Long‐Term Impact of Bronchopulmonary Dysplasia on Pulmonary Function

Landry, Jennifer; Chan, Tiffany; Lands, Larry C.; Menzies, Dick

doi:10.1155/2011/547948

Cited by 87 publications

(86 citation statements)

References 36 publications

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“…Again, variable definitions of BPD were used. The majority of studies (n = 26) used case-control study design (18,19,22,23,25,28,29,32,34,35,37,39,41,42,44,45,54,56,59,62,63,66,67,70,71,75), and the remaining used either retrospective (n = 4) or prospective (n = 4) cohort study designs (20,24,36,43,49,52,57,60).…”

Section: N = 90mentioning

confidence: 99%

Understanding the Short- and Long-Term Respiratory Outcomes of Prematurity and Bronchopulmonary Dysplasia

Islam¹,

Keller

Aschner

et al. 2015

Am J Respir Crit Care Med

274

229

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Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease associated with premature birth that primarily affects infants born at less than 28 weeks' gestational age. BPD is the most common serious complication experienced by premature infants, with more than 8,000 newly diagnosed infants annually in the United States alone. In light of the increasing numbers of preterm survivors with BPD, improving the current state of knowledge of long-term respiratory morbidity for infants with BPD is a priority. We undertook a comprehensive review of the published literature to analyze and consolidate current knowledge of the effects of BPD that are recognized at specific stages of life, including infancy, childhood, and adulthood. In this review, we discuss both the short-term and long-term respiratory outcomes of individuals diagnosed as infants with the disease and highlight the gaps in knowledge needed to improve early and lifelong management of these patients.Keywords: bronchopulmonary dysplasia; respiratory outcomes; preterm birth At a Glance CommentaryScientific Knowledge on the Subject: Currently, there is no comprehensive review of what is known about the short-and long-term respiratory morbidity associated with prematurity and bronchopulmonary dysplasia (BPD). With contemporary improvements in treatment and technology, more infants born prematurely are surviving with poorly understood respiratory sequelae that will present unique challenges to pediatric and ultimately adult pulmonary providers.What This Study Adds to the Field: This review provides both clinicians and researchers with a comprehensive understanding of the range of pulmonary outcomes for survivors of BPD. In reviewing the literature, we have also summarized the research gaps in this field.The significant associations of preterm birth with adult health have become increasingly recognized through epidemiological research and clinical observations (1-3). Complications of preterm birth (,37 completed weeks of gestation) are most often seen in very preterm infants (28-31 wk gestation) and extremely preterm infants (,28 wk gestation) (4), although it is increasingly recognized that even modestly preterm infants are at increased risk of adverse health and developmental outcomes.Preterm birth predisposes individuals to the development of chronic respiratory disease in adulthood, including asthma and chronic obstructive pulmonary disease (COPD) (5). Worldwide, it has been estimated that more than 15 million babies (11% of live births) are born preterm. Health complications associated with preterm birth have recently been implicated as the cause of 36% (1.03 million) of neonatal deaths. Rates of preterm birth are increasing in most countries with reliable

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Section: N = 90mentioning

confidence: 99%

Understanding the Short- and Long-Term Respiratory Outcomes of Prematurity and Bronchopulmonary Dysplasia

Islam¹,

Keller

Aschner

et al. 2015

Am J Respir Crit Care Med

274

229

View full text Add to dashboard Cite

show abstract

“…Die Rehospitalisierungsrate aus pulmonaler Indikation ist bei ehemaligen Frühgeborenen mit einem Geburtsgewicht von < 1000 g und mit schwerer BPD signifikant häufiger (40 vs. 24 %) [6,[15][16][17].…”

Section: Klinische Symptome Im Säuglings-und Kindesalterunclassified

“…Sowohl bei der "alten" als auch bei der "neuen" BPD ist die pulmonalarterielle Hypertension einer der größten Risikofaktoren für die Sterblichkeit in den ersten Lebensjahren [16]. Die PHT begründet sich, neben der verminderten Alvoelarisierung, mit rarefizierter Kapillarisierung und damit verbundener reduzierter Gesamtkapillardurchmesser auch in einem Perfusions-Ventilations-Mismatch.…”

Section: Pulmonalarterielle Hypertensionunclassified

Bronchopulmonale Dysplasie und Langzeitfolgen

Urlichs

2016

Pneumologe

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Die bronchopulmonale Dysplasie ist eine Entwicklungsstörung der Lunge, der ein Abbruch der physiologischen intrauterinen Lungenreifung mit anschließend veränderter postnataler Entwicklung der Atemwege und Lunge zugrunde liegt. Die Folge ist eine chronische Lungenerkrankung mit persistierenden morphologischen und funktionellen Veränderungen.Betroffen sind v. a. Frühgeborene mit einem Geburtsgewicht von < 1500 g, bei denen die Häufigkeit in Deutschland entsprechend den aktuellen Daten des Früh-geborenennetzwerks (GNN) für die Jahre 2009-2013 mit 13,8 % und im Jahr 2014 sogar mit nur 11,3 % angegeben wird [34].

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“…44 Hospital readmissions in the first 2 years of life and FEV1 and FVC in patients between 8–15 years of age have been shown to be significantly associated with initial BPD severity. 53 …”

Section: Natural History Of Pulmonary Function Testing Measurementsmentioning

confidence: 99%

The Natural History of Bronchopulmonary Dysplasia

McEvoy

Aschner

2015

Clinics in Perinatology

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Long‐Term Impact of Bronchopulmonary Dysplasia on Pulmonary Function

Abstract: Initial BPD severity was an important predictor of pulmonary function abnormality and health care use during childhood.

Cited by 87 publications

References 36 publications

Understanding the Short- and Long-Term Respiratory Outcomes of Prematurity and Bronchopulmonary Dysplasia

Understanding the Short- and Long-Term Respiratory Outcomes of Prematurity and Bronchopulmonary Dysplasia

Bronchopulmonale Dysplasie und Langzeitfolgen

The Natural History of Bronchopulmonary Dysplasia

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