Long-term impact of ambient air pollution on preterm birth in Xuzhou, China: a time series study

Li, Sha; Peng, Lei; Wu, Xiaochang; Xu, Geng; Cheng, Peng; Hao, Jingwen; Huang, Zhaohui; Xu, Meng; Chen, Shuting; Zhang, Chao

doi:10.1007/s11356-021-13621-2

Cited by 15 publications

(6 citation statements)

References 66 publications

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“…Furthermore, we also found that PM 10 exposure during multiple periods was linked to increased risks of PTB occurrence among the subjects. In line with a study in Xuzhou, China, prenatal exposure to ambient PM 10 was significantly associated with PTB risk ( 31 ). Consistent with a prior study in natural conception ( 8 ), our findings not only found significant associations during the specific trimesters and the entire pregnancy, they also showed that the pre-pregnancy periods such as 85 days before oocyte retrieval might be vital windows susceptible to the adverse effects of air pollution in IVF patients.…”

Section: Discussionsupporting

confidence: 86%

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

et al. 2021

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Objectives: Exposure to air pollutants has been linked to preterm birth (PTB) after natural conception. However, few studies have explored the effects of air pollution on PTB in patients who underwent in vitro fertilization (IVF). We aimed to investigate the association between ambient air pollutants exposure and PTB risk in IVF patients.Methods: This retrospective cohort study included 2,195 infertile women who underwent IVF treatment from January 2017 and September 2020 in Hangzhou Women's Hospital. Totally 1,005 subjects who underwent a first fresh embryo(s) transfer cycle were analyzed in this study. Residential exposure to ambient six air pollutants (PM2.5, PM10, SO2, NO2, CO, O3) during various periods of the IVF timeline were estimated by satellite remote-sensing and ground measurement. Cox proportional hazards models for discrete time were used to explore the association between pollutants exposure and incident PTB, with adjustment for confounders. Stratified analyses were employed to explore the effect modifiers.Results: The clinical pregnancy and PTB rates were 61.2 and 9.3%, respectively. We found that PM2.5 exposure was significantly associated with an increased risk of PTB during 85 days before oocyte retrieval [period A, adjusted hazard ratio, HR=1.09, 95%CI: 1.02–1.21], gonadotropin start to oocyte retrieval [period B, 1.07 (1.01–1.19)], first trimester of pregnancy [period F, 1.06 (1.01–1.14)], and the entire IVF pregnancy [period I, 1.07 (1.01–1.14)], respectively. An interquartile range increment in PM10 during periods A and B was significantly associated with PTB at 1.15 (1.04–1.36), 1.12 (1.03–1.28), and 1.14 (1.01–1.32) for NO2 during period A. The stratified analysis showed that the associations were stronger for women aged <35 years and those who underwent two embryos transferred.Conclusions: Our study suggests ambient PM2.5, PM10, and NO2 exposure were significantly associated with elevated PTB risk in IVF patients, especially at early stages of IVF cycle and during pregnancy.

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Section: Discussionsupporting

confidence: 86%

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

et al. 2021

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“…To better characterize the potential nonlinear relationships between meteorological conditions and the outcomes, we fitted models repeatedly by varying the degrees of freedom (dfs) for ambient temperature and relative humidity from 3 to 10 . The choice of df values was determined using the Akaike Information Criterion (AIC), with lower AIC values indicating better model fit . Ultimately, we determined that the optimal df values for ambient temperature and relative humidity were 4 and 3, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…21 The choice of df values was determined using the Akaike Information Criterion (AIC), with lower AIC values indicating better model fit. 32 Ultimately, we determined that the optimal df values for ambient temperature and relative humidity were 4 and 3, respectively. We used random-effect logistic regression models to estimate the associations between ozone exposure and the risk of twin growth discordance, adjusting for the same covariates included in the linear mixed-effect models.…”

Section: Outcome Definitionmentioning

confidence: 99%

Evaluating the Impact of Maternal Exposure to Ozone on Twin Fetal Growth in China

Shen,

Zhang,

et al. 2023

Environ. Sci. Technol.

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“…That is a high rate worldwide, and further research on the impact factor and prevention is essential and needed in China. The studies on ambient air pollutants and preterm birth in China have delivered different conclusions in different regions [ 11 , 12 , 13 ]. Among the significant concerns that have been noted is the ambient air pollution associated with the increasing risk of preterm births.…”

Section: Introductionmentioning

confidence: 99%

Association between Maternal Exposure to Ambient Air Pollution and the Risk of Preterm Birth: A Birth Cohort Study in Chongqing, China, 2015–2020

Zhou

Ming²,

Yang³

et al. 2022

IJERPH

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Recent study results on the association between maternal exposure to ambient air pollution with preterm birth have been inconsistent. The sensitive window of exposure and influence level of air pollutants varied greatly. We aimed to explore the association between maternal exposure to ambient air pollutants and the risk of preterm birth, and to estimate the sensitive exposure time window. A total of 572,116 mother–newborn pairs, daily concentrations of air pollutants from nearest monitoring stations were used to estimate exposures for each participant during 2015–2020 in Chongqing, China. We applied a generalized additive model and estimated RRs and 95% CIs for preterm birth in each trimester and the entire pregnancy period. In the single-pollutant model, we observed that each 10 μg/m3 increase in PM2.5 had a statistically significant effect on the third trimester and entire pregnancy, with RR = 1.036 (95% CI: 1.021, 1.051) and RR = 1.101 (95% CI: 1.075, 1.128), respectively. Similarly, for each 10 μg/m3 increase in PM10, there were 2.7% (RR = 1.027, 95% CI: 1.016, 1.038) increase for PTB on the third trimester, and 3.8% (RR = 1.038, 95% CI: 1.020, 1.057) increase during the whole pregnancy. We found that for each 10 mg/m3 CO increases, the relative risk of PTB increased on the first trimester (RR = 1.081, 95% CI: 1.007, 1.162), second trimester (RR = 1.116, 95% CI: 1.035, 1.204), third trimester (RR = 1.167, 95% CI: 1.090, 1.250) and whole pregnancy (RR = 1.098, 95% CI: 1.011, 1.192). No statistically significant RR was found for SO2 and NO2 on each trimester of pregnancy. Our study indicates that maternal exposure to high levels of PM2.5 and PM10 during pregnancy may increase the risk for preterm birth, especially for women at the late stage of pregnancy. Statistically increased risks of preterm birth were associated with CO exposure during each trimester and entire pregnancy. Reducing exposure to ambient air pollutants for pregnant women is clearly necessary to improve the health of infants.

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Long-term impact of ambient air pollution on preterm birth in Xuzhou, China: a time series study

Cited by 15 publications

References 66 publications

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

Evaluating the Impact of Maternal Exposure to Ozone on Twin Fetal Growth in China

Association between Maternal Exposure to Ambient Air Pollution and the Risk of Preterm Birth: A Birth Cohort Study in Chongqing, China, 2015–2020

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