Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial

Seracchioli, Renato; Mabrouk, Mohamed; Frascà, Clarissa; Manuzzi, Lisa; Savelli, L.; Venturoli, Stefano

doi:10.1016/j.fertnstert.2009.03.083

Cited by 143 publications

(75 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Observational studies may be very helpful in assessing the real-world effectiveness of treatments that have already been demonstrated to work in highly controlled research settings [49], as OCs and NETA in women with symptomatic endometriosis [5, 7, 8, 12]. …”

Section: Discussionmentioning

confidence: 99%

Shifting from Oral Contraceptives to Norethisterone Acetate, or Vice Versa, because of Drug Intolerance: Does the Change Benefit Women with Endometriosis?

Vercellini

Ottolini

Frattaruolo

et al. 2018

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background/Aims: Oral contraceptives (OC) and norethisterone acetate (NETA) are among first-line medical therapies for symptomatic endometriosis, but their use is sometimes associated with intolerable side effects. We investigated whether shifting from low-dose OC to NETA (2.5 mg/day), or vice versa, improved tolerability. Methods: Sixty-seven women willing to discontinue their treatment because of intolerable side effects despite good pain relief, were enrolled in a self-controlled study, and shifted from OC to NETA (n = 35) or from NETA to OC (n = 32). The main study outcome was satisfaction with treatment 12 months after the change. Tolerability, pain symptoms, health-related quality of life, psychological status, and sexual functioning were also evaluated. Results: After treatment change, good tolerability was reported by 37% of participants who shifted to NETA, and by 52% of those who shifted to OC. At 12-month assessment, 51% of women intolerant to OC were satisfied with NETA, and 65% of those intolerant to NETA were satisfied with OC (intention-to-treat analysis). Other study variables did not vary substantially. Conclusions: In selected endometriosis patients, shifting from OC to NETA, or vice versa, because of side effects, improved tolerability. Better results were observed when substituting NETA with OC rather than the other way round.

show abstract

Section: Discussionmentioning

confidence: 99%

Shifting from Oral Contraceptives to Norethisterone Acetate, or Vice Versa, because of Drug Intolerance: Does the Change Benefit Women with Endometriosis?

Vercellini

Ottolini

Frattaruolo

et al. 2018

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Sesti et al [4] reported that postoperative continuous OC pills (ethinyl estradiol 0.03 mg and gestodene 0.075 mg daily) for 6 months were more effective than surgery plus placebo and were equally effective compared with surgery plus 6 months of a gonadotropin-releasing hormone agonist in reducing dysmenorrhea and nonmenstrual pain. In the study of Seracchioli et al [5], a significant reduction in dysmenorrhea was found in patients who underwent laparoscopic excision for symptomatic ovarian endometrioma and received postoperative continuous OC pills (ethinyl estradiol 0.02 mg and gestodene 0.075 mg daily) for 24 months versus those who received postsurgical cyclic OC pills and those who received no postoperative medical treatment. Our findings that 88.1% of our subjects were satisfied or very satisfied with their treatment confirm the efficacy and tolerability of 24 weeks of postoperative continuous OC pills.…”

Section: Discussionmentioning

confidence: 99%

“…In women with endometriosis-associated recurrent dysmenorrhea that does not respond to cyclic OC use, long-term reduction of pain and an appreciable degree of overall satisfaction with therapy can be obtained by continuous administration of a monophasic OC [3]. Postoperative continuous OC pills were demonstrated to be more effective than surgery plus placebo or surgery alone and were equally effective compared with surgery plus a gonadotropin-releasing hormone agonist in reducing endometriosis-associated pain [4,5]. …”

Section: Introductionmentioning

confidence: 99%

Postoperative Depot Medroxyprogesterone Acetate versus Continuous Oral Contraceptive Pills in the Treatment of Endometriosis-Associated Pain: A Randomized Comparative Trial

Cheewadhanaraks

Choksuchat

Dhanaworavibul

et al. 2012

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background/Aim: To evaluate the efficacy and tolerability of postoperative depot medroxyprogesterone acetate (DMPA) versus postoperative continuous oral contraceptive (OC) pills in the treatment of endometriosis-associated pain. Methods: After a conservative surgery, 84 patients with symptomatic endometriosis were randomized to receive either intramuscular DMPA (150 mg) every 12 weeks for 24 weeks or continuous OC pills (ethinyl estradiol 0.03 mg and gestodene 0.075 mg) daily for 24 weeks. At weeks 12 and 24 of the treatment phase, patients rated their satisfaction with treatment and reported pain improvement and adverse effects. Results: There was no significant difference in the percentages of patients who reported satisfaction between the DMPA group and the OC group at weeks 12 and 24 (92.9 vs. 90.5%, and 92.9 vs. 88.1%, respectively). The rates of withdrawal because of persistent pain or side effects in the two groups were similar. Pain scores improved significantly in both groups, but dysmenorrhea scores on a visual analog scale at week 24 were significantly higher in the OC group than in the DMPA group (p = 0.039). Conclusion: Both postoperative DMPA and postoperative OC pills for 24 weeks were found to be effective and acceptable options for treating endometriosis-associated pain.

show abstract

“…The combined pill and oral progestogens have been found to reduce the frequency and severity of recurrent endometriosis-related dysmenorrhoea 17 and endometriomas after surgery. 18 Local pelvic release of levonorgestrel via an intrauterine system is an effective way of delivering progestogen therapy and has been found to be as effective at relieving dysmenorrhoea as gonadotropin releasing hormone agonists 19 or injectable progestogens, without the same degree of systemic symptoms.…”

Section: Secondary Preventionmentioning

confidence: 99%

Medical management of endometriosis

Black¹,

Fraser²

2012

Aust Prescr

View full text Add to dashboard Cite

Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial

Cited by 143 publications

References 20 publications

Shifting from Oral Contraceptives to Norethisterone Acetate, or Vice Versa, because of Drug Intolerance: Does the Change Benefit Women with Endometriosis?

Shifting from Oral Contraceptives to Norethisterone Acetate, or Vice Versa, because of Drug Intolerance: Does the Change Benefit Women with Endometriosis?

Postoperative Depot Medroxyprogesterone Acetate versus Continuous Oral Contraceptive Pills in the Treatment of Endometriosis-Associated Pain: A Randomized Comparative Trial

Medical management of endometriosis

Contact Info

Product

Resources

About