Long-term neurologic outcome of hemilaminectomy and disk fenestration for treatment of dogs with thoracolumbar intervertebral disk herniation: 831 cases (2000–2007)

Aikawa, Takeshi; Fujita, Hiroshi; Kanazono, Shinichi; Shibata, Mitsuhiro; Yoshigae, Yuki

doi:10.2460/javma.241.12.1617

Cited by 110 publications

(192 citation statements)

References 43 publications

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“…For long‐term functional recovery, presence of DPP in nonambulatory dogs with thoracolumbar IVDH is associated with positive outcomes in nearly 100% of the cases;2, 39, 48 however, absence of DPP has been correlated with a recovery rate of approximately 50% 2, 6, 25, 39. A clear difference is detected in the current study with lower accuracy of DPP to predict early MFR in comparison with formerly reported prediction of long‐term MFR.…”

Section: Discussioncontrasting

confidence: 79%

“…Chondrodystrophic breeds such as Dachshunds are frequently affected by early degeneration of intervertebral disks and presence of intercapital ligaments may partially prevent intervertebral disks to herniate in cranial segments of the thoracic vertebral column 2, 3, 4, 5, 23, 42, 44, 45…”

Section: Discussionmentioning

confidence: 99%

“…A clear difference is detected in the current study with lower accuracy of DPP to predict early MFR in comparison with formerly reported prediction of long‐term MFR. Late‐onset recovery of ambulation in paraplegic dogs with IVDH after surgical decompression can appear up to 6 months thereafter and ranges from 13.4% to 31.8% of which some dogs regain ambulation without regaining DPP 2. However, for early application of novel treatment strategies in dogs which would fail standard therapy, prediction of early MFR becomes useful and necessary allowing selection of target populations.…”

Section: Discussionmentioning

confidence: 99%

“…Presence of DPP was defined as an obvious and reproducible behavioral response that could be interpreted as pain toward a noxious stimulus (ie, whining, sudden turning the head, and/or biting attempts toward the source of stimulus). For the test, digits of both hindlimbs were clamped using forceps 2, 25, 39…”

Section: Methodsmentioning

confidence: 99%

“…Evaluation of DPP and length of intramedullary hyperintense signal in sagittal T2‐weighted MRI were proven to be useful predictive tools for long‐term MFR 2, 18, 21, 23…”

mentioning

confidence: 99%

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Comparison of Preoperative Quantitative Magnetic Resonance Imaging and Clinical Assessment of Deep Pain Perception as Prognostic Tools for Early Recovery of Motor Function in Paraplegic Dogs with Intervertebral Disk Herniations

Wang‐Leandro

Siedenburg

Hobert

et al. 2017

Veterinary Internal Medicne

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BackgroundPrognostic tools to predict early postoperative motor function recovery (MFR) after thoracolumbar intervertebral disk herniation (IVDH) in paraplegic dogs represent an opportunity to timely implement novel therapies that could shorten recovery times and diminish permanent neurological dysfunctions.HypothesisFractional anisotropy (FA) values obtained using diffusion tensor imaging have a higher prognostic value than a lesion extension ratio in T2‐weighted images (T2W‐LER) and clinical assessment of deep pain perception (DPP) for MFR.AnimalsThirty‐five paraplegic dogs with diagnosis of acute or subacute thoracolumbar IVDH.MethodsProspective, descriptive observational study. At admission, absence or presence of DPP, T2W‐LER, and FA values was evaluated. MFR was assessed within 4 weeks after decompressive surgery. Values of T2W‐LER and FA of dogs with and without MFR were compared using t‐tests. All 3 methods were evaluated for their sensitivity and specificity as a prognostic factor.ResultsNo differences were found between groups regarding T2W‐LER. FA values differed statistically when measured caudally of lesion epicenter being higher in dogs without MFR compared to dogs with MFR (P = .023). Logistic regression analysis revealed significance in FA values measured caudally of the lesion epicenter (P = .033, area under the curve = 0.72). Using a cutoff value of FA = 0.660, the technique had a sensitivity of 80% and a specificity of 55%. Evaluation of DPP had a sensitivity of 73.3% and specificity of 75% (P = .007).Conclusions and Clinical ImportanceEvaluation of DPP showed a similar sensitivity and a better specificity predicting early MFR than quantitative magnetic resonance imaging.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Evaluation of DPP and length of intramedullary hyperintense signal in sagittal T2‐weighted MRI were proven to be useful predictive tools for long‐term MFR 2, 18, 21, 23…”

mentioning

confidence: 99%

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Comparison of Preoperative Quantitative Magnetic Resonance Imaging and Clinical Assessment of Deep Pain Perception as Prognostic Tools for Early Recovery of Motor Function in Paraplegic Dogs with Intervertebral Disk Herniations

