Long-term functional results of aspiration and sclerotherapy with ethanol in patients with autosomal dominant polycystic kidney disease: a non-randomized pilot clinical study

Küçük, Eyüp Veli; Tahra, Ahmet; Bindayı, Ahmet; Suçeken, Ferhat Yakup; Önol, Fikret Fatih; Boylu, Uğur

doi:10.1007/s11255-015-1211-x

Cited by 5 publications

(7 citation statements)

References 21 publications

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“…13 Mechanical cyst reduction strategies, such as cyst aspiration and sclerosis with ethanol or laparoscopic cyst decortication, have been used for decades in an effort to relieve the pain associated with large cysts and/or large kidneys, with success rates for pain relief varying from 25% to 100% and follow-up ranging from 12 months to more than 10 years. [14][15][16][17] Similarly, among the 41 patients in the present study who reported symptoms due to mass effect of the large kidneys, w70% experienced improvement in their symptoms. Adverse events occurred, comprising postprocedure pain in 9 patients (lasting for >1 month in 2), 1 potential and 2 definite procedurerelated cyst infections, and asymptomatic intermittent hematuria for several days in 1 patient.…”

supporting

confidence: 63%

“…All older studies, as well as the the present cohort study, were observational and underpowered to determine long-term effects on kidney function, but the general conclusion was that mechanical cyst reduction had no detrimental but also no beneficial effect on progression to ESKD. [14][15][16][17] Why does reduction of total kidney volume by cyst aspiration not lead to improvement in kidney function in this and the older studies? One obvious reason is that only a few cysts among hundreds to thousands can be targeted by foam sclerotherapy.…”

mentioning

confidence: 89%

mentioning

confidence: 99%

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Quest for the Cure: Testing the Old and New to Prevent Progression of Autosomal Dominant Polycystic Kidney Disease

Brosnahan

2019

Kidney Medicine

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confidence: 63%

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confidence: 89%

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Quest for the Cure: Testing the Old and New to Prevent Progression of Autosomal Dominant Polycystic Kidney Disease

Brosnahan

2019

Kidney Medicine

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“…Current management strategies include blood pressure control (commonly achieved by administering medications that interact with the renin-angiotensin-aldosterone pathway) and minimization of nephrotoxin exposure (18). Symptomatic dominant cysts have been treated successfully with image-guided aspiration and ethanol sclerotherapy (also known as ethanol sclerosis), with excellent long-term outcomes (19).…”

Section: Hereditary Renal Cystic Disorders and Their Key Featuresmentioning

confidence: 99%

Hereditary Renal Cystic Disorders: Imaging of the Kidneys and Beyond

et al. 2017

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The purpose of this article is to review the hereditary renal cystic diseases that can manifest in children and adults, with specific attention to pathogenesis and imaging features. Various common and uncommon hereditary renal cystic diseases are reviewed in terms of their underlying etiology, including the involved genetic mutations and the affected proteins and cellular structures. Focus is placed on the morphologic findings in each condition and the features that distinguish one disorder from another. The two most common categories of hereditary renal cystic disease are (a) the ciliopathic disorders, which are related to mutations affecting the primary cilia (called "ciliopathies"), and (b) the phakomatoses. Autosomal dominant polycystic kidney disease, autosomal recessive polycystic kidney disease, and the "medullary cystic disease complex" are all ciliopathies but have different phenotypes. Tuberous sclerosis complex and the associated "contiguous gene syndrome," as well as von Hippel-Lindau syndrome, are phakomatoses that can manifest with cystic renal lesions but have uniquely different extrarenal manifestations. Finally, DICER1 mutations can manifest with renal cystic lesions (typically, cystic nephromas) in patients predisposed to other malignancies in the chest, ovaries, and thyroid. Although some overlap exists in the appearance of the renal cysts associated with each of these diseases, there are clear morphologic differences (eg, cyst size, location, and complexity) that are emphasized in this review. To improve patient outcomes, it is important for the radiologist to recognize the various hereditary renal cystic diseases so that a correct diagnosis is assigned and so that the patient is adequately evaluated and followed up. RSNA, 2017.

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“…A variety of therapeutic interventions have been described for benign symptomatic cystic lesions of the kidney. These include cyst aspiration 5 , surgical resection 6 , 7 , and sclerotherapy with a variety of different agents 8 , 9 . Although none of these approaches appear to be better than the others described, aspiration and sclerotherapy are associated with a higher incidence of cyst recurrence, fever, and ureteropelvic junction obstruction regarding the treatment of peripelvic cysts, given their proximity to the renal vessels and collecting system.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous ureteroscopy laser unroofing-a minimally invasive approach for renal cyst treatment

Dirie

Yang

et al. 2017

Sci Rep

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Most simple renal cysts rarely require therapy. When it grows to such a large size, regardless of the presence of symptomatology, surgical intervention is required. In this study, we explored a new approach called percutaneous ureteroscopy laser unroofing for treatment renal cysts and evaluated its safety and efficacy. 71 simple renal cyst patients with surgical indications were enrolled, including 6 patients with a peripelvic cyst and 5 patients coexisting ipsilateral calculi. Under ultrasound guidance, an eighteen-gauge needle was placed inside the cyst cavity, and a guidewire was introduced followed by sequential dilation up to 28 F. The extra-parenchymal portion of cyst wall was dissociated and incised using either a Thulium or Holmium laser, and a pathological examination was performed. Renal calculi were treated simultaneously. For peripelvic cyst patients, one end of a double-J stent was inserted into the cyst cavity to prevent auto-closure. Mean of 11.7 months follow-up, the results showed that the cyst was completely resolved in 53 patients, its size was reduced to less than 50% in 15 patients, and treatment failed in only 3 anterior cyst patients, suggesting that percutaneous ureteroscopy laser unroofing is an effective and less invasive alternative for treatment of renal cysts in selected patients.

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Long-term functional results of aspiration and sclerotherapy with ethanol in patients with autosomal dominant polycystic kidney disease: a non-randomized pilot clinical study

Abstract: Aspiration and sclerotherapy with ethanol is a minimal-invasive, safe, and inexpensive outpatient treatment method with acceptable short- and long-term results in ADPKD patients. Aspiration and sclerotherapy with ethanol can be an option for patients with ADPKD.

Cited by 5 publications

References 21 publications

Quest for the Cure: Testing the Old and New to Prevent Progression of Autosomal Dominant Polycystic Kidney Disease

Quest for the Cure: Testing the Old and New to Prevent Progression of Autosomal Dominant Polycystic Kidney Disease

Hereditary Renal Cystic Disorders: Imaging of the Kidneys and Beyond

Percutaneous ureteroscopy laser unroofing-a minimally invasive approach for renal cyst treatment

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