Long-Term Intake of trans (n-3) Polyunsaturated Fatty Acids Reduces the b-Wave Amplitude of Electroretinograms in Rats

Acar, Niyazi; Chardigny, Jean‐Michel; Bonhomme, Brigitte; Almanza, S.; Doly, M.; Sébédio, Jean‐Louis

doi:10.1093/jn/131.10.3151

Cited by 23 publications

(15 citation statements)

References 24 publications

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“…In rats deprived from n-3 PUFA from 2 generations, the main finding concerning the retinal function was the decreased ERG a-wave and b-wave amplitudes. We already demonstrated that the isomerization of dietary α-linolenic acid decreased the ERG b-wave amplitude in rats [26,44]. Considering the typical pattern of retinal fatty acids (as described above), the defects observed here in the retinal function may be mainly the consequence of the decreased dietary intake of cis α-linolenic acid and subsequently the lack of cis DHA.…”

Section: Retinal Phospholipidssupporting

confidence: 69%

The retina is more susceptible than the brain and the liver to the incorporation oftransisomers of DHA in rats consumingtransisomers of alpha-linolenic acid

et al. 2006

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-Trans polyunsaturated fatty acids are formed during heat treatments of vegetable oils from polyunsaturated fatty acids containing cis double bonds. After dietary intake, they are distributed in the body and are incorporated into nervous tissues including the retina. Since nervous tissues are known to be rich in n-3 fatty acids such as docosahexaenoic acid (DHA), we studied the ability of the retina and the brain to incorporate trans isomers of DHA formed in vivo from the dietary precursor trans α-linolenic acid. Wistar rats were fed with trans isomers of α-linolenic acid for 21 months. A linear incorporation of trans DHA and a decrease in cis DHA was observed in the retina, whereas no major changes were observed in the brain. In parallel to the modifications in retinal cis and trans DHA levels, the retinal functionality evaluated by the electroretinogram showed defects in animals that consumed trans α-linolenic acid. These results suggest that the mechanisms leading to the incorporation of cis and trans fatty acids are quite different in the retina when compared to the brain and the liver, the retina being more susceptible to changes in the dietary lipid contribution.dietary trans polyunsaturated fatty acids / rat / retina / cerebral cortex / electroretinography

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Section: Retinal Phospholipidssupporting

confidence: 69%

The retina is more susceptible than the brain and the liver to the incorporation oftransisomers of DHA in rats consumingtransisomers of alpha-linolenic acid

et al. 2006

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“…The second group of thirty-four male Wistar rats (14 weeks old, 450-550 g body weight) was fed a n-3 PUFA deficient diet (n-3-depleted animals). These animals were issued from two generations of rats fed the n-3 PUFA deficient diet (13). All animals had ad libitum access to food and water.…”

Section: Methodsmentioning

confidence: 99%

Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3-depleted rats

Peltier

Malaisse²,

Portois³

et al. 2006

Int J Mol Med

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Abstract.A novel i.v. lipid preparation (MCT:FO) containing 80% medium chain-triacylglycerols and 20% fish oil was recently developed to rapidly replenish cell membrane phospholipids with omega 3 (n-3) polyunsaturated fatty acids (PUFA). In regard of this property, we investigated the effect of a single i.v. administration of MCT:FO on the recovery of cardiac function after ischemia in control and n-3-depleted rats. Results were compared with those obtained either with a control preparation, where FO was replaced by triolein (MCT:OO), or with saline. Saline (1 ml) or lipid preparation (also 1 ml) was injected as a bolus via the left saphenous vein. After 60 min the heart was removed and perfused for 20 min in normoxic conditions according to Langendorff. Thereafter, the heart was subjected to a 20 min zero-flow normothermic ischemia, followed by 40 min reperfusion. Cardiac mechanical and metabolic functions were monitored. In control rats, the previous administration of a lipid preparation (MCT:FO or MCT:OO) versus saline improved cardiac function during aerobic reperfusion post-ischemia. N-3-depleted rats showed decreased basal cardiac function and impaired recovery following ischemia. However, the bolus injection of MCT:FO opposed the deleterious effect of longterm n-3-deficiency and, in this respect, was superior to MCT:OO over the first 20 min of reperfusion. This novel approach to rapidly correct n-3 PUFA-deficiency might be clinically relevant and offer interesting perspectives in the management of acute ischemic accidents.

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“…The data are reported in g/100 g of diet. The extended composition of the mineral and vitamin mixes has been reported elsewhere (Acar et al, 2002).…”

Section: Animal Experimentsmentioning

confidence: 99%

Dietary cyclic fatty acids derived from linolenic acid do not exhibit intrinsic toxicity in the rat during gestation

Brétillon¹,

Roy

Pasquis³

et al. 2008

Animal

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Heating oils and fats may lead to cyclization of polyunsaturated fatty acids, especially those showing multiple double bonds like linolenic acid. Cyclohexenyl and cyclopentenyl fatty acids are subsequently present in some edible oils and these were suspected to induce metabolic disorders. When fed during gestation in the rat, cyclic fatty acids were historically reported to induce high mortality of the neonates. Nevertheless, none of these studies have been performed with cyclic fatty acids fed as triacylglycerols, limiting the nutritional value of the conclusions. Therefore, we assessed the toxicity of a diet containing 0.7% of cyclic fatty acids fed as triacylglycerols during gestation and the first days of life in the rat. In this work, we report no deleterious effect of cyclic fatty acids in the mothers and neonates. However, cyclic fatty acids induced a tremendous insulinopenia in the mothers and pups that was associated with the reduction of food intake in the gestating females. Such a finding may be a plausible explanation for the adverse effects of cyclic fatty acids observed previously with higher doses of cyclic fatty acids. Based on present data, on previous ones showing elimination of cyclic fatty acids, and considering their low amounts in the diet, we suggest that cyclic fatty acids formed from cyclization of linolenic acid are not a major concern for human safety.

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Long-Term Intake of trans (n-3) Polyunsaturated Fatty Acids Reduces the b-Wave Amplitude of Electroretinograms in Rats

Cited by 23 publications

References 24 publications

The retina is more susceptible than the brain and the liver to the incorporation oftransisomers of DHA in rats consumingtransisomers of alpha-linolenic acid

The retina is more susceptible than the brain and the liver to the incorporation oftransisomers of DHA in rats consumingtransisomers of alpha-linolenic acid

Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3-depleted rats

Dietary cyclic fatty acids derived from linolenic acid do not exhibit intrinsic toxicity in the rat during gestation

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