Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children

Tsai, Meng‐Li; Hung, Kun Long; Tsan, Ying Ying; Tung, William Tao Hsin

doi:10.1016/j.yebeh.2015.04.067

Cited by 24 publications

(18 citation statements)

References 34 publications

(42 reference statements)

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“…Microcephaly, congenital heart malformation, and hearing impairment did not seem to affect IQ and the indexes for our cohort. In addition, mean FSIQ did not differ between KS patients with or without seizures, unlike the results from Tsai et al in 2015 …”

Section: Discussioncontrasting

confidence: 64%

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Molecular, clinical and neuropsychological study in 31 patients with Kabuki syndrome and KMT2D mutations

et al. 2017

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Kabuki syndrome (KS-OMIM 147920) is a rare developmental disease characterized by the association of multiple congenital anomalies and intellectual disability. This study aimed to investigate intellectual performance in children with KS and link the performance to several clinical features and molecular data. We recruited 31 children with KMT2D mutations who were 6 to 16 years old. They all completed the Weschler Intelligence Scale for Children, fourth edition. We calculated all indexes: the Full Scale Intellectual Quotient (FSIQ), Verbal Comprehension Index (VCI), Perceptive Reasoning Index (PRI), Processing Speed Index (PSI), and Working Memory Index (WMI). In addition, molecular data and several clinical symptoms were studied. FSIQ and VCI scores were 10 points lower for patients with a truncating mutation than other types of mutations. In addition, scores for FSIQ, VCI and PRI were lower for children with visual impairment than normal vision. We also identified a discrepancy in indexes characterized by high WMI and VCI and low PRI and PSI. We emphasize the importance of early identification and intensive care of visual disorders in patients with KS and recommend individual assessment of intellectual profile.

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Section: Discussioncontrasting

confidence: 64%

“…Mean VCI and WMI scores were significantly higher for HIP KS patients than KS patients with homogenous FSIQ scores (81 [17] vs 93 [12] and 64 [13] vs 61 [10], P < .05 and P < .001, respectively.…”

Section: Heterogeneous Intellectual Profile In Ks Patients With Kmtmentioning

confidence: 89%

Molecular, clinical and neuropsychological study in 31 patients with Kabuki syndrome and KMT2D mutations

et al. 2017

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“…Febrile seizures can affect neurocognitive function, particularly when seizures are complex (focal, repetitive, or prolonged). In fact, poor neurocognitive outcomes are often reported more than behavioral/emotional problems after febrile seizures . In a recent long‐term follow‐up study in China, complex febrile seizures were associated with impairment in cognitive function, but not behavioral and emotional problems .…”

Section: Neurocognitive Outcomes Of Acute Symptomatic Seizures and Fementioning

confidence: 99%

Prevalence, causes, and behavioral and emotional comorbidities of acute symptomatic seizures in Africa: A critical review

et al. 2017

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SummarySeizures with fever includes both febrile seizures (due to nonneurological febrile infections) and acute symptomatic seizures (due to neurological febrile infections). The cumulative incidence (lifetime prevalence) of febrile seizures in children aged ≤6 years is 2–5% in American and European studies, but there are no community‐based data on acute symptomatic seizures in Africa. The incidence of acute symptomatic seizures in sub‐Saharan Africa is more than twice that in high‐income countries. However, most studies of acute symptomatic seizures from Africa are based on hospital samples or do not conduct surveys in demographic surveillance systems, which underestimates the burden. It is difficult to differentiate between febrile seizures and acute symptomatic seizures in Africa, especially in malaria‐endemic areas where malaria parasites can sequester in the brain microvasculature; but this challenge can be addressed by robust identification of underlying causes. The proportion of complex acute symptomatic seizures (i.e., seizures that are focal, repetitive, or prolonged) in Africa are twice that reported in other parts of the world (>60% vs. ∼30%), which is often attributed to falciparum malaria. These complex phenotypes of acute symptomatic seizures can be associated with behavioral and emotional problems in high‐income countries, and outcomes may be even worse in Africa. One Kenyan study reported behavioral and emotional problems in approximately 10% of children admitted with acute symptomatic seizures, but it is not clear whether the behavioral and emotional problems were due to the seizures, shared genetic susceptibility, etiology, or underlying neurological damage. The underlying neurological damage in acute symptomatic seizures can lead not only to behavioral and emotional problems but also to neurocognitive impairment and epilepsy. Electroencephalography may have a prognostic role in African children with acute symptomatic seizures. There are significant knowledge gaps regarding acute symptomatic seizures in Africa, which results in lack of reliable estimates for planning interventions. Future epidemiological studies of acute symptomatic seizures should be set up in Africa.

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“…Aetiology is the major determinant of outcome . However, even children with no apparent pre‐existing neurological problems at CSE show evidence of short‐term structural and functional consequences after CSE …”

mentioning

confidence: 99%

Long‐term behavioural outcomes after paediatric convulsive status epilepticus: a population‐based cohort study

Martinos

Pujar

Gillberg

et al. 2017

Develop Med Child Neuro

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AimTo describe behavioural and psychiatric outcomes of children within 10 years of convulsive status epilepticus (CSE).MethodChildren originally identified by the population‐based North London Convulsive Status Epilepticus in Childhood Surveillance Study were followed‐up between July 2009 and February 2013. They were grouped into epilepsy‐ and non‐epilepsy‐related CSE, and compared with population norms and healthy controls using the Strengths and Difficulties Questionnaire; the Autism Spectrum Screening Questionnaire; and the Swanson, Nolan, and Pelham questionnaire. Children who scored above recommended clinical cut‐offs on any scale were invited for a neuropsychiatric assessment. Regression models were fitted to identify clinically relevant covariates associated with behavioural outcomes.ResultsAt a mean follow‐up of 8.1 years post‐CSE, 28% of enrolled children were found to have a psychiatric disorder. Children with epilepsy‐related CSE scored higher than norms on all scales and children with non‐epilepsy‐related CSE scored higher than norms on the Strengths and Difficulties Questionnaire and the Autism Spectrum Screening Questionnaire. Presence of seizures at baseline and recurrence of CSE was associated with worse outcomes in the group with epilepsy. Intellectual abilities were associated with behavioural outcomes in all participants.InterpretationA large proportion of children manifest behavioural issues 8 years after CSE. The present data highlight the need for behavioural screening in children with neurodevelopmental impairments post‐CSE.What this paper adds Eight years post convulsive status epilepticus (CSE), 37% of parents report behavioural issues.Of enrolled children, 28% were found to have a Diagnostic and Statistical Manual mental disorder.Intellectual abilities are strongly associated with behavioural outcomes in children post‐CSE.

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Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children

Cited by 24 publications

References 34 publications

Molecular, clinical and neuropsychological study in 31 patients with Kabuki syndrome and KMT2D mutations

Molecular, clinical and neuropsychological study in 31 patients with Kabuki syndrome and KMT2D mutations

Prevalence, causes, and behavioral and emotional comorbidities of acute symptomatic seizures in Africa: A critical review

Long‐term behavioural outcomes after paediatric convulsive status epilepticus: a population‐based cohort study

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