Long-Term Microgravity Exposure Increases ECG Repolarization Instability Manifested by Low-Frequency Oscillations of T-Wave Vector

Palacios, Saúl; Caiani, Enrico Gianluca; Landreani, Federica; Martínez, Juan Pablo; Pueyo, Esther

doi:10.3389/fphys.2019.01510

Cited by 9 publications

(19 citation statements)

References 65 publications

(96 reference statements)

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“…Along with neuromuscular deconditioning [ 109 ], the skeletal involution is the most significant alteration that arises after prolonged habitation in space, mainly deriving from the lack of both mechanical forces and sun exposure. Weightless-related conditions also affect gas exchanges and cause cardiovascular derangements, both being linked to fluid accumulation and irregular perfusion [ 20 , 110 ].…”

Section: Resultsmentioning

confidence: 99%

“…Summary III. A total of 30 references ([ 17 , 18 , 20 , 24 , 87 , 90 , 91 , 92 , 93 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 ]) were used to scope the following nutritional commonalities between hospital vs. deep space hazards/illnesses. The interest in protecting the musculoskeletal system from reduced mechanical forces that expose the individual to an increased risk of fractures; the environmental consequences on the cardiovascular system; the relevance of stressful situations in causing metabolic and neurobehavioral disturbances; the potential consequences of prolonged periods of solitude.…”

Section: Resultsmentioning

confidence: 99%

“… Proteins Musculoskeletal health [ 84 ] Microgravity and radiation, musculoskeletal health, iron status. Iron Space hazards [ 20 , 110 ] Astronaut’s health, performance, and cardiac function. Fluid shifts Cardiovascular health [ 95 ] The role of the constant and pervasive force of gravity.…”

Section: Figure A1mentioning

confidence: 99%

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Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Briguglio

2021

Nutrients

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Since the Moon landing, nutritional research has been charged with the task of guaranteeing human health in space. In addition, nutrition applied to Orthopedics has developed in recent years, driven by the need to improve the efficiency of the treatment path by enhancing the recovery after surgery. As a result, nutritional sciences have specialized into two distinct fields of research: Nutritional Orthopedics and Space Nutrition. The former primarily deals with the nutritional requirements of old patients in hospitals, whereas the latter focuses on the varied food challenges of space travelers heading to deep space. Although they may seem disconnected, they both investigate similar nutritional issues. This scoping review shows what these two disciplines have in common, highlighting the mutual features between (1) pre-operative vs. pre-launch nutritional programs, (2) hospital-based vs. space station nutritional issues, and (3) post-discharge vs. deep space nutritional resilience. PubMed and Google Scholar were used to collect documents published from 1950 to 2020, from which 44 references were selected on Nutritional Orthopedics and 44 on Space Nutrition. Both the orthopedic patient and the astronaut were found to suffer from food insecurity, malnutrition, musculoskeletal involution, flavor/pleasure issues, fluid shifts, metabolic stresses, and isolation/confinement. Both fields of research aid the planning of demand-driven food systems and advanced nutritional approaches, like tailored diets with nutrients of interest (e.g., vitamin D and calcium). The nutritional features of orthopedic patients on Earth and of astronauts in space are undeniably related. Consequently, it is important to initiate close collaborations between orthopedic nutritionists and space experts, with the musculoskeletal-related dedications playing as common fuel.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Briguglio

2021

Nutrients

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“…En la electrocardiografía (ECG) se suelen presentar alteraciones electrofisiológicas inducidas por cambios moleculares y celulares que originan canalopatías y posteriormente miocardiopatías (28) , así como la presencia de extrasístoles ventriculares aisladas, arritmias malignas, riesgo de inestabilidad en la re-polarización, contracción auricular prematura, incremento del complejo QRS y del intervalo PR e inclusive muerte cardiaca súbita (13,22,29) .…”

Section: Pág 306unclassified

Medicina humana espacial: Performance fisiológico y contramedidas para mejorar la salud del astronauta

Rivera¹,

Cornejo²,

Huallpayunca³

et al. 2020

RFMH

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This Review Article is presented based on current scientific evidence on space medicine focused on human physiology and its countermeasures. Therefore, a non-systematic bibliographic search of scientific articles and research books in English-Spanish of the last 7 years was carried out, detailing their application in humans, murine models and in vitro experiments. The conditions of the space environment such as microgravity and radiation that produce considerable physiological changes in the cardiovascular system (redistribution of fluids, cardiovascular remodeling, arrhythmias) were taken into account; nervous (sensorimotor, neurosensory, neurovestibular); respiratory (volume and capacity changes); renal (lithiasis); musculoskeletal (muscular atrophy, osteoporosis); hematological (anemia); immunological (immune dysregulation) and digestive (intestinal microbiota disorder). In addition, there are biological, molecular and genetic processes still to be explored, in order to know and mitigate the uncertain mechanisms triggered in extreme and dangerous environments. Therefore, it is a priority to develop and implement countermeasures to reduce the harmful effects on health, with the aim of guaranteeing the astronaut's adaptation, safety and performance during future space flights.

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“…The angles between consecutive T waves were calculated from the preprocessed ECG signals by an updated method, defined in [12], based on the original method proposed in [6]. The method included the following steps: 1.…”

Section: Periodic Repolarization Dynamicsmentioning

confidence: 99%

Sudden Cardiac Death Prediction in Chronic Heart Failure Patients by Periodic Repolarization Dynamics

Palacios

Cygankiewicz

Bayés-de-Luna³

et al. 2020

2020 Computing in Cardiology Conference (CinC)

Self Cite

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Chronic heart failure (CHF) is a clinical syndrome associated with high mortality due to pump failure death (PFD) resulting from heart failure progression as well as to ventricular arrhythmias leading to sudden cardiac death (SCD). CHF involves autonomic nervous system imbalance, which is expected to be reflected in the electrocardiogram (ECG). Periodic Repolarization Dynamics (PRD) quantifies low-frequency oscillations in the T wave of the ECG and has been related to sympathetic modulation of ventricular repolarization. We assessed the capacity of PRD to predict PFD and SCD in a CHF population. 3-lead ECG recordings of 569 patients with symptomatic CHF were analyzed. PRD values were measured by analyzing 5-minute segments with 4-minute overlap. The minimum PRD value over the analyzed segments was assigned to each patient. PRD was higher in SCD victims than in PFD victims and than in survivors and non-cardiac death victims, although differences were not statistically significant. Low-and high-risk groups were defined by dichotomization according to median PRD in the population. Hazard ratio [95% Confidence Interval] for SCD from univariate Cox regression was 1.808 [1.031-3.169] deg (p=0.039). In conclusion, high PRD predicts SCD in a CHF population, with SCD victims presenting enhanced sympatheticinduced oscillations of ventricular repolarization.

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Long-Term Microgravity Exposure Increases ECG Repolarization Instability Manifested by Low-Frequency Oscillations of T-Wave Vector

Cited by 9 publications

References 65 publications

Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Medicina humana espacial: Performance fisiológico y contramedidas para mejorar la salud del astronauta

Sudden Cardiac Death Prediction in Chronic Heart Failure Patients by Periodic Repolarization Dynamics

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