Long-Term Kidney and Cardiovascular Complications in Pediatric Cancer Survivors

Hypertension in Cardio-Oncology Clinic: an update on etiology, assessment, and management

“…While the mechanisms mentioned above could potentionally render Cyclophosphamide-associated Hypertension possible, it has not yet been recognized as an independent risk factor for hypertension in cancer patients. Hypertension was reported in pediatric cancer patients who were treated with ifosfamide [48].…”

“…Bortezomib [38] Carfilzomib [38] Everolimus [35] Myocarditis [100] arrhythmias, conduction abnormalities [100] pericardial diseases [100] interstitial nephritis glomerulonephritis [99,101] Acute kidney injury [101] cardiotoxicity [102][103][104] mTOR inhibitors • increased oxidative stress [34] sympathetic activation [34] Rapamycin Hyperglycemia [105], hypercholesterolemia [105], hypertriglyceridemia [105] CAR-T therapy fever, flu-like symptoms, low blood pressure, and organ damage [106] Ubiquitin-proteasome inhibitors [39,40,99] • blocking the β proteolytic subunits of the 20s proteasome bortezomib and carfilzomib muscle weakness and tingling [107] Traditional chemotherapeutic agents Alkylating agents • creating cross-linkage in DNA strands and cell death [43] • disturbance in renin-angiotensin system [48].…”

A dozen years of ovarian tissue cryopreservation at a pediatric hospital: tracking program and patient metrics while adapting to increasing needs

“…Rates of survival for pediatric cancers have improved, and aggregate 5-year survival rates now exceed 80% with most patients living into adulthood ( 1 ). Sixty percent of survivors of pediatric cancers will have a serious long-term complication that may include infertility ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ). Alkylating chemotherapeutics or radiation fields that include the hypothalamus or gonads cause a significantly increased risk for premature gonadal insufficiency and/or infertility ( 4 , 5 , 6 , 8 , 10 , 11 , 12 , 13 , 14 ).…”