Long-term follow-up study of artificial dermis composed of outer silicone layerand inner collagen sponge

Suzuki, Shigehiko; Kawai, Katsuya; Ashoori, Faramartz; Morimoto, Naoki; Nishimura, Yoshihiko; Ikada, Yoshito

doi:10.1054/bjps.2000.3426

Cited by 127 publications

(69 citation statements)

References 19 publications

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“…It can be used in acute burn treatment and reconstruction procedures, as a single layer in trauma cases, or on other skin loss areas after surgery for tumor or nevus removal. It is very effective in functional and cosmetic improvements [7][8][9][10] and postprocedure contracture defects are found to be insignificant [11]. For the present patient, the cosmetic and functional appearance on his left arm was improved.…”

Section: Discussionmentioning

confidence: 52%

The use of artificial dermis for corrective surgery on burn scars

Praditsuktavorn

Muangman

2015

Asian Biomedicine

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Background: Hypertrophic scarring from burn injuries on large skin areas is of great concern for both patients and attending physicians because of significant functional and cosmetic impairment. Surgery for scar corrections is challenging because of limitations on the availability of normal tissue. An alternative method for scar correction using artificial dermis is now possible. Artificial dermis can be used in the reconstruction of scars, burn injuries on large skin areas and in patients who do not have sufficient donor sites for skin grafts after scar excisions. Objective: To report the efficacy of artificial dermis on a 20 years old Thai man with severe scar contracture from burn injuries.Method: An open-label case study, the severe contracture case underwent scar excision and was applied with artificial dermis. Result: A 20-year-old man had severe scar contractures on his left arm, forearm, and elbow, and a shearing wound with a scar at his left elbow. Total scar excision was done on his left arm, forearm, elbow, and hand, and then followed by application of artificial dermis on to the wounds. After 2 weeks, neodermis formation was observed, after which an ultrathin split thickness skin graft was applied to the wounds. One month after sugery, the patient could extend his left elbow fully and the cosmetic result is satisfactory. Conclusion: Use of artificial dermis should be a new alternative modality in improving our strategy in correcting scar issues from burn injuries, especially on large burn scar areas with limited donor sites for skin grafts.

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Section: Discussionmentioning

confidence: 52%

The use of artificial dermis for corrective surgery on burn scars

Praditsuktavorn

Muangman

2015

Asian Biomedicine

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“…Artificial dermis has emerged as a medical material for healing deep skin defects, where it is gradually replaced by dermal-like granulation tissue, and has been used mainly in plastic surgery to date. 10) We here describe the use of artificial dermis in decompressive skinplasty for the control of intracranial pressure to manage severe brain swelling. We applied Pelnac } onto the artificial dura in the first two cases and onto the temporal muscle in the latter 3 cases.…”

Section: Discussionmentioning

confidence: 99%

New Technique of Decompressive Skinplasty With Artificial Dermis for Severe Brain Swelling

Akutsu¹,

Aihara²,

Sakurai³

et al. 2013

Neurol. Med. Chir.(Tokyo)

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In cases of severe uncontrollable brain swelling, simple skin closure often increases intracranial pressure. This study examined the efficacy of a new technique of decompressive skinplasty to decrease intracranial pressure following decompressive craniectomy in cases of severe traumatic brain injury with uncontrollable brain swelling. In our technique, we use artificial dermis to avoid elevation of intracranial pressure. After performing decompressive craniectomy and duraplasty with artificial dura, decompressive skinplasty with artificial dermis was performed in 5 patients for whom simple skin closure caused the intracranial pressure to elevate under intracranial pressure monitoring. Artificial dermis was grafted onto the region to cover the skin defect and sutured to the skin with 4-0 nylon sutures. Two weeks after surgery, the silicone layer of the artificial dermis was removed and ointment treatment was continued until complete epithelialization was achieved. In all cases, decompressive skinplasty contributed dramatically to decreasing the intracranial pressure in patients with uncontrollable brain swelling. The technique of decompressive skinplasty with artificial dermis contributed to dramatically decreasing the intracranial pressure. More cases are required to investigate the indications for this technique.

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“…The grafting of allogeneic dried dura mater as a medical material had significant relation to the onset of the fatal encephalopathy, CJD (5), suggesting that the infection of abnormal prion protein from the biomaterial to human subjects had occurred (32). Because the commercial artificial dermises frequently used in the field of dermatology and the plastic reconstructive surgery are made of the collagen extracted from mammals (21,35), it cannot be completely denied that abnormal prion proteins and/or an unknown pathogen contaminate these materials. The utilization of a chemical compound like poly(-l-lactic acid) as a medical material does not cause infectious diseases, but the biological affinity of chemical compounds is generally lower than that of materials derived from creatures and a chemical compound often causes inflammation at the contact site when it is transplanted into or onto a creature (6).…”

Section: Discussionmentioning

confidence: 99%

The usefulness of the collagen and elastin sponge derived from salmon as an artificial dermis and scaffold for tissue engineerin

Matsumoto

Ikeda

Yamaya³

et al. 2011

Biomed. Res.

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Collagen sponge is one of the medical materials that are frequently used in clinical medicine. However, the problem of prion disease harmfully affected the usage of mammals-derived medical materials. Since there have been no reports about prion disease occurring in marine products, we produced the collagen and elastin sponge (CES) made from salmon, and investigated whether the CES could be a substitute for mammalian collagen sponge. Fibroblasts were seeded in the CES to examine whether the CES could be used as a scaffold for tissue engineering. The results of the WST-1 assay showed that the fibroblasts were viable and were well proliferated in the CES. To examine whether the CES could be used as an artificial dermis, the CES and TERUDERMIS (traditional collagen sponge) were grafted onto the skin defects on the dorsum of rats. The histological findings of these ulcers showed non-significant difference between the CES and TERUDERMIS. Because of the safety, the abundance of the resources, and the possessing same ability as TERUDERMIS, the biomedical materials derived from marine products may be a substitute for those derived from mammals.Collagen sponge is one of the biomedical materials frequently used in clinical medicine, especially in dermatology and plastic reconstructive surgery. It has been used as a biomaterial which covers fullthickness skin defects for the treatments of diseases and conditions such as burn (13,30,42), trauma (16), chronic skin ulcer (2, 10), excised skin tumor (23,33,38) and others that cause full-thickness skin defects. The main ability of collagen sponge is to accelerate tissue granulation (7), as forming good granulation from a relatively early stage-even on a tendon (18, 37) and bone (16,23,38,42), which generally takes a long time to form. And this ability is able to make a wound heal fast by using secondary skin grafting. The combined treatment with collagen sponge and skin grafting is less invasive for patients than other operative methods covering skin defects, such as local skin flaps, pedicled flaps, and free flaps because it is technically easy and takes a short time to perform the combination treatment (23,38). Collagen sponge is a very important treatment tool in dermatology and plastic reconstructive surgery. Collagen sponge is expected to be used as a scaffold for tissue engineering because of its high ability of cell adherence and biological affinity. It has contributed to regenerating various tissues such as

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Long-term follow-up study of artificial dermis composed of outer silicone layerand inner collagen sponge

Cited by 127 publications

References 19 publications

The use of artificial dermis for corrective surgery on burn scars

The use of artificial dermis for corrective surgery on burn scars

New Technique of Decompressive Skinplasty With Artificial Dermis for Severe Brain Swelling

The usefulness of the collagen and elastin sponge derived from salmon as an artificial dermis and scaffold for tissue engineerin

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