Long-Term Mortality and Hospital Readmission After Acute Myocardial Infarction: an Eight-Year Follow-Up Study

Andrés, Eva; Cordero, Alberto; Magán, Purificación; Alegría, Eduardo; León, Montserrat; Luengo, Emilio; Botaya, Rosa Magallón; Ortiz, Luis García; Casasnovas, José A.

doi:10.1016/j.rec.2011.09.012

Cited by 37 publications

(24 citation statements)

References 30 publications

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“…There are several explanations for this apparent paradox: the time elapsed since diagnosis of diabetes is less clearly related with the macrovascular risk (ACS in the present study) than with the microvascular complications [20] Although the prognosis for acute myocardial infarction is known to be worse in patients with diabetes, these patients tend to be mature adults [10]. The pathophysiological substrate in the endothelium may be different in young patients, in whom prethrombotic status and instability of the incipient plaques are predominant features attributable to smoking, as opposed to the diffuse lesions that typify long-term diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study in Spain found that people younger than 45 years of age accounted for 6% of all hospital admissions among men and 2% among women, but that the rates of hospital readmission were significantly higher than in the population in which the first event occurred at later ages [10]. Patients who have ACS at an early age are at risk for many potential years of life lost, and their post-event survival translates as substantial costs in terms of health and social resources consumed [11].…”

Section: Introductionmentioning

confidence: 99%

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Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis

Esteban¹,

Montero²,

Sánchez³

et al. 2014

TOCMJ

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Background:To describe the characteristics of patients ≤40 years of age hospitalized for acute coronary syndrome, analyze the risk factors and identify the variables associated with prognosis.Methods:Case series of patients admitted between 2003 and 2012 inclusive in a tertiary hospital (123 consecutive cases admitted between 2003 and 2012), and case-control study (369 controls selected from the general population matched for sex and age with cases, at a ratio of 3:1). Outcome variables: Mortality, likelihood of survival without readmission for heart-related problems, extent of coronary disease as determined by coronary angiography and cardiovascular risk factors. Results: Mean age was 35.4±4.8 years and 83.7% of the participants were men. Myocardial infarction with abnormal Q wave (48%) and single-vessel involvement (44.7%) predominated. Intrahospital mortality was 1.6%. For the 108 patients eventually included in the follow-up, likelihood of readmission-free survival after 60 months was 69.3±4.8%. In the case group 36% of the patients admitted to using cocaine. Compared to controls, the prevalence in patients was higher for smoking (74.8 vs 33.1%, p<0001), diabetes (14.6% vs 5.1%, p=0.001), low HDL-cholesterol (82.9 vs 34.1%, p<0.001) and obesity (30.0 vs 20.3%, p=0.029). Decreased left ventricular ejection fraction (odds ratio=2.2, p=0.033) and smoking (odds ratio=7.8, p=0.045) were associated with readmission for coronary syndrome.Conclusion: Acute coronary syndrome in people younger than 40 years is associated with diabetes and unhealthy lifestyle: smoking, sedentary behavior (low HDL-cholesterol), cocaine use and obesity. The readmission rate is high, and readmission is associated with smoking and decreased ejection fraction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis

Esteban¹,

Montero²,

Sánchez³

et al. 2014

TOCMJ

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“…In our model, we differentiated between the first year after diagnosis and the follow-up years. Patients may experience an improved quality of life in the follow-up years but they risk a relapse, which we took into account when calculating the health state utilities [60][61][62][63].…”

Section: Utilitiesmentioning

confidence: 99%

Methodology of the health economic evaluation of the Feel4Diabetes-study

et al. 2020

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Background: The clinical and economic burden of type 2 diabetes mellitus on society is rising. Effective and efficient preventive measures may stop the increasing prevalence, given that type 2 diabetes mellitus is mainly a lifestyle-driven disease. The Feel4Diabetes-study aimed to tackle unhealthy lifestyle (unhealthy diet, lack of physical activity, sedentary behaviour, and excess weight) of families with a child in the first grades of elementary school. These schools were located in regions with a relatively low socioeconomic status in Belgium, Bulgaria, Finland, Greece, Hungary and Spain. Special attention was paid to families with a high risk of developing type 2 diabetes mellitus. Methods: The aim of this paper is to describe the detailed methodology of the intervention's cost-effectiveness analysis. Based on the health economic evaluation of the Toybox-study, both a decision analytic part and a Markov model have been designed to assess the long-term (time horizon of 70 year with one-year cycles) intervention's value for money. Data sources used for the calculation of health state incidences, transition probabilities between health states, health state costs, and health state utilities are listed. Intervention-related costs were collected by questionnaires and diaries, and attributed to either all families or high risk families only. Conclusions: The optimal use of limited resources is pivotal. The future results of the health economic evaluation of the Feel4Diabetes-study will contribute to the efficient use of those resources.

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“…Diabetes mellitus is a risk factor with an increasing incidence and a negative prognosis for patients who undergo PCI 12. These patients benefit from particular treatment strategies13 that are generally more aggressive.…”

Section: Introductionmentioning

confidence: 99%

Remote ischaemic postconditioning: does it protect against ischaemic damage in percutaneous coronary revascularisation? Randomised placebo-controlled clinical trial

Carrasco-Chinchilla

Muñoz-García

Domínguez-Franco

et al. 2013

Heart

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Long-Term Mortality and Hospital Readmission After Acute Myocardial Infarction: an Eight-Year Follow-Up Study

Cited by 37 publications

References 30 publications

Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis

Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis

Methodology of the health economic evaluation of the Feel4Diabetes-study

Remote ischaemic postconditioning: does it protect against ischaemic damage in percutaneous coronary revascularisation? Randomised placebo-controlled clinical trial

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