Long-Term Multilineage Development from Human Umbilical Cord Blood Stem Cells in a Novel SCID-HU Graft

Fraser, Christopher C.; Kaneshima, Hideto; Hansteen, Gun; Kilpatrick, Madison; Hoffman, Ronald; Chen, Benjamin P.

doi:10.1007/978-1-4613-0391-6_3

Cited by 1 publication

(2 citation statements)

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“…Fraser et al . [113], transplanted SCID‐human mice with CD34 + Thy‐1 + Lin – cells derived from human UCB and observed reconstitution of human hematopoiesis. Thus, these studies demonstrate that the human UCB cell capable of reconstituting long‐term hematopoiesis into SCID mice is comprised within the CD34 + Thy‐1 + Lin – cell subpopulation.…”

Section: In Vivo Characterization Of Ucb Hspcmentioning

confidence: 99%

“…Thus, these studies demonstrate that the human UCB cell capable of reconstituting long‐term hematopoiesis into SCID mice is comprised within the CD34 + Thy‐1 + Lin – cell subpopulation. It is noteworthy that, in both studies, the authors observed repopulation of secondary recipients by BM cells from primary recipients, demonstrating maintenance of an extensive proliferation capacity of the input human progenitor cell population [112, 113].…”

Section: In Vivo Characterization Of Ucb Hspcmentioning

confidence: 99%

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Biology of Human Umbilical Cord Blood‐Derived Hematopoietic Stem/Progenitor Cells

Mayani¹,

Lansdorp

1998

STEM CELLS

213

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Reported in 1989, studies by Broxmeyer, Gluckman, and colleagues demonstrated that umbilical cord blood (UCB) is a rich source of hematopoietic stem/progenitor cells (HSPC) and that UCB could be used in clinical settings for hematopoietic cell transplantation. Since then, a great interest has been generated on the biological characterization of these cells. Over the last nine years, several groups have focused on the study of UCB HSPC, addressing different aspects, such as the frequency of these cells in UCB, the identification of different HSPC subsets based on their immunophenotype, their ability to respond to hematopoietic cytokines, the factors that control their proliferation and expansion potentials, and their capacity to reconstitute hematopoiesis in animal models. Most of these studies have shown that significant functional differences exist between HSPC from UCB and adult bone marrow (i.e., the former possess higher proliferation and expansion potential than the latter). It is also noteworthy that genetic manipulation of UCB HSPC has been achieved by several groups and that genetically modified UCB cells have already been used in the clinic. In spite of the significant advances in the characterization of these cells, we are still in the process of trying to fully understand their biology, both at the cellular and the molecular levels. In the present article, we describe and discuss what is currently known about the biology of UCB HSPC. Stem Cells 1998;16:153-165 STEM CELLS 1998;16:153-165

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Section: In Vivo Characterization Of Ucb Hspcmentioning

confidence: 99%

Section: In Vivo Characterization Of Ucb Hspcmentioning

confidence: 99%