Long‐term histological prognosis and serum fibrosis markers in chronic hepatitis C patients treated with interferon

Abstract

Normalization of serum ALT levels after interferon therapy led to a histological improvement, and that with viral clearance achieved histological cure. Serum fibrosis markers were useful indicators for long-term according to the response of IFN therapy.

Progression of fibrosis in hepatitis C with and without schistosomiasis: Correlation with serum markers of fibrosis

“…Some studies have also shown that successful therapy of HCV can be associated with a reduction in serum markers of fibrosis such as PIIINP, 38,39 but there are no long-term studies on the role of markers in predicting resolution or stabilization of fibrosis. This study represents a truly unique cohort of patients followed sequentially for almost 10 years and thus is an excellent model for fibrosis studies such as this one.…”

Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B

“…Sinusoidal capilarization could be associated with shunting of blood which is an additional factor for increase of serum hyaluronate in this condition [35]. It was shown that serum hyaluronate increase in alcoholic liver disease [5,20,35], primary billiary cirrhosis [19] and in patients with hepatitis C [12,36]. In addition, it could be increased in rheumatoid disease due to overproduction by synovial cells [34,38].…”

Histological response study of chronic viral hepatitis C patients treated with interferon alone or combined with ribavirin

“…Furthermore, it has also been proven through several clinical trials that interferon-based treatments provoke histological improvements, even in virological non-responders [17][18][19][20][21][22]. We evaluated hepatic fibrosis and necro-inflammatory activity progression in chronic hepatitis C patients who were nonresponders to interferon-based treatments or relapsers.…”