Long-term kindling of the basolateral amygdala impairs copulatory behavior in male rats

Magyar, Orsolya; Hill, Matthew N.; Pinel, John P. J.; Gorzalka, Boris B.

doi:10.1016/j.neulet.2005.08.012

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…This increased latency to begin the sexual interaction was not associated with any motor alteration, as was demonstrated by the rats' adequate performance of motor copulatory responses. Like in this study, similar increased latencies to begin the sexual interaction have been shown after lesions to the prefrontal cortex [55], and after long-term kindling of the BLA [41]; hence, it is probably that males experience some difficulty in identifying the female as a sexual incentive.…”

Section: Discussionsupporting

confidence: 88%

“…injection) paired previously with copulation provoked an increased Fos-IR activation [38] as well as an increase in glucose utilization in the BLA [40]. Moreover, several studies have suggested the involvement of the BLA in modulating sexual behavior, mainly in relation to the sexual arousal associated with rewarding stimuli [38]- [41].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, a few studies suggest the involvement of the BLA in sexual interaction. For example, it has been shown that following 60 stimulations of the left BLA over a 4-week period (long-term kindling), male Long-Evans rats exhibited prolonged latencies in mounting, intromission and ejaculation and lower ejaculation frequencies [41].…”

Section: Introductionmentioning

confidence: 99%

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Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a T-Maze Task with a Sexual Reward

Hernández‐González¹,

Aguirre²,

Guevara³

et al. 2014

JBBS

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This study was aimed to determine the effect of amygdaline inactivation on the sexual motivation of male rats during a T-maze task with a sexual reward. Subjects were chronically implanted with two stainless-steel cannulae that enabled the infusion of tetrodotoxin, a sodium channel blocker, into the left and right basolateral amygdala (BLA). Animals were divided into 3 groups: saline (SS); TTX1 (tetrodotoxin at 2.5 ng); and TTX2 (tetrodotoxin at 5.0 ng). To induce a sexually-motivated state, all male rats were allowed to have an intromission with a receptive female before performing the T-maze task, after which their sexual motivation was evaluated during seven trials in which a receptive female was placed in one goal-box of the T-maze, and a non-receptive one in the other. Subjects were allowed an intromission as a sexual reward whenever they reached the goalbox containing the receptive female, but were returned to the start-box if they did not. At the end of the experiment, copulation until ejaculation was permitted. Both doses of TTX increased the time rats required to cross the maze stem during the final trials. In terms of sexual interaction, the high dose of TTX increased more markedly mount, intromission and ejaculation latencies and the number of mounts and intromissions. Overall, these results indicate that the BLA may play an important role in modulating sexual behavior, particularly in maintaining sexual motivation in successive trials in a T-maze task and during sexual interaction per se. * Corresponding author. M. Hernández-González et al. 224

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a T-Maze Task with a Sexual Reward

Hernández‐González¹,

Aguirre²,

Guevara³

et al. 2014

JBBS

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“…Other studies have conducted long-term kindling (66–99 stimulations) of the amygdala, hippocampus, or caudate nucleus in adult rats (Kalynchuk et al, 1998; Magyar et al, 2005; Fournier et al, 2013). While the long-term kindling did not induce SRS, kindled rats presented deficits or abnormalities in open-field activity, fear memory, and/or sexual behaviors.…”

Section: Discussionmentioning

confidence: 99%

Impaired Spatial Learning and Memory in Middle-Aged Mice with Kindling-Induced Spontaneous Recurrent Seizures

et al. 2019

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Temporal lobe epilepsy is the most common and often drug-resistant type of epilepsy in the adult and aging populations and has great diversity in etiology, electro-clinical manifestations, and comorbidities. Kindling through repeated brief stimulation of limbic structures is a commonly used model of temporal lobe epilepsy. Particularly, extended kindling can induce spontaneous recurrent seizures in several animal species. However, kindling studies in middle-aged, aging, or aged animals remain scarce, and currently, little is known about kindling-induced behavioral changes in middle-aged/aging animals. We therefore attempted to provide more information in this area using a mouse model of extended hippocampal kindling. We conducted experiments in middle-aged mice (C57BL/6, male, 12–14 months of age) to model new-onset epilepsy in adult/aging populations. Mice experienced twice daily hippocampal stimulations or handling manipulations for 60–70 days and then underwent continuous electroencephalogram (EEG)-video monitoring to detect spontaneous recurrent seizures. Extended kindled mice consistently exhibited spontaneous recurrent seizures with mean incidences of 6–7 events per day, and these seizures featured EEG discharges and corresponding convulsions. The handling control mice showed neither seizure nor aberrant EEG activity. The two groups of mice underwent the Morris water maze test of spatial learning and memory 1–2 weeks after termination of the kindling stimulation or handling manipulation. During visible platform trials, the kindled mice took a longer distance and required more time than the control mice to find the platform. During hidden platform trials, the kindled mice showed no improvement over 5-day trials in finding the platform whereas the control mice improved significantly. During probe tests in which the hidden platform was removed, the kindled mice spent less time than the controls searching in the correct platform location. There were no significant differences between the kindled and control mice with respect to swim speed or total locomotor activity in an open-field test. Together, these observations indicate that the extended kindled mice with spontaneous recurrent seizures are impaired in spatial learning and memory as assessed by the Morris water maze test. We postulate that the extended hippocampal kindling in middle-aged mice may help explore epileptogenic mechanisms and comorbidities potentially relevant to new-onset temporal lobe epilepsy in adult and aging patients. Limitations and confounds of our present experiments are discussed to improve future examinations of epileptic comorbidities in extended kindled mice.

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Seizures, but not lowered seizure thresholds, results in larger neocortical motor maps and concomitant disruptions in skilled motor behaviour

Flynn

Young

Teskey

2010

Behavioural Brain Research

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Long-term kindling of the basolateral amygdala impairs copulatory behavior in male rats

Cited by 3 publications

References 18 publications

Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a T-Maze Task with a Sexual Reward

Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a T-Maze Task with a Sexual Reward

Impaired Spatial Learning and Memory in Middle-Aged Mice with Kindling-Induced Spontaneous Recurrent Seizures

Seizures, but not lowered seizure thresholds, results in larger neocortical motor maps and concomitant disruptions in skilled motor behaviour

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