Long-term impact of acute restraint stress on heroin self-administration, reinstatement, and stress reactivity

Carter, Jordan S.; Kearns, Angela; Vollmer, Kelsey M.; García‐Keller, Constanza; Weber, Rachel; Baker, Nathaniel L.; Kalivas, Peter W.; Reichel, Carmela M.

doi:10.1007/s00213-020-05486-z

Cited by 15 publications

(17 citation statements)

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“…Presentation of the stress CS was sufficient to induce heroin-seeking in drug-treated rats. We have also shown that presentation of the stress CS dysregulates coping strategies in a defensive burying task (Carter et al, 2020;Garcia-Keller et al, 2021) increases corticosterone, and potentiates maladaptive plasticity in the nucleus accumbens core (Garcia-Keller et al, 2021). Importantly, these responses did not involve exposure to the primary stressor, but to a CS or "trigger" associated with the original stressor.…”

Section: Introductionmentioning

confidence: 82%

“…Previously, we paired a novel odor with the acute restraint stress experience [resulting in a stress conditioned stimulus, (CS)], then used this CS to activate stress associated memories in rats following heroin self-administration (SA; Carter et al, 2020). Presentation of the stress CS was sufficient to induce heroin-seeking in drug-treated rats.…”

Section: Introductionmentioning

confidence: 99%

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Complex Interactions Between Sex and Stress on Heroin Seeking

2021

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Rationale: Stress plays a dual role in substance use disorders as a precursor to drug intake and a relapse precipitant. With heroin use at epidemic proportions in the United States, understanding interactions between stress disorders and opioid use disorder is vital and will aid in treatment of these frequently comorbid conditions.Objectives: Here, we combine assays of stress and contingent heroin self-administration (SA) to study behavioral adaptations in response to stress and heroin associated cues in male and female rats.Methods: Rats underwent acute restraint stress paired with an odor stimulus and heroin SA for subsequent analysis of stress and heroin cue reactivity. Lofexidine was administered during heroin SA and reinstatement testing to evaluate its therapeutic potential. Rats also underwent tests on the elevated plus maze, locomotor activity in a novel environment, and object recognition memory following stress and/or heroin.Results: A history of stress and heroin resulted in disrupted behavior on multiple levels. Stress rats avoided the stress conditioned stimulus and reinstated heroin seeking in response to it, with males reinstating to a greater extent than females. Lofexidine decreased heroin intake, reinstatement, and motor activity. Previous heroin exposure increased time spent in the closed arms of an elevated plus maze, activity in a round novel field, and resulted in object recognition memory deficits.Discussion: These studies report that a history of stress and heroin results in maladaptive coping strategies and suggests a need for future studies seeking to understand circuits recruited in this pathology and eventually help develop therapeutic approaches.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Complex Interactions Between Sex and Stress on Heroin Seeking

2021

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“…In rodent models, it has been shown that exposure to stress is able to promote the capacity of psychostimulants to release dopamine in the nucleus accumbens (NA) ( Kalivas and Stewart, 1991 ; Pierce and Kalivas, 1997 ) and thus to enhance the locomotor response to a psychostimulant, a phenomenon known as cross-sensitization ( Marinelli and Piazza, 2002 ; Pacchioni et al, 2007 ; Sorg and Kalivas, 1991 ). Our previous reports in animal models of stress and substance use showed enduring neurobiological adaptations at glutamatergic synapses in the NA core, which underlie the development of behavioral sensitization ( Esparza et al, 2012 ; Garcia-Keller et al, 2013 ) and facilitate the acquisition of cocaine, alcohol and heroin self-administration (SA) ( Carter et al, 2020 ; Garcia-Keller et al, 2016 , 2019b ).…”

Section: Introductionmentioning

confidence: 99%

Stress-induced vulnerability to develop cocaine addiction depends on cofilin modulation

Rigoni

Avalos

Boezio

et al. 2021

Neurobiology of Stress

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Actin dynamics in dendritic spines can be associated with the neurobiological mechanisms supporting the comorbidity between stress exposure and cocaine increase rewards. The actin cytoskeleton remodeling in the nucleus accumbens (NA) has been implicated in the expression of stress-induced cross-sensitization with cocaine. The present study evaluates the involvement of cofilin, a direct regulator of actin dynamics, in the impact of stress on vulnerability to cocaine addiction. We assess whether the neurobiological mechanisms that modulate repeated-cocaine administration also occur in a chronic restraint stress-induced cocaine self-administration model. We also determine if chronic stress induces alterations in dendritic spines through dysregulation of cofilin activity in the NA core. Here, we show that the inhibition of cofilin expression in the NA core using viral short-hairpin RNA is sufficient to prevent the cocaine sensitization induced by chronic stress. The reduced cofilin levels also impede a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor surface expression enhancement and promote the reduction of head diameter in animals pre-exposed to stress after a cocaine challenge in the NA core. Moreover, downregulation of cofilin expression prevents facilitation of the acquisition of cocaine self-administration (SA) in male rats pre-exposed to chronic stress without modifying performance in sucrose SA. These findings reveal a novel, crucial role for cofilin in the neurobiological mechanisms underpinning the comorbidity between stress exposure and addiction-related disorders.

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“…As for the relationship between social stress and addictive behaviour, exposure to social defeat by stress also induces behavioural sensitisation to a subsequent amphetamine challenge in rats [ 70 ]. Furthermore, stress increases the rate of acquisition of heroin self-administration in rats [ 71 ]. Additionally, exposure to social stress during adolescence leads to increased cocaine self-administration and cocaine-induced conditioned place preference in mice [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

Sánchez-Salvador

Prados-Pardo

Martín-González

et al. 2021

IJERPH

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Inhibitory control deficit and impulsivity and compulsivity behaviours are present in different psychopathological disorders such as addiction, obsessive-compulsive disorders and schizophrenia, among others. Social relationships in humans and animals are governed by social organization rules, which modulate inhibitory control and coping strategies against stress. Social stress is associated with compulsive alcohol and drug use, pointing towards a determining factor in an increased vulnerability to inhibitory control deficit. The goal of the present review is to assess the implication of social stress and dominance on the vulnerability to develop impulsive and/or compulsive spectrum disorders, with the aid of the information provided by animal models. A systematic search strategy was carried out on the PubMed and Web of Science databases, and the most relevant information was structured in the text and tables. A total of 34 studies were recruited in the qualitative synthesis. The results show the role of social stress and dominance in increased drug and alcohol use, aggressive and impulsive behaviour. Moreover, the revised studies support the role of Dopaminergic (DA) activity and the alterations in the dopaminergic D1/D2 receptors as key factors in the development of inhibitory control deficit by social stress.

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Long-term impact of acute restraint stress on heroin self-administration, reinstatement, and stress reactivity

Cited by 15 publications

References 49 publications

Complex Interactions Between Sex and Stress on Heroin Seeking

Complex Interactions Between Sex and Stress on Heroin Seeking

Stress-induced vulnerability to develop cocaine addiction depends on cofilin modulation

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

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