Long-term high-temperature and pH stability assessment of modern commercially available stationary phases by using retention factor analysis

Haun, Jakob; Oeste, K.; Teutenberg, Thorsten; Schmidt, Torsten

doi:10.1016/j.chroma.2012.09.031

Cited by 17 publications

(12 citation statements)

References 34 publications

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“…The interested reader is referred to the dedicated literature, where the test conditions and columns are described in detail. 2,[113][114][115] …”

Section: Silica-based Stationary Phasesmentioning

confidence: 99%

High-Temperature Liquid Chromatography

Teutenberg

2015

Fast Liquid Chromatography–Mass Spectrometry Methods in Food and Environmental Analysis

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In recent years, the use of elevated temperatures in liquid chromatography has become more familiar, although many people still fear to increase the temperature because of unwanted side effects. In most laboratories, separations are usually performed at room temperature. In this setting, elevated-temperature liquid chromatography would mean the temperature ranges from 40 °C to 60 °C, whereas high-temperature liquid chromatography extends from 60 °C to 200 °C. The lower temperature limit of 60 °C is defined by the fact that some solvents that are used in liquid chromatography start to boil above that temperature, 1 while the upper temperature limit is dictated by the column stability. Most stationary phases are not stable if the temperature is increased above 150 °C, although it would be very easy to heat a column to a much higher temperature. In fact, only a few stationary phases can be used with an acceptable lifetime between 150 °C and 200 °C. 2 In the literature, many different terms have been used. These are:• Subcritical water chromatography 3-16 • Elevated-temperature liquid chromatography 17-39 • Superheated water chromatography 40-59 • Hot eluent liquid chromatography 60 Fast Liquid Chromatography-Mass Spectrometry Methods in Food and Environmental Analysis Downloaded from www.worldscientific.com by CHINESE UNIVERSITY OF HONG KONG on 02/08/15. For personal use only.

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“…The interested reader is referred to the dedicated literature, where the test conditions and columns are described in detail. 2,[113][114][115] …”

Section: Silica-based Stationary Phasesmentioning

confidence: 99%

High-Temperature Liquid Chromatography

Teutenberg

2015

Fast Liquid Chromatography–Mass Spectrometry Methods in Food and Environmental Analysis

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“…An Agilent 1200 SL HPLC instrument was used coupled via dual-sprayer electrospray ionization (ESI) to an Agilent 6220 Accurate-Mass-TOF mass spectrometer. All measurements were made on a Waters XBridge column (50 9 2.1 mm, 2.5 lm), chosen for its good temperature and pH stability, to minimize signals on mass spectrometry caused by column bleed [14].…”

Section: Liquid Chromatography-mass Spectrometrymentioning

confidence: 99%

Composition of Commercial Bis(2‐ethylhexyl) Sulfosuccinate Surfactant By‐Products and their Effects on an Agrochemical Formulation

Glaubitz¹,

Molt²,

Schmidt³

2014

J Surfact & Detergents

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Sodium bis(2‐ethylhexyl) sulfosuccinate (known as AOT) is a commercially available surfactant commonly used in agrochemicals. Besides the principal diester surfactant, the commercial AOT product contains two surface‐active isomeric monoester by‐products, which may influence the surfactant's overall properties. This work investigates whether the purity of the surfactant affects its ability to stabilize an agrochemical formulation. The concentrations of the diester and two monoester impurities in batches of commercial AOT product from several suppliers were determined quantitatively by liquid chromatography–mass spectrometry. The tested batches showed different contents of the monoesters. Samples of a model agrochemical formulation containing the AOT product formed more sediment during storage when the content of monoesters in the surfactant was high. The supplier of an commercial AOT product could be traced by analysis of the monoester content of either the raw product or the aged agrochemical formulation.

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“…Thus, temperature can be regarded as an important parameter to enhance separation efficiency, speed up analysis, and manipulate the selectivity of a chromatographic separation [1][2][3][4]. Although there have been a large number of research papers on HTLC published in the literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], the routine use of this technique is still not accepted in industry. One major reason for that is the stability of the stationary phase under high-temperature liquid chromatography conditions.…”

Section: Introductionmentioning

confidence: 98%

“…Over the years, columns with enhanced upper temperature limit have been developed, and in turn, this development has allowed the use of high-temperatures in liquid chromatography (HTLC) [5][6][7][8][9][10][11][12]. Most of these more thermally stable columns are packed with hybrid silica-or zirconia-based particles while fewer polymer columns are available for HTLC separations [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%