence and extrahepatic recurrence than Groups A and C. For Groups A and B, the 3-year intrahepatic recurrence rates were 36% vs 67% (P=0.133) and extrahepatic recurrence rates were 43% vs 65% (P=0.007). Only 2 patients in Group A suffered from grade 3 toxicities. No patient developed classic or nonclassic radiation-induced liver disease.ConclusionPostoperative radiotherapy following narrow-margin hepatectomy seems to be efficacious and well-tolerated in patients with ICC adjacent to major vessels.

show abstract

Long-term outcome after surgical resection for cholangiocarcinoma and prognostic index value

Cited by 4 publications

References 28 publications

Data set for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Data set for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

The influence of lymph node status on the overall survival in surgically treated hilar cholangiocarcinoma

Benefit of adjuvant radiotherapy following narrow-margin hepatectomy in patients with intrahepatic cholangiocarcinoma that adhere to major vessels

Contact Info

Product

Resources

About