Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men.

Orentreich, Norman; Brind, Joel; Vogelman, Joseph H.; Andres, Reubin; Baldwin, Howard

doi:10.1210/jcem.75.4.1400863

Cited by 219 publications

(200 citation statements)

References 1 publication

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“…However, differences between responders and nonresponders in cortisol/DHEAS ratios revealed an association with age of onset. These findings are supported by investigations that reported that age and DHEA(S) concentrations are inversely correlated (Orentreich et al, 1992;Binello and Gordon, 2003;Ritsner et al, 2004).…”

Section: Commentsupporting

confidence: 74%

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

Ritsner

Gibel

Maayan

et al. 2005

Neuropsychopharmacol

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Dehydroepiandrosterone (DHEA) or their sulfate conjugate (DHEAS) (together abbreviated DHEA(S)) exert multiple effects in the central nervous system, and may be involved in the pathophysiological processes in schizophrenia. This prospective study aimed to investigate whether serum cortisol/DHEA(S) molar ratios are associated with response to antipsychotic treatment during the exacerbation of schizophrenia. Serum DHEA(S) and cortisol were determined at baseline, and 2 and 4 weeks later for 43 medicated schizophrenia inpatients with acute exacerbation. The patients were treated with stable doses of antipsychotic agents up to 2 weeks prior to entering the study and for the 4-week duration of the study after which they were classified as either responders or nonresponders to treatment. Findings suggest that responders had significantly higher serum cortisol levels and cortisol/DHEA(S) ratios compared with nonresponders. These differences remained significant at three time points controlling for gender, age, severity of symptoms and emotional distress, benzodiazepines, type or dosage of antipsychotic agents, and background variables. The logistic regression model shows advantages of both cortisol/DHEA(S) molar ratios vs serum cortisol and DHEA(S) concentrations for prediction of responsivity to antipsychotic treatment. No significant canonical correlations were observed between changes from baseline through end-of-study in hormonal values and severity of symptoms and emotional distress among responders and nonresponders. Thus, these data provide evidence that elevated serum cortisol and cortisol/DHEA(S) ratios may serve as markers of biological mechanisms that are involved in responsivity of schizophrenia patients to antipsychotic treatment.

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Section: Commentsupporting

confidence: 74%

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

Ritsner

Gibel

Maayan

et al. 2005

Neuropsychopharmacol

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“…DHEA and it's sulfated form, DHEAS, are present in adult men and women at serum levels 100 to 500 times higher than those of testosterone and 1000 to 10,000 times higher than those of estradiol but levels decrease up to 80% with age [1,14,15]. DHEA is widely used as an overthe-counter dietary supplement with unsubstantiated claims of beneficial effects on body composition, cardiometabolic, immune, and neurobiological functions [16] as well as uncertain long-term safety.…”

Section: Discussionmentioning

confidence: 99%

Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells

Arnold

Gray

Jacobowitz

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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Dehydroepiandrosterone (DHEA) is commonly used as a dietary supplement and may affect prostate pathophysiology when metabolized to androgens and/or estrogens. Human prostate LAPC-4 cancer cells with a wild type androgen receptor (AR), were treated with DHEA, androgens (DHT, T, or R1881), and E 2 and assayed for PSA protein and gene expression. In LAPC-4 monocultures, DHEA and E 2 induced little or no increase in PSA protein or mRNA expression compared to androgentreated cells. When prostate cancer-associated (6S) stromal cells were added in coculture, DHEA stimulated LAPC-4 cell PSA protein secretion to levels approaching induction by DHT. Also, DHEA induced 15-fold more PSA mRNA in LAPC-4 cocultures than in monocultures. LAPC-4 proliferation was increased 2-3 fold when cocultured with 6S stromal cells regardless of hormone treatment. DHEA-treated 6S stromal cells exhibited a dose-and time-dependent increase in T secretion, demonstrating stromal cell metabolism of DHEA to T. Coculture with non-cancerous stroma did not induce LAPC-4 PSA production, suggesting a differential modulation of DHEA effect in a cancerassociated prostate stromal environment. This coculture model provides a research approach to reveal detailed endocrine, intracrine, and paracrine signaling between stromal and epithelial cells that regulate tissue homeostasis within the prostate, and the role of the tumor microenvironment in cancer progression.

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“…1b, f;Plymate et al, 1989;Feldman et al 2002;Luboshitzky et al 2003;Garyfallou et al 2005;Kaufman and Vermeulen 2005;Page et al 2007;Schlatt et al 2008;Bremner 2010), and an even more pronounced attenuation of their 24-h DHEAS rhythm (Figs. 1d, h;Orentreich et al 1992;Labrie et al 1997;Wise 1999;Urbanski et al 2004;Downs et al 2008). An age-related decline has also been observed for leptin in old male rhesus macaques (data not shown; Downs and Urbanski 2006a).…”

Section: Age-related Endocrine Changesmentioning

confidence: 99%

Age-related changes in neuroendocrine rhythmic function in the rhesus macaque

Urbanski

Sorwell

2011

AGE

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Many environmental conditions show rhythmic changes across the 24-h day; these include changes in light intensity, ambient temperature, food availability, and presence or absence of predators. Consequently, many organisms have developed corresponding adaptations, which ensure that specific physiological and behavioral events occur at an appropriate time of the day. In mammals, the underlying mechanism responsible for synchronizing internal biochemical processes with circadian environmental cues has been well studied and is thought to comprise three major components: (1) photoreception by the retina and transmission of neural signals along the retinohypothalamic tract, (2) integration of photoperiodic information with an internal reference circadian pacemaker located in the suprachiasmatic nucleus, and (3) dissemination of circadian information to target organs, via the autonomic nervous system and through humoral pathways. Given the importance that neuroendocrine rhythms play in coordinating normal circadian physiology and behavior, it is plausible that their perturbation during aging contributes to the etiology of age-related pathologies. This mini-review highlights some of the most dramatic rhythmic neuroendocrine changes that occur in primates during aging, focusing primarily on data from the male rhesus macaques (Macaca mulatta). In addition to the ageassociated attenuation of hormone levels and reduction of humoral circadian signaling, there are also significant age-related changes in intracrine processing enzymes and hormone receptors which may further affect the functional efficacy of these hormones. Rhesus macaques, like humans, are large diurnal primates and show many of the same physiological and behavioral circadian changes during aging. Consequently, they represent an ideal translational animal model in which to study the causes and consequences of age-associated internal circadian disruption and in which to evaluate novel therapies.

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Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men.

Cited by 219 publications

References 1 publication

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells

Age-related changes in neuroendocrine rhythmic function in the rhesus macaque

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