Long-term immunogenicity of influenza vaccine among the elderly: Risk factors for poor immune response and persistence

Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases

“…Nevertheless, even in the absence of genetic drift, there has been a noted persistent problem over time of waning immunity induced by the influenza vaccines. Depending on the vaccine administered, the study population, and the method of quantifying immunity, protective immunity to influenza virus wanes between 6 and 18 months after vaccine administration (4,31,32). The events involved in diminished protection induced by influenza vaccines were the focus of two presentations at the workshop, each of which generated much discussion.…”

Antibody persistence after Pandemic H1N1 2009 influenza vaccination among healthcare workers in Pune, India

“…10 Seroprotection rate in all age groups declined markedly over the 12-mo period in a study of seasonal trivalent vaccine in Korea. 11 Such evidence is needed in guiding the vaccination policies for optimal timing of vaccination campaigns in relation to influenza seasonality. Influenza…”

Persistence of influenza vaccine-induced antibody in lung transplant patients and healthy individuals beyond the season

“…Influenza antibody concentrations persist at seroprotective levels (defined as antibody concentrations at least 40 hemagglutination units 8 ) up to a year post vaccination. 9,10 However, we could find no information regarding persistence beyond one year. We Background: The timing of influenza vaccination and susceptibility to re-circulating virus in the population is influenced by the persistence of seroprotection.…”