Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity–related proteins in the hippocampus

Li, Q.; Zhao, Haifeng; Zhang, Z.F.; Liu, Z.G.; Pei, Xinrong; Wang, J.B.; Li, Y.

doi:10.1016/j.neuroscience.2009.07.014

Cited by 149 publications

(127 citation statements)

References 44 publications

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“…Furthermore, green tea flavanol intake prevented reductions in the levels of key proteins involved in synaptic plasticity and structural plasticity, such as BDNF, postsynaptic density protein-95 and Ca 2 + /calmodulindependent protein kinase II (96) (Table 2). In support of this, another study using healthy, aged animals highlighted similar beneficial effects of green tea flavanols (6-month intervention) on spatial memory, along with increased levels of hippocampal CREB phosphorylation and increased levels of some of its target genes, such as BDNF and Bcl-2 (146) .…”

Section: Green Teamentioning

confidence: 99%

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro

Guerreiro

et al. 2012

Proc. Nutr. Soc.

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There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs. Flavonoids: Memory: Learning: HippocampusDiet is an important lifestyle factor, which in recent times has been investigated for its influence on cognitive function and the incidence and onset of neurodegenerative disorders (1,2) . It has long been known that a diet high in saturated fats negatively impacts on cognitive processing and increases the risk of neurological dysfunction in both animals and human subjects (3,4) , while energy restriction (reduction in approximately 30 % energy intake) protects the brain from injury (5,6) . Recently, significant evidence has emerged to indicate that phytochemical-rich foods, and in particular those rich in flavonoids, may reverse agerelated deficits in cognitive function in both animals and human subjects (7)(8)(9) . For example, the PAQUID prospective study examined cognitive performance in 1640 subjects (aged at least 65 years and cognitively normal at baseline) on four occasions over a 10-year-period and found that flavonoid-intake was associated with a significantly better cognitive performance over time (7) (P = 0 . 046). Furthermore, a cross-sectional study examining the relationship between the intake of three common flavonoid-containing foods (chocolate, wine and tea) and cognitive performance in elderly individuals revealed that there was a dose-dependent, positive relationship between the intake of these foods and performance on multiple cognitive outcomes (Kendrick Object Learning Test, Digit Symbol Test, Block Design, Mini-Mental State Examination and Controlled Oral Word Association Test) (10) . More recently, the consumption of dietary flavonoids, especially

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Section: Green Teamentioning

confidence: 99%

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro

Guerreiro

et al. 2012

Proc. Nutr. Soc.

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“…It is involved in AD because reductions of Aβ using antibodies or antisense oligonucleotides improve learning and memory in these mice [36,40,78]. In addition, recent results using long-term green tea catechin administration prevented spatial learning and memory decline in SAMP8 by decreasing Aβ 1-42 oligomers and upregulating synapticplasticity-related proteins in the hippocampus [79].…”

Section: Histopathological Similarities In Samp8 and Admentioning

confidence: 99%

Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model

Pallàs

2012

ISRN Cell Biology

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The causes of aging remain unknown, but they are probably intimately linked to a multifactorial process that affects cell networks to varying degrees. Although a growing number of aging and Alzheimer's disease (AD) animal models are available, a more comprehensive and physiological mouse model is required. In this context, the senescence-accelerated mouse prone 8 (SAMP8) has a number of advantages, since its rapid physiological senescence means that it has about half the normal lifespan of a rodent. In addition, according to data gathered over the last five years, some of its behavioral traits and histopathology resemble AD human dementia. SAMP8 has remarkable pathological similarities to AD and may prove to be an excellent model for acquiring more in-depth knowledge of the age-related neurodegenerative processes behind brain senescence and AD in particular. We review these facts and particularly the data on parameters related to neurodegeneration. SAMP8 also shows signs of aging in the immune, vascular, and metabolic systems, among others.

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“…For instance, the beneficial effects of green tea, blueberry and Gingko Biloba on spatial memory have been shown to involve increases in hippocampal brain-derived neurotrophic factor (BDNF) [23,[31][32][33]. The conversion of shortterm memory (STM) into long-term memory (LTM) is regulated at the molecular level in neurons [34][35][36] and involves the synthesis of new proteins that control neuronal morphology and connectivity [37].…”

Section: Introductionmentioning

confidence: 99%

Association Between Psychiatric Disorders and Iron Defi ciency Anemia Among Children And Adolescents: A Nationwide Population-Based Study

Croft¹

2015

Prenatal and Childhood Nutrition

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Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w), results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively), to a similar extent to that following blueberry supplementation (p = 0.002). These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p,0.01), suggesting a common mechanism for the enhancement of memory. However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods.

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Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity–related proteins in the hippocampus

Cited by 149 publications

References 44 publications

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model

Association Between Psychiatric Disorders and Iron Defi ciency Anemia Among Children And Adolescents: A Nationwide Population-Based Study

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