Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: A report from the Pediatric Oncology Group

Managing Paraneoplastic Neurological Disorders

“…Ig, but residual central nervous system signs are frequent [59,63,73]. Treatment of the tumor with chemotherapy is the most important predictor of good neurological recovery [74].…”

Emergencies Caused by Pheochromocytoma, Neuroblastoma, or Ganglioneuroma

“…These paraneoplastic manifestations have an immunologic basis and are associated with IgG and IgM antibodies that bind to the cytoplasm of cerebellar Purkinje's cells and to some axons of the peripheral nerves [157]. In one patient with occult neuroblastoma, encephalitis-like features of ataxia, generalized seizures, decreased consciousness, and involuntary movements were seen; however, this patient did not have any signs of opsoclonus-myoclonus at any time during his illness [158].…”

Emergency Department Presentation of a Rare Neurological Disorder

“…Although autopsy has been inconclusive in the localization of the specific area affected by this syndrome, autoimmune destruction of Purkinje cells, dentate demyelination, and damage to the cerebellum and brainstem have all been implicated in the pathophysiology of OMS (6). Finally, a retrospective chart review of children conducted by Russo et al aimed at addressing the long-term neurological outcome of patients who develop OMS found that 18 of 29 (62%) experienced a complete recovery, as was seen in our patient (7).…”