Long-term hyperalgesia induced by neonatal β-endorphin and morphiceptin is blocked by neonatal Tyr-MIF-1

Zadina, James E.; Kastin, Abba J.; Manasco, Penelope K.; Pignatiello, Michael F.; Nastiuk, Kent L.

doi:10.1016/0006-8993(87)90736-0

Cited by 41 publications

(12 citation statements)

References 18 publications

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“…MIF-1, like Tyr-MIF-1, can exert effects that persist into the adult stage after neonatal administration [10,11,21], In adult rats, MIF-1 facilitates sexual behavior in fe males but not in males [22], and Tyr-MIF-1 can increase plasma concentrations of LH [23]. These reports, like the results of the present study, suggest a relationship be tween Tyr-MIF-1 and the sex of the animal.…”

Section: Discussionsupporting

confidence: 73%

Age- and Sex-Related Changes in Tyr-MIF-1-Like Immunoreactivity in Rat Plasma

et al. 1992

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The concentrations in plasma of the biologically active endogenous peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH₂) have not been measured during development or in female rats. By radioimmunoassay, we found that Tyr-MIF-1 -like immunoreactivity (Tyr-MIF-1-LI) was first consistently detectable in plasma when the rat was 5 days old, and then gradually increased to adult concentrations by day 15. In male rats, the levels remained relatively constant for the next 21 months. In female rats, plasma concentrations of Tyr-MIF-l-LI at day 15 were about the same as in male rats. At 6 months of age, however, the concentrations in females decreased by half and by 21 months of life were only about a third of the concentrations found at day 15 or in age-matched males. The differences with age were not due to the length of time of storage of the samples, because another group of rats 1 month old was killed on the same day as 5-day-old rats and still showed several times more Tyr-MIF-1-LI in the plasma; again, no differences were found between male and female rats at either 5 days or 1 month. A single injection of estradiol followed by progesterone lowered the concentrations in 1-month-old male rats. In female rats that were either ovariectomized or sham-ovariectomized, the expected similarity in their plasma concentrations of Tyr-MIF-1-LI was found at 1 month of age. By contrast, at 2 and 12 months of age, ovariectomized rats had several times more Tyr-MIF-1-LI in their plasma than the sham operated female controls, as would be seen in male rats. The results indicate a significant interaction of sex with age in concentrations of Tyr-MIF-l-LI in the plasma of rats.

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Section: Discussionsupporting

confidence: 73%

Age- and Sex-Related Changes in Tyr-MIF-1-Like Immunoreactivity in Rat Plasma

et al. 1992

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“…Previous studies indicate that prenatal exposure to elevated endogenous opiates results in depressed performance of learning tasks, decreased exploration and elevated pain thresholds in adult animals exposed prenatally to elevated levels of opiates [Sandman and Kastin, 1981;Zadina et al, 1987], 'permanent' downregulation of dopamine receptors [Sandman and Yessian, 1986], reduced numbers of opioid receptors in the brain [Insel et al, 1990], increased opioid levels in the hypothalamus [Sanchez et al, 1993], and reduced benzodiazepine inhibitory activity [Fride et al, 1985]. Prenatal exposure to morphine results in altered seizure thresholds [Veliskova et al, 1999], increased grooming and pinning, altered sensitivity of endogenous opiate receptors [Niesink et al, 1999] and lower incidence of respiratory distress (probably related to increased lung maturation) [Gewolb et al, 1999].…”

Section: Discussionmentioning

confidence: 99%

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Sandman¹,

Glynn²,

Wadhwa

et al. 2003

Dev Neurosci

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Maternal peptides from the hypothalamic-pituitary-adrenal (HPA) axis rise during human pregnancy. The effects of circulating maternal adrenocorticotropin (ACTH) and β-endorphin (BE) on human fetal behavior was determined in 135 women during their 32nd week of gestation. Fetal behavior was measured by assessing heart rate habituation to a series of repeated vibroacoustic stimuli. Individual differences in habituation were determined by computing the number of consecutive responses above the standard deviation during a control period. There was no significant relation between levels of ACTH, BE and the rate of fetal heart rate habituation. However, an index of HPA disregulation (uncoupling of ACTH and BE) was related significantly to fetal behavior. Fetal exposure to high levels of maternal BE relative to ACTH was associated with significantly lower rates of habituation. Results indicate that maternal stress and stress-related peptides influence fetal response patterns. It is possible that this influence persists over the life span.

