“…These include both acute toxicities, such as mucositis, nausea, pain, hematologic changes, and stomatitis, among numerous other acute side effects, and late toxicities, such as chronic xerostomia, fibrosis, edema, trismus, and dysphagia [67]. Low risk HPV+ patients that are known to have significantly better survival rates would benefit from treatment de-intensification in order to minimize short and long-term treatment sequelae [72], while maintaining high rates of loco-regional control [73]. As such, a recent publication by our group described the need to refine the current recursive partitioning analysis (RPA) based TMN stage and prognostic groups for classification of HPV+ OPC, as defined by the AJCC/UICC classification system.…”