Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study

Kurosawa, Saiko; Kim, Sung-Won; Fuji, Shigeo; Yamashita, Takuya; Tanosaki, Ryuji; Fukuda, Takahiro; Mori, Akira; Tsukagoshi, Mayumi; Yamaguchi, Takuhiro

doi:10.7889/hct.3.49

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…In accordance with our study (71% at 2 years), other studies reported an 81%–89% of social reintegration at 5 year post-transplant 27 , 28 . In this study, we focused on reintegration not at 5 but 2 years post-HSCT, primarily because this is the earliest timing when the risk of infection and cGVHD is saturated 29 , and also because previous studies have indicated that 1–2 years is the median time needed for patients to return to their work 6 , 30 .…”

Section: Discussionmentioning

confidence: 99%

Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration

Hamada

Arai

Kondo

et al. 2021

Sci Rep

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As the proportion of long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is on the rise, it is essential to consider the significance of quality of life (QOL), including reintegration with society (returning to school or work). This retrospective cohort study aims to illustrate the precise epidemiology of social reintegration later after allo-HSCT and determine its predictive indicators. We enrolled 56 patients, and 40 patients (71%) attained social reintegration at 2 years post-HSCT. Reintegration failure markedly correlated with an inferior performance status and concurrent chronic graft-versus-host disease. In non-reintegrated patients, the physical function at discharge measured by the 6-min walking distance (6MWD) was markedly decreased. On the multivariate risk analyses, sex (female; odds ratio (OR) 0.07; 95% confidence interval (CI) 0.01–0.54; p = 0.01), HCT-CI (≥ 2; OR 0.10; 95% CI 0.01–0.84; p = 0.03), and change in 6MWD (per 5% increase; OR 1.47; 95% CI 1.01–2.13; p = 0.04) were significant predictors of later social reintegration. This study suggests that a multidisciplinary strategy including rehabilitation is essential, especially in patients with poor predictive markers at an early phase, and we should consider suitable rehabilitation programs to prevent a decline in exercise tolerance and improve social reintegration and overall QOL in patients after allo-HSCT.

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Section: Discussionmentioning

confidence: 99%

Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration

Hamada

Arai

Kondo

et al. 2021

Sci Rep

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“…GVHD responded promptly, and prednisolone was discontinued by of changes in employment status significantly related to the degree of cGVHD. 2,3 It is reported that the mental recovery of women without social support is relatively slow. 4 When one thinks about the factors that impair QOL, the major problems after HCT are related to the many symptoms of cGVHD, resulting in an inability to return to work.…”

Section: Case Reportmentioning

confidence: 99%

“…More than 90% of the general population has been infected with HHV6, mostly during early childhood. 2 After primary infection, HHV6 remains latent in the host.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing health-related quality of life for patients after hematopoietic stem cell transplantation: a single institution analysis

Hamada

Hasegawa

Okamoto

et al. 2017

Journal of Hematopoietic Cell Transplantation

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IntroductionMore than 5,000 patients receive hematopoietic stem cell transplantations(HCT)annually in Japan, and the number of allogeneic HCT(allo-HCT)has increased in particular.Originally, HCT was only used for young patients who did not to respond to chemotherapy, but now additional types of disease and a broader age range are suitable for transplants because of improved medications and methods for HCT. As the number of long-term survivors is increasing rapidly, improvement in the health-related quality of life(QOL)after HCT is necessary. Non-myeloablative transplants were successful after 2000, and HCT was performed on patients aged 50 years or older. In the last five years, 40% of allo-HCT patients are 50 or older. Compared with ten years ago, the numbers of HCTs for both leukemia and malignant lymphoma among patients aged 50 years or older have risen by 123% and 62%, respectively.1 Thus, progress in HCT treatment has resulted in a diversified social background of HCT patients, which suggests that the optimal methods for long-term careand improvement of QOL have also changed. Previously, many QOL studies on HCT patients were performed using the Medical Outcomes Study Short Form-36Health Survey(SF-36) . Previous studies reported that all of the average SF-36 subscales were below Japanese standards.Moderate to severe chronic graft-versus-host disease (cGVHD)as defined by the National Institutes of Health

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Feasibility and usefulness of recommended screenings at long-term follow-up clinics for hematopoietic cell transplant survivors

Kurosawa¹,

Yamaguchi

Mori

et al. 2021

Support Care Cancer

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Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study

Cited by 4 publications

References 19 publications

Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration

Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration

Factors influencing health-related quality of life for patients after hematopoietic stem cell transplantation: a single institution analysis

Feasibility and usefulness of recommended screenings at long-term follow-up clinics for hematopoietic cell transplant survivors

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