Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas

K, Burczak; Gamian, Elżbieta; Kochman, Agata

doi:10.1016/s0142-9612(96)00076-2

Cited by 147 publications

(80 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PVA is a well-known biologically friendly polymer and has been developed for biomedical applications such as artificial pancreas, [13][14][15] synthetic vitreous body, 16 wound dressing, artificial skin, and cardiovascular device. 17,18 PVP is one of the most widely used polymers in medicine because of its solubility in water and its extremely low cytotoxicity. 19 A recent work described the topical application of PVP onto the skin for transdermal delivery of drugs.…”

Section: Introductionmentioning

confidence: 99%

Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles

Chen

et al. 2006

J of Applied Polymer Sci

207

View full text Add to dashboard Cite

The poly(vinyl alcohol)/poly(N-vinyl pyrrolidone) (PVA-PVP) hydrogels containing silver nanoparticles were prepared by repeated freezing-thawing treatment. The silver content in the solid composition was in the range of 0.1-1.0 wt %, the silver particle size was from 20 to 100 nm, and the weight ratio of PVA to PVP was 70 : 30. The influence of silver nanoparticles on the properties of PVA-PVP matrix was investigated by differential scanning calorimeter, infrared spectroscopy and UV-vis spectroscopy, using PVA-PVP films containing silver particles as a model. The morphology of freeze-dried PVA-PVP hydrogel matrix and dispersion of the silver nanoparticles in the matrix was examined by scanning electron microscopy. It was found that a three-dimensional structure was formed during the process of freezing-thawing treatment and no serious aggregation of the silver nanoparticles occurred. Water absorption properties, release of silver ions from the hydrogels and the antibacterial effects of the hydrogels against Escherichia coli and Staphylococcus aureus were examined too. It was proved that the nanosilver-containing hydrogels had an excellent antibacterial ability.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles

Chen

et al. 2006

J of Applied Polymer Sci

207

View full text Add to dashboard Cite

show abstract

“…Higher density of islet cells often results in reduced viability and necrosis at the center due to nutrient limitation. Smooth outer surface and hydrogels have been reported to improve the biocompatibility by the absence of interfacial tension, thus reducing protein adsorption, cell adhesion and fibrosis (Burczak et al, 1996). Nair et al studied the effect of degree of hydrophilicity on tissue response of polyurethane interpenetrating networks (IPN) (Nair et al, 1992).The results indicated that an increase in hydrophilicity of polyurethane -polyvinyl pyrrolidone IPN's elicited an inert tissue response.…”

Section: Macroencapsulationmentioning

confidence: 99%

Perspectives of Islet Cell Transplantation as a Therapeutic Approach for Diabetes Mellitus

Nair¹,

Aloysious²

2011

Tissue Engineering for Tissue and Organ Regeneration

View full text Add to dashboard Cite

“…70,71 Surprisingly, many groups have abandoned AN69 and have focused their research efforts on membranes prepared of polyvinylalcohol (PVA) which have been shown to allow for long-term survival of islet-tissue. 72,73 Some preclinical and clinical tests have been reported with extravascular macrocapsules. A commercial available macrocapsule, i.e., TheraCyt, allows, reportedly, for survival of pancreatic islets in monkeys for periods up to 8 weeks.…”

Section: Extravascular Macrocapsulesmentioning

confidence: 99%

“…For macrocapsules, studies to this reaction mainly focus on modifications of the membrane to reduce the response rather than on identifying the cells and immunology behind the response. 28,29,61,73,[84][85][86] As a consequence there is still insufficient insight in the pathogenesis of the foreign body response against macrocapsules and is it impossible to decide whether the responses are caused by e.g., geometry issues such as mechanical irritations in vivo or by physicochemical factors.…”

Section: Host Responses and Macroencapsulationmentioning

confidence: 99%

Treatment of Diabetes with Encapsulated Islets

Vos

Spasojević

Faas

2010

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

C ell encapsulation has been proposed for the treatment of a wide variety of diseases since it allows for transplantation of cells in the absence of undesired immunosuppression. The technology has been proposed to be a solution for the treatment of diabetes since it potentially allows a mandatory minute-to-minute regulation of glucose levels without side-effects. Encapsulation is based on the principle that transplanted tissue is protected for the host immune system by a semipermeable capsule. Many different concepts of capsules have been tested. During the past two decades three major approaches of encapsulation have been studied. These include (i) intravascular macrocapsules, which are anastomosed to the vascular system as AV shunt, (ii) extravascular macrocapsules, which are mostly diffusion chambers transplanted at different sites and (iii) extravascular microcapsules transplanted in the peritoneal cavity. The advantages and pitfalls of the three approaches are discussed and compared in view of applicability in clinical islet transplantation.

show abstract

Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas

Cited by 147 publications

References 16 publications

Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles

Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles

Perspectives of Islet Cell Transplantation as a Therapeutic Approach for Diabetes Mellitus

Treatment of Diabetes with Encapsulated Islets

Contact Info

Product

Resources

About