2013
DOI: 10.1155/2013/690382
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Long-Term Impact of Immunosuppressants at Therapeutic Doses on Male Reproductive System in Unilateral Nephrectomized Rats: A Comparative Study

Abstract: Cyclosporine, tacrolimus, and sirolimus are commonly used in renal transplant recipients to prevent rejection. However, information for comparative effects of these agents on the male productive system is extremely limited and controversial. In a physiologically and clinically relevant rat model of unilateral nephrectomy, we demonstrated that long-term oral administration of both cyclosporine and sirolimus at doses equivalent to the therapeutic levels used for postrenal transplant patients significantly affect… Show more

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Cited by 25 publications
(30 citation statements)
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“…This study results showed that cyclosporine A decreased the weight of the reproductive organs: testis, prostate and seminal vesicle compared with the control rats. Similarly, many previous studies stated that the consumption of cyclosporine A induces a dose‐dependent decline in the male reproductive organs' weights in rats (Chen et al, 2013; Pan et al, 2018; Türk et al, 2007). The results of this study showed that C. afer extract significantly increased weight of the reproductive organs (testis, prostate and seminal vesicle) during cyclosporine A toxicity.…”
Section: Discussionmentioning
confidence: 59%
“…This study results showed that cyclosporine A decreased the weight of the reproductive organs: testis, prostate and seminal vesicle compared with the control rats. Similarly, many previous studies stated that the consumption of cyclosporine A induces a dose‐dependent decline in the male reproductive organs' weights in rats (Chen et al, 2013; Pan et al, 2018; Türk et al, 2007). The results of this study showed that C. afer extract significantly increased weight of the reproductive organs (testis, prostate and seminal vesicle) during cyclosporine A toxicity.…”
Section: Discussionmentioning
confidence: 59%
“…Experimental studies on rats treated with Tac and CsA have shown testicular histology with various degrees of atrophy of seminiferous tubes and problems with spermiation (15,17). CsA and sirolimus at doses equivalent to the therapeutic levels are reported to have even stronger toxicity on rat spermatogenesis than Tac (34). In the present study, the limited number of patients and higher cumulative doses of CTX among the Tac-treated patients did not allow us to compare the effect of CsA and Tac on semen quality.…”
Section: Discussionmentioning
confidence: 60%
“…These drugs can cause reversible human male infertility with unclear etiology [50-54]. Specifically, rapamycin analog treatments caused a block in spermatogonial differentiation in a human patient [55] as well as in a study using rats, although no detailed analyses were performed [56]. Both treated humans and rats exhibit reduced testosterone (T) levels due to inhibition of the hypothalamic-pituitary-gonadal axis.…”
Section: Introductionmentioning
confidence: 99%