“…With a prevalence between 40% and 63.5%, congenital heart defects (CHD) are the primary cause of morbidity and mortality among DS patients. 1,12 Atrioventricular septal defects and ventricular septal defects are the two most common, making up 45% and 35% of all CHDs in this population, respectively. 13 The prevalence of isolated atrial septal defects, persistent ductus arteriosus, and tetralogy of Fallot are 8%, 7%, and 4%, respectively.…”