Long-term impacts of non-occupational wildfire exposure on human health: A systematic review

Gao, Yuan; Huang, Wenzhong; Pei, Yu; Xu, Ruijun; Yang, Zhengyu; Gasevic, Danijela; Ye, Tingting; Guo, Yuming; Li, Shanshan

doi:10.1016/j.envpol.2023.121041

Cited by 25 publications

(15 citation statements)

References 78 publications

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“…The long-term health impacts of wildfire smoke exposures also remain poorly understood. 107,108 These analyses are empirically challenging, as discussed in Section 6, because disentangling variations in wildfire 15 smoke exposure from factors correlated with health outcomes is increasingly difficult over longer time periods. However, as wildfires are a seasonal exposure that can contribute up to half of all ambient air pollution in some regions, 42 they are worth quantifying to understand optimal investments in control measures.…”

Section: Knowledge Gapsmentioning

confidence: 99%

Health effects of wildfires

Gould

Heft-Neal

Prunicki

et al. 2023

Preprint

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We review current knowledge on the trends and drivers of global wildfire activity, advances in the measurement of wildfire smoke exposure, and evidence on the health effects of this exposure. We discuss methodological issues in estimating the causal effects of wildfire smoke exposures on health. We conduct a systematic review and meta-analysis of the effects of wildfire smoke exposure on all-cause mortality and respiratory and cardiovascular morbidity. We conclude by highlighting high priority areas for future research, including leveraging recently-developed spatially and temporally resolved wildfire specific ambient air pollution data to improve estimates of the health effects of wildfire smoke exposure.

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Section: Knowledge Gapsmentioning

confidence: 99%

Health effects of wildfires

Gould

Heft-Neal

Prunicki

et al. 2023

Preprint

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“…CC BY 4.0 License. area of research (Grant and Runkle, 2022;Gao et al, 2023). Recent studies investigating Amazonian (Yu et al, 2022) and Canadian Boreal (Korsiak et al, 2022) wildfire emissions have highlighted an elevated risk of various cancers, surpassing the effects of non-wildfire PM emissions for equivalent exposure doses.…”

Section: Implementation Of Dust Updated Aging Schemesmentioning

confidence: 99%

Opinion: how are advances in aerosol science informing our understanding of the health impacts of outdoor particulate pollution?

El Haddad,

Daellenbach,

Modini

et al. 2023

Preprint

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Abstract. Air pollution poses the greatest environmental threat to human health, causing an estimated nine million premature deaths annually and accounting for 5 % of the global GDP. This opinion paper explores how advances in aerosol science inform our understanding of the health impacts of outdoor particulate pollution. In the article, we advocate for a shift from solely considering total particulate matter (PM) mass to utilizing specific PM components as metrics for health assessments. This will allow targeted evidence-based interventions, limiting the most harmful anthropogenic emissions, while exempting uncontrollable or non-detrimental components. Central to this shift is the availability of global long-term PM chemical composition data obtained through field observations and modelling outputs. These data will serve as the new foundation for identifying the most harmful chemical components in different regions. We discuss emerging modelling tools for personalized exposure estimation to these components, present the type of ambient observations needed for model evaluation and highlight key gaps in our fundamental understanding of emissions and their health effects. Through global PM chemical composition data, advancements in modelling tools, and collaboration between aerosol scientists and epidemiologists, we can gain a deeper understanding of how different PM components influence disease development. The reevaluation of air quality guidelines with a focus on specific PM components will be essential for fostering healthier environments, preventing diseases and building resilient communities.

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“…In this regard, BPA is present in amniotic fluid, urine, and breast milk, as well as in blood and placental samples from newborns (Chen et al, 2018; Mendonca et al, 2014; Shekhar et al, 2017), which makes it possible to explore the adverse effects of early BPA exposure on neurodevelopment. Epidemiological studies have found that prenatal exposure to BPA may contribute to preterm birth, impact health at birth, elevate the likelihood of systemic abnormalities or diseases, and lead to various health outcomes (Guo et al, 2023). The results of animal experiments have further emphasized the significance of pregnant females and fetuses as the primary population susceptible to BPA exposure, given that BPA may penetrate the placenta barrier and directly affect the fetus (Doerge et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to low-dose bisphenol A disrupts hippocampal DNA methylation and demethylation in male rat offspring

Wang,

Guo,

Ren

et al. 2024

Toxicol Ind Health

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Earlier research has demonstrated that developmental exposure to bisphenol A (BPA) has persistent impacts on both adult brain growth and actions. It has been suggested that BPA might obstruct the methylation coding of the genes in the brain. In this study, the methylation changes in the hippocampus tissue of male rat pups were examined following prenatal BPA exposure. Pregnant Sprague-Dawley rats were treated with either vehicle (tocopherol-stripped corn oil) or BPA (4, 40, or 400 μg/kg·body weight/day) throughout the entire duration of gestation and lactation. At 3 weeks of age, the male rat offspring were euthanized, and the hippocampus were dissected out for analysis. The expression levels of DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) and DNA demethylases (TET1, Gadd45a, Gadd45b, and Apobec1) were analyzed in the hippocampus by means of quantitative real-time polymerase chain reaction and Western blotting, respectively. The results showed that prenatal exposure to BPA upregulated the expression of enzymes associated with DNA methylation and demethylation processes in the hippocampus of male rat offspring. These findings suggest that prenatal exposure to a low dose of BPA could potentially disrupt the balance of methylation and demethylation in the hippocampus, thereby perturbing epigenetic modifications. This may represent a neurotoxicity mechanism of BPA.

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Long-term impacts of non-occupational wildfire exposure on human health: A systematic review

Cited by 25 publications

References 78 publications

Health effects of wildfires

Health effects of wildfires

Opinion: how are advances in aerosol science informing our understanding of the health impacts of outdoor particulate pollution?

Prenatal exposure to low-dose bisphenol A disrupts hippocampal DNA methylation and demethylation in male rat offspring

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