2020
DOI: 10.1016/j.reth.2020.04.010
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Long-term observation of airway reconstruction using decellularized tracheal allografts in micro-miniature pigs at growing stage

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Cited by 7 publications
(5 citation statements)
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“…It has been confirmed that a natural decellularized tracheal extracellular matrix (dtECM) that meets the above requirements can be effectively obtained using decellularization 20,35,36 . It has been demonstrated that dtECM supports neo‐epithelialization, endothelialization, and chondrocyte viability, 40 and it may serve as a promising biomaterial for tracheal reconstitution 41 . Although natural dtECM meets the requirements of most idealized tracheal grafts, the critical limitation is that the biomechanical properties of the scaffold are considerably reduced, resulting in serious complications, such as the softening and stenosis of the grafts in the early stage after orthotopic transplantation 14,42 .…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…It has been confirmed that a natural decellularized tracheal extracellular matrix (dtECM) that meets the above requirements can be effectively obtained using decellularization 20,35,36 . It has been demonstrated that dtECM supports neo‐epithelialization, endothelialization, and chondrocyte viability, 40 and it may serve as a promising biomaterial for tracheal reconstitution 41 . Although natural dtECM meets the requirements of most idealized tracheal grafts, the critical limitation is that the biomechanical properties of the scaffold are considerably reduced, resulting in serious complications, such as the softening and stenosis of the grafts in the early stage after orthotopic transplantation 14,42 .…”
Section: Discussionmentioning
confidence: 89%
“… 20 , 35 , 36 It has been demonstrated that dtECM supports neo‐epithelialization, endothelialization, and chondrocyte viability, 40 and it may serve as a promising biomaterial for tracheal reconstitution. 41 Although natural dtECM meets the requirements of most idealized tracheal grafts, the critical limitation is that the biomechanical properties of the scaffold are considerably reduced, resulting in serious complications, such as the softening and stenosis of the grafts in the early stage after orthotopic transplantation. 14 , 42 Pure synthetic tracheal grafts have favorable biomechanical properties; however, they exhibit numerous graft‐related complications, including obstructive granulation tissue and anastomotic leaks, lack of vascularization, epithelial lining, or fusion into surrounding tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Porcine trachea was obtained from Tokyo Shibaura Zoki KK (Tokyo, Japan) and decellularized using HHP, as reported previously [ 25 , 26 ]. Tracheal tissues were cut into 2 × 2 cm 2 and packed in plastic bags with 1% penicillin-streptomycin (100 U/mL penicillin and 100 μg/mL streptomycin; Sigma-Aldrich, St. Louis, MO) saline solution, sealed using a heat sealer.…”
Section: Methodsmentioning
confidence: 99%
“…A suitable tracheal substitute is required for successful airway reconstruction. Many ways to develop acceptable tracheal substitutes have been tested in clinical practice over the years, including autologous tracheal transplantation [ 9 , 10 , 11 ], tracheal allotransplantation [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ], and stent implantation [ 19 ], as shown in Figure 1 . Autologous transplantation is regarded as a tracheal transplantation procedure that causes the least amount of immune rejection and can prevent some potential issues, like infection and cracking [ 20 ].…”
Section: Introductionmentioning
confidence: 99%