Long-term follow-up of unresectable medium-large hepatocellular carcinoma nodules treated with radiofrequency ablation using a multiple-electrode switching system

Francica, Giampiero; Altiero, Michele; Laccetti, Ettore; Pezzullo, Filomena; Tanga, Michela; Avitabile, Giuseppe; Elameer, Mathew; Scaglione, Mariano

doi:10.1259/bjr.20180625

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…In the follow-up, the OS at 4 years was 49%. 69 Another series included HCC with a median size of 9 cm treated by stereotactic RFA and reported efficacy of ablation of 80.5% with treatment-related mortality of 2.3%. Major complication rate here was 20.5%.…”

Section: Increasing the Size Of Ablated Lesionsmentioning

confidence: 99%

“…Mbp‐RFA treatment in HCC nodules with sizes between 3 and 6 cm in nonsurgical candidates with liver cirrhosis reported the complete ablation in all nodules without procedure‐related death or major complications. In the follow‐up, the OS at 4 years was 49% 69 . Another series included HCC with a median size of 9 cm treated by stereotactic RFA and reported efficacy of ablation of 80.5% with treatment‐related mortality of 2.3%.…”

Section: Introductionmentioning

confidence: 99%

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Percutaneous treatments of hepatocellular carcinoma: Improving efficacy, applicability and extending ablation criteria

Gigante

Nahon

Séror

et al. 2022

Liver Cancer International

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Hepatocellular carcinoma (HCC) is considered to be the sixth most common cancer worldwide and the fourth deadliest cancer accounting for 782 000 deaths/y. In 2018, the incidence rate of liver cancer was 9.3 per 100 000 person-years with a similar death rate. 1,2 However, several advances occurred in the management of patients with HCC including screening programs and the development of curative and palliative treatments. 3 The treatments considered as curative are liver resection, liver transplantation and percutaneous ablation with a 5-year survival rate ranging from 60% to 80%. 4 The most frequent techniques used in percutaneous treatments are radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation (CA) and irreversible electroporation (IRE). 5,6 The first enlisted

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Section: Increasing the Size Of Ablated Lesionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Percutaneous treatments of hepatocellular carcinoma: Improving efficacy, applicability and extending ablation criteria

Gigante

Nahon

Séror

et al. 2022

Liver Cancer International

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“…6,14,15 The ablation effect was mainly enhanced by double or multiple antennas/electrodes placed simultaneously, thermal ablation combined with transarterial chemoembolization (TACE), or utilizing 3D visualization preoperative planning system to assist ablation. 6,[17][18][19] The literature reported that thermal ablation combined with TACE was superior to thermal ablation alone for liver cancer with a diameter of 3-7 cm that could not be surgically resected. [20][21][22][23] Nevertheless, these strategies increased medical expenses inevitably, and the trauma or side effects of TACE could not be ignored.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Microwave Ablation Assisted by Ultrasound Fusion Imaging for Primary and Secondary Liver Cancers with a Diameter of 3–7 Cm

Yang,

Liang,

Liu

et al. 2023

JHC

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Purpose To investigate the efficacy and safety of microwave ablation (MWA) assisted by ultrasound fusion imaging (FI) for primary and secondary liver cancers with a diameter of 3–7 cm. Patients and Methods A retrospective analysis was conducted on patients with primary and secondary liver cancers (3–7 cm) who underwent MWA with ultrasound FI assistance in our hospital from April 2020 to May 2022. Technical success, technique efficacy, local tumor progression (LTP), major complication, intrahepatic distant recurrence (IDR), and overall survival (OS) were assessed during the follow-up period. In addition, the ablation results of tumors between the medium-sized group (3.1–5.0 cm) and large-sized group (5.1–7.0 cm) were compared. Results 31 patients with 35 primary and secondary liver cancers were treated with MWA assisted by ultrasound FI. Complete ablation was achieved in 34 lesions with a technical success rate of 97.1%. Major complications occurred in 6.5% of patients (2/31), while no ablation-related deaths were reported. The median follow-up time of this study was 24 months (range:10 to 35 months). The technique efficacy rate was 97.1% (34/35), with LTP occurring in three lesions at a rate of 8.8% (3/34). The incidence of IDR was 38.7% (12/31) and the 2-year cumulative OS rate reached 96.7%. Moreover, there were no statistical differences in technique efficacy rate (p=0.286), LTP rate (p=0.328), major complication rate (p=0.503), IDR (p=0.857), and OS (p=0.118) between medium-sized group and large-sized group. Conclusion Ultrasound FI-assisted MWA has the potential to be an effective and safe therapeutic strategy for primary and secondary liver cancers ranging from 3–7 cm in size.

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“…Efforts have been made to enlarge the thermal field for RFA, to break the 3 cm tumor barrier in thermal ablation. Although multiple electrode placement [7][8][9] and RFA plus transcatheter arterial chemoembolization (TACE) 10,11 have been applied, local tumor progression (LTP) remains a challenge for large HCC. No-touch multibipolar RFA, a new technique of RFA for complete tumor necrosis, provides higher intensity energy than traditional RFA, although it remains associated with greater recurrence rates than those observed with SR in tumors larger than 3 cm 3,12 .…”

Section: Introductionmentioning

confidence: 99%

Microwave ablation vs. surgical resection for treatment naïve hepatocellular carcinoma within the Milan criteria: a follow-up of at least 5 years

et al. 2021

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Objective: Thermal ablation poses challenges in the surgical resection (SR) of small hepatocellular carcinoma (HCC), and its therapeutic outcomes for larger lesions remain debated. Methods: This retrospective study evaluated 729 patients with HCC meeting the Milan criteria, who were treated with curative SR or microwave ablation (MWA) between 2008 and 2014. Overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and local tumor progression (LTP) were compared after propensity score matching (PSM). Co-variates associated with OS, CSS, LTP, and DFS were identified. The risk of death and tumor progression were compared. Results: During the median follow-up of 78.6 months, 253 patients were included in each group after PSM. For tumors ≤ 3.0 cm and 3.1-4.0 cm, MWA achieved comparable results in terms of OS, CSS, DFS, and LTP. For tumors 4.1-5.0 cm, MWA had lower OS, CSS, and DFS rates (all P < 0.05) than SR. Higher LTP rates were observed in the MWA group for tumors 4.1-5.0 cm, although the difference was not significant (P = 0.18). Complication rates (P = 0.41) were similar, but MWA led to less estimated blood loss (P < 0.01) and shorter postoperative hospitalization times (P < 0.01). Conclusions: MWA achieved comparable long-term oncologic outcomes with SR for ≤ 4 cm HCC, with lower complication rates and faster recovery.

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Long-term follow-up of unresectable medium-large hepatocellular carcinoma nodules treated with radiofrequency ablation using a multiple-electrode switching system

Abstract: Avitabile G, et al. Long-term follow-up of unresectable medium-large hepatocellular carcinoma nodules treated with radiofrequency ablation using a multiple-electrode switching system.

Cited by 8 publications

References 30 publications

Percutaneous treatments of hepatocellular carcinoma: Improving efficacy, applicability and extending ablation criteria

Percutaneous treatments of hepatocellular carcinoma: Improving efficacy, applicability and extending ablation criteria

Efficacy and Safety of Microwave Ablation Assisted by Ultrasound Fusion Imaging for Primary and Secondary Liver Cancers with a Diameter of 3–7 Cm

Microwave ablation vs. surgical resection for treatment naïve hepatocellular carcinoma within the Milan criteria: a follow-up of at least 5 years

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