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“…Post-natal administration of morphine (1 lag/rat, SC) daily over the first 7 days of life subsequently increased mu opiate receptor binding, decreased hot-plate latencies and impaired motor activity in adult rats (Handelmann and Quirion 1983;Handelmann and Dow-Edwards 1985). Similarly, post-natal administration of beta-endorphin (1, 10 or 50 lag/rat, SC) over the first 7 days of life also decreased tail-flick and hot-plate latencies both in pups at 9 days of age and in adults; decreases in brain opiate receptors were also observed following treatment (Zadina et al 1985(Zadina et al , 1987Zadina and Kastin 1986). The analgesic response to morphine in 14-day-old pups, and the analgesic response to warm water swims in adult rats each failed to be affected by post-natal betaendorphin treatment (Zadina et al 1987).…”

mentioning

confidence: 59%

“…Similarly, post-natal administration of beta-endorphin (1, 10 or 50 lag/rat, SC) over the first 7 days of life also decreased tail-flick and hot-plate latencies both in pups at 9 days of age and in adults; decreases in brain opiate receptors were also observed following treatment (Zadina et al 1985(Zadina et al , 1987Zadina and Kastin 1986). The analgesic response to morphine in 14-day-old pups, and the analgesic response to warm water swims in adult rats each failed to be affected by post-natal betaendorphin treatment (Zadina et al 1987). In contrast, if perinatal beta-endorphin (50 lag/rat, SC) administration begins after the 1st post-natal day, adult tail-flick latencies are increased (Sandman et al 1979), indicating the importance of procedural variables.…”

mentioning

confidence: 76%

“…In contrast, if perinatal beta-endorphin (50 lag/rat, SC) administration begins after the 1st post-natal day, adult tail-flick latencies are increased (Sandman et al 1979), indicating the importance of procedural variables. The increases in hot-plate and tail-flick latencies by beta-endorphin and morphiceptin, a mul agonist, were blocked by neonatal Tyr-MIF-1 (Zadina et al 1987). Administration of morphine during pregnancy reduces adult morphine analgesia in the offspring (Johannesson and Becker 1972;Huidobro and Huidobro 1973;Steele and Johannesson 1975;O'Callaghan and Holtzman 1976;Horvious and Peters 1984).…”

mentioning

confidence: 91%

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Post-natal morphine differentially affects opiate and stress analgesia in adult rats

Arjune

Bodnar

1989

Psychopharmacology

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Alterations in nociceptive reactivity, opiate receptor binding, and other behavioral responses occur in rats exposed to morphine either in utero or post-natally. The present study examined whether post-natal morphine (0, 1 or 20 micrograms, days 1-7) altered analgesia on the tail-flick and jump tests induced by nonopioid-mediated continuous cold-water swims (CCWS), opioid-mediated intermittent cold-water swims (ICWS) or morphine (2.5 and 5.0 mg/kg, SC) in adult male and female rats. Changes in body weight, developmental signs (e.g., eye opening), basal pain thresholds, and both CCWS and ICWS hypothermia were also assessed. Previously-reported gender differences occurred for all forms of analgesia in control rats. Post-natal morphine treatment transiently increased ICWS analgesia and hypothermia, and transiently decreased CCWS analgesia and hypothermia, suggesting that these effects were not specific to pain inhibition. Post-natal morphine treatment significantly increased the magnitude of morphine analgesia on both tests in females, and significantly decreased the magnitude of morphine analgesia on both tests in males, thereby acting to vitiate the observed gender differences in morphine analgesia. Such effects could not be explained by concomitant changes in other measures. These data indicate that post-natal morphine treatment exerts highly selective effects upon specific analgesic responses which are gender sensitive.

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Long-term hyperalgesia induced by neonatal β-endorphin and morphiceptin is blocked by neonatal Tyr-MIF-1

Cited by 41 publications

References 18 publications

Age- and Sex-Related Changes in Tyr-MIF-1-Like Immunoreactivity in Rat Plasma

Age- and Sex-Related Changes in Tyr-MIF-1-Like Immunoreactivity in Rat Plasma

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Post-natal morphine differentially affects opiate and stress analgesia in adult rats

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