Long-term Lung Abnormalities Associated with COVID-19                     Pneumonia

Kanne, Jeffrey P.; Little, Brent P.; Schulte, Jefree J.; Haramati, Adina; Haramati, Linda B.

doi:10.1148/radiol.221806

Cited by 41 publications

(16 citation statements)

References 104 publications

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Section: Discussionmentioning

confidence: 71%

“…In this context, our findings showing larger central conducting airway luminal area among patients with COVID-19 may have clinical implications for post-COVID conditions—also referred to as “long COVID”, “long-haul COVID”, or “post-acute sequelae of COVID-19” 34 . The larger airway luminal area may reflect traction bronchiectasis and could contribute to post-COVID respiratory symptoms 34 , 37 . Although no consensus currently exists for imaging management of patients with subacute COVID-19, our findings may suggest that enlarged central conducting airway luminal area may be a consideration in pulmonary sequelae among COVID-19 survivors.…”

Section: Discussionmentioning

confidence: 71%

“…The primary radiographic findings are ground-glass opacity and pulmonary consolidation—suggesting the possible presence of organizing pneumonia 8 . Although effective vaccines and therapeutics are available in many countries, about one-third of COVID-19 survivors have residual abnormalities on chest CT 1 year after COVID-19 34 . Thus, familiarity with sequelae of COVID-19 pneumonia on chest imaging may be important to evaluate potential causes of chronic residual abnormalities or respiratory symptoms after COVID-19 35 , 36 .…”

Section: Discussionmentioning

confidence: 99%

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Greater central airway luminal area in people with COVID-19: a case–control series

Jeltema

Gorman

Ovrom

et al. 2022

Sci Rep

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Respiratory epithelium in the conducting airways of the human body is one of the primary targets of SARS-CoV-2 infection, however, there is a paucity of studies describing the association between COVID-19 and physical characteristics of the conducting airways. To better understand the pathophysiology of COVID-19 on the size of larger conducting airways, we determined the luminal area of the central airways in patients with a history of COVID-19 compared to a height-matched cohort of controls using a case–control study design. Using three-dimensional reconstruction from low-dose high-resolution computed tomography, we retrospectively assessed airway luminal cross-sectional area in 114 patients with COVID-19 (66 females, 48 males) and 114 healthy, sex- and height-matched controls (66 females, 48 males). People with a history of smoking, cardiopulmonary disease, or a body mass index greater than 40 kg·m−2 were excluded. Luminal areas of seven conducting airways were analyzed, including trachea, left and right main bronchus, intermediate bronchus, left and right upper lobe, and left lower lobe. For the central conducting airways, luminal area was ~ 15% greater patients with COVID-19 compared to matched controls (p < 0.05). Among patients with COVID-19, there were generally no differences in the luminal areas of the conducting airways between hospitalized patients compared to patients who did not require COVID-19-related hospitalization. Our findings suggest that males and females with COVID-19 have pathologically larger conducting airway luminal areas than healthy, sex- and height-matched controls.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Greater central airway luminal area in people with COVID-19: a case–control series

Jeltema

Gorman

Ovrom

et al. 2022

Sci Rep

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“…The term “post-COVID interstitial lung disease” involves many uncertainties, as several groups have emphasized ( 29 ) ( 30 ) ( 31 ). Although many survivors of COVID-19 have residual lung parenchymal abnormalities, many of these abnormalities are mild, fibrosis is uncommon except in severe pneumonia, and a progressive course is not typical ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Chronic Pulmonary Manifestations of COVID-19 Infection: Imaging Evaluation

Murphy

Little

2023

Radiology

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“…This transition may act as a deep lever of change that allows for better multi-hazard management, which is of crucial importance given the fact that the COVID-19 management practices have significantly influenced and are influenced by risk mitigation practices that were designed prior to this global outbreak. The COVID-19 pandemic has caused severe and prolonged health problems (Poudel et al 2021 ; Kanne et al 2022 ; Vyas et al 2022 ), the overburdening of medical systems (Bigoni et al 2022 ; Chanda-Kapata et al 2022 ; Chemali et al 2022 ), social tensions (Donoso et al 2022 ; Fahs and Swank 2022 ; Rohlinger and Meyer 2022 ; Wood et al 2022 ), and economic disruptions (Choi et al 2022 ; Khetan et al 2022 ), increasing the vulnerability of human communities to other natural hazards and depleting their capacity to cope with hazards. On the other hand, certain hazard management practices hindered the implementation of COVID-19 preventive protocols (e.g., social distancing is difficult to maintain during evacuation procedures or in emergency shelters), damaged the medical and/or transport infrastructure, and negatively affected pandemic relief workers and volunteers (Shultz et al 2020 ; Ashraf 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the links between flood events and the COVID-19 infection cases in Romania in the new multi-hazard-prone era

Albulescu

2023

Nat Hazards

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The occurrence of flood events amid the COVID-19 pandemic represents a prominent part of the emerging multi-hazard landscape, as floods are one of the most frequent and destructive natural hazards. This spatial and temporal overlap of hydrological and epidemiological hazards translates into compounded negative effects, causing a shift in the hazard management paradigm, in which hazard interaction takes centre stage. This paper calls into question whether the river flood events that occurred during the COVID-19 pandemic in Romania and the way that they were managed had an impact on the infection with the SARS-CoV-2 virus at county scale. To this end, hazard management data concerning the flood events that were severe enough to impose the evacuation of the population were corroborated with COVID-19 confirmed cases data. A definite link between the flood events and the dynamics of COVID-19 cases registered in the selected counties is difficult to identify, but the analysis shows that all flood events were followed by various size increases in the COVID-19 confirmed cases at the end of the incubation time range. The findings are critically interpreted by providing viral load and social-related contexts, allowing a proper understanding of the interactions between concurrent hazards.

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Long-term Lung Abnormalities Associated with COVID-19 Pneumonia

Cited by 41 publications

References 104 publications

Greater central airway luminal area in people with COVID-19: a case–control series

Greater central airway luminal area in people with COVID-19: a case–control series

Chronic Pulmonary Manifestations of COVID-19 Infection: Imaging Evaluation

Exploring the links between flood events and the COVID-19 infection cases in Romania in the new multi-hazard-prone era

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