Long-term incidence of hypothyroidism after radiotherapy in patients with head-and-neck cancer

Tell, Roger; Lundell, G. E. F.; Nilsson, Bo; Sjödin, Helena; Lewin, Freddi; Lewensohn, Rolf

doi:10.1016/j.ijrobp.2004.03.020

Cited by 109 publications

(103 citation statements)

References 44 publications

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“…However, many other literature reports suggest that longer follow-up (latency as late as 20 years has been reported by one study) [20] for these patients could be appropriate. [9,17,21,23,28] For this reason, the incidence ratio of our results for HT may be increased with longer follow-up.…”

Section: Discussionmentioning

confidence: 83%

“…Similarly, some studies reported that the median periods for development of HT were between eight and 16 (range, 1-96) months. [3,5,17] For this reason, these findings suggest that post-RT HT should be considered during the entire follow-up period, especially during the first 18 months.…”

Section: Discussionmentioning

confidence: 96%

“…For instance, some studies indicate a higher incidence of HT among female patients [1,7,20] whereas other studies show no impact on the likelihood of developing HT on the basis of sex. [13,17,[21][22][23] Diaz et al [19] reported that smaller thyroid volume had an increased risk factor for post-RT HT. Moreover, Alterio et al [7] reported that women's thyroid glands were less affected by RT as they were smaller than men's.…”

Section: Discussionmentioning

confidence: 99%

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Post-radiotherapy hypothyroidism in head and neck cancers: When should we be concerned?

Çelık¹

2017

Kulak Burun Bogaz Ihtis Derg

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Objectives:This study aims to analyze the incidence of hypothyroidism (HT) in patients who underwent radiotherapy (RT) for head and neck cancers (HNC), and to determine risk factors. Patients and Methods:This study was a retrospective analysis of patients who were treated with RT alone or in combination with surgery and/or chemotherapy between January 2005 and May 2012. Patients were grouped according to the primary tumor site, TNM staging system, age, gender, total radiation dose (TRD), mean radiation dose of thyroid gland (MRT), neck dissection, and chemotherapy.Results: A total of 90 patients who were treated with RT were analyzed. The median age was 52±13 (range, 12-87) years. The histopathologic finding of 88 patients was squamous cell carcinoma, others were adenocystic carcinoma and undifferentiated carcinoma. The median follow-up of all patients after RT was 15 (range, 6-72) months. Post-radiotherapy HT was found in 31 patients (34.4%). In this group, clinical and subclinical HT was present in eight (26%) and 23 (74%) patients, respectively. Age younger than 60 years and increased MRT (especially mean thyroid dose 20 Gy<) were significant risk factors for post-radiotherapy HT (p<0.05). Conclusion:Physicians should pay more attention to HT in patients who were treated with RT for HNC during follow-up.Keywords: Head and neck cancers; hypothyroidism; mean radiation dose of thyroid gland; radiotherapy; thyroid gland. Sonuç: Hekimler, takip sırasında HNC için RT ile tedavi edilen hastalarda HT'ye daha fazla dikkat etmelidirler.Anahtar Sözcükler: Baş ve boyun kanserleri; hipotiroidizm; tiroid bezinin ortalama radyasyon dozu; radyoterapi; tiroid bezi.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Post-radiotherapy hypothyroidism in head and neck cancers: When should we be concerned?

Çelık¹

2017

Kulak Burun Bogaz Ihtis Derg

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“…Hypothyroidism may develop within the first year after radiotherapy, especially in patients under 20 years of age. After external radiotherapy, hypothyroidism develops at a median interval of 1.4-1.8 (range 0.3-7.2) years, but may continue to develop many years following therapy (Mercado et al 2001;Tell et al 2004). Approximately 30% of patients with solid tumors of the head and neck cancer treated with external radiotherapy develop hypothyroidism (Tami et al 1992).…”

Section: External Radiotherapymentioning

confidence: 99%

Treatment Related Hypothyroidism, a Viewpoint from Cancer Therapy and Hematopoietic Stem Cell Transplantation

Tsao¹,

Feng²

2012

Hypothyroidism - Influences and Treatments

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“…[13][14][15][16] Atualmente as recomendações internacionais apontam para uma vigilância da função tiroideia a cada 6-12 meses no seguimento destes doentes.…”

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Hipotiroidismo Secundário à Irradiação Cervical: Avaliação Sistemática da Função Tiroideia no Seguimento

et al. 2014

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Em 51,9% dos doentes foi efetuado o diagnóstico de hipotiroidismo entre os 9 e os 12 meses após o tratamento de radioterapia. Discussão: Da análise da literatura publicada, o hipotiroidismo constitui a complicação tiroideia radioinduzida mais frequente e afeta uma grande percentagem de doentes submetidos a radioterapia cervical com intenção curativa. Foi demonstrado que o risco de hipotiroidismo aumenta com o tempo após a exposição, contudo a incidência mais elevada parece ser nos dois primeiros anos após o tratamento. Da nossa análise obtivemos, aos 12 meses uma taxa de incidência global de hipotiroidismo de 18,6%, (grau 1 de 16,55% e grau 2 de 2,1%). Conclusão: Neste estudo foi encontrada uma incidência de hipotiroidismo correspondente aos valores mais baixos descritos em outros estudos publicados. O curto tempo de follow-up considerado nesta análise poderá justificar os resultados obtidos. Face aos resultados obtidos, e correlacionando-os com a literatura disponível, os autores consideram justificável e recomendável a inserção da avaliação sistemática da função tiroideia no protocolo de follow-up destes doentes. Palavras-chave: Neoplasias da Cabeça e Pescoço; Radioterapia; Hipotiroidismo; Estudos de Seguimento.

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Long-term incidence of hypothyroidism after radiotherapy in patients with head-and-neck cancer

Cited by 109 publications

References 44 publications

Post-radiotherapy hypothyroidism in head and neck cancers: When should we be concerned?

Post-radiotherapy hypothyroidism in head and neck cancers: When should we be concerned?

Treatment Related Hypothyroidism, a Viewpoint from Cancer Therapy and Hematopoietic Stem Cell Transplantation

Hipotiroidismo Secundário à Irradiação Cervical: Avaliação Sistemática da Função Tiroideia no Seguimento

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