Wang‐Leandro

Siedenburg

Hobert

et al. 2017

Veterinary Internal Medicne

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Incidence and clinical characterisation of thoracolumbar intervertebral disc extrusions in Basset Hounds compared with Dachshunds

Thatcher,

Targett,

Alcoverro

et al. 2023

Veterinary Record

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BackgroundThe Basset Hound is the largest chondrodystrophic breed predisposed to thoracolumbar intervertebral disc extrusion (TL‐IVDE). However, literature describing this particular breed in terms of incidence, signalment, anatomical location, clinical severity and short‐term outcome of TL‐IVDE is lacking.MethodsThe medical histories of Dachshunds and Basset Hounds presenting to three neurology departments were retrospectively assessed. Information collected for each dog included signalment, whether it had received a diagnosis of TL‐IVDE, duration of clinical signs, affected discs and anatomical region and neurological grading at presentation and discharge.ResultsA total of 270 Dachshunds and 188 Basset Hounds were included for incidence analysis. Of these, 154 Dachshunds and 68 Basset Hounds with confirmed TL‐IVDE were included for signalment, anatomical location, clinical severity and short‐term outcome analysis. Statistical analysis indicated a significantly higher incidence of TL‐IVDE in Dachshunds than in Basset Hounds (77.4% vs. 36.2%, p < 0.05). Basset Hounds presenting to a neurology department were older (median 87.5 months vs. 66.5 months), had a greater proportion of midlumbar IVDE (L2–L5) and were more frequently ambulatory at discharge than Dachshunds. Only one Basset Hound presented as paraplegic without nociception, compared with 16 Dachshunds (1.5% vs. 10.4%).LimitationsThe study had a retrospective design and included multicentric non‐standardised cases.ConclusionTL‐IVDE incidence was higher in Dachshunds than in Basset Hounds. Basset Hounds were older at presentation, frequently affected more caudally in the vertebral column and more frequently ambulatory at discharge than Dachshunds. The differences found in this study could aid in the development of preventive strategies.

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HASTE MRI sequence findings correlate with loss of deep pain perception in dogs with thoracolumbar disc extrusion

Khan

Freeman

2022

Veterinary Medicine & Sci

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Background Thoracolumbar intervertebral disc extrusion (TL IVDE) is a common reason for the veterinary hospital admission. Various imaging factors including degree and length of compression have been tested for correlation with clinical severity, but no reliable correlation has been found. Half‐Fourier acquisition single‐shot turbo spin echo (HASTE) magnetic resonance imaging (MRI) sequences highlight the dorsal and ventral cerebrospinal fluid (CSF) columns and have been used to demonstrate spinal cord swelling in dogs with TL IVDE. This has been used as a predictor of progressive ascending‐descending myelomalacia but has not been correlated with neurological grade. Objective This study aims to investigate the correlation between the attenuation of CSF HASTE signal and clinical severity in dogs suffering from TL disc extrusions. Methods Dogs less than 15 kg who were non‐ambulatory due to suspected TL IVDE were prospectively recruited for a study into conservative management. MRI studies were undertaken under sedation including HASTE sequences. The ratio of the length of CSF attenuation to the length of the L2 vertebra was calculated and correlated with clinical severity. Results Twenty dogs met the inclusion criteria. No statistically significant difference was demonstrated between the mean CSF attenuation and neurological grade (p = 0.17 but there was a significant difference in the mean CSF attenuation in those who retained deep pain perception and those who did not (p = 0.02). Time to loss of ambulation was also found to not be correlated with CSF attenuation (p = 0.95). Conclusion In conclusion, the length of CSF attenuation of HASTE MRI sequences in dogs less than 15 kg suffering from IVDEs may be correlated with a loss of deep pain perception.

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Long-term neurologic outcome of hemilaminectomy and disk fenestration for treatment of dogs with thoracolumbar intervertebral disk herniation: 831 cases (2000–2007)

Abstract: Prognosis for dogs with thoracolumbar IVDH that retain deep nociception in at least 1 of the pelvic limbs or tail before surgery was good.

Cited by 110 publications

References 43 publications

Comparison of Preoperative Quantitative Magnetic Resonance Imaging and Clinical Assessment of Deep Pain Perception as Prognostic Tools for Early Recovery of Motor Function in Paraplegic Dogs with Intervertebral Disk Herniations

Comparison of Preoperative Quantitative Magnetic Resonance Imaging and Clinical Assessment of Deep Pain Perception as Prognostic Tools for Early Recovery of Motor Function in Paraplegic Dogs with Intervertebral Disk Herniations

Incidence and clinical characterisation of thoracolumbar intervertebral disc extrusions in Basset Hounds compared with Dachshunds

HASTE MRI sequence findings correlate with loss of deep pain perception in dogs with thoracolumbar disc extrusion